o-(6)-methylguanine has been researched along with Cancer of Lung in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (19.35) | 18.7374 |
| 1990's | 8 (25.81) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 8 (25.81) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Hiddinga, B; Janssens, A; Pauwels, P; Van Meerbeeck, J; Zwaenepoel, K | 1 |
| Chari, R; Chung, HJ; Evans, CN; Fetsch, P; Filie, A; Hassan, R; Jiang, Q; Khanal, M; Morrow, B; Murai, J; Pommier, Y; Raffeld, M; Rathkey, D; Roth, M; Sengupta, M; Thomas, A; Xi, L; Zhang, J | 1 |
| Gao, Y; Peng, RW; Schmid, RA; Xu, D; Yang, H | 1 |
| Hassan, R; Murai, J; Pommier, Y; Sengupta, M | 1 |
| Hecht, SS; Leitzman, P; Narayanapillai, SC; O'Sullivan, MG; Puppala, M; Sun, H; Upadhyaya, P; Xing, C | 1 |
| Ding, X; Liu, Z; Megaraj, V; Xie, F; Yang, W; Zhou, X | 1 |
| Chao, MR; Chen, JL; Hu, CW; Lee, H; Li, YJ | 1 |
| Balbo, S; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Balbo, S; Grill, AE; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Peterson, LA; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Amin, SG; Belinsky, SA; Collins, LB; Crowell, RE; Desai, D; Gilliland, FD; Jauregui, AR; Juri, DE; Leng, S; Lin, Y; Liu, Y; Picchi, MA; Stidley, CA; Swenberg, JA; Tellez, CS; Thomas, CL; Wathelet, MG; Wu, G; Zhang, X | 1 |
| Hecht, SS; Lindgren, BR; Upadhyaya, P | 1 |
| Chen, Y; Hou, YY; Hu, Q; Ji, CH; Shi, Y; Su, JA; Tan, YS; Zhou, Y | 1 |
| Kassie, F; Modiano, JF; Murphy, SE; Schutten, MM; von Weymarn, LB | 1 |
| Hecht, SS; Jalas, JR; Kenney, PM; McIntee, EJ; Peterson, LA; Upadhyaya, P | 1 |
| Behr, M; Ding, X; Fang, C; Kaminsky, LS; Turesky, RJ; Weng, Y | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Foley, JF; Greenwell, A; Hegi, ME; Maronpot, RR; Patel, AC; White, CM | 1 |
| Morse, MA; Stoner, GD | 1 |
| Horikawa, S; Ichikawa, T; Kishimoto, M; Nakamura, T; Yajima, S; Yano, T | 1 |
| Ichikawa, T; Kishimoto, M; Kumagai, H; Otani, S; Sakurai, H; Virgona, N; Yajima, S; Yano, T; Yano, Y | 1 |
| Crankshaw, DL; Donaldson, EE; Kenney, PJ; Peterson, LA; Thomson, NM | 1 |
| Amin, SG; Chung, FL; Han, C; Ho, CT; Xu, Y | 1 |
| Hecht, SS; Peterson, LA | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR | 1 |
| Anderson, MW; Belinsky, SA; Foley, JF; Maronpot, RR; White, CM | 1 |
| Choi, CI; Hecht, SS; Jordan, KG; Trushin, N | 1 |
| Doerjer, G; Krause, T; Lehnert, G; Nowak, D; Rüdiger, HW; Schwartz, U; Serrand, E; Stief, M | 1 |
| Amin, SG; Chung, FL; Hecht, SS; Morse, MA | 1 |
| Tisdale, MJ | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Swenberg, JA; White, CM | 1 |
| Carmella, SG; Chung, FL; Hecht, SS; Wang, M | 1 |
| Castonguay, A; Hecht, SS; Rivenson, A; Trushin, N | 1 |
31 other study(ies) available for o-(6)-methylguanine and Cancer of Lung
| Article | Year |
|---|---|
Are anaplastic lymphoma kinase (ALK) and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation driver biomarkers of pulmonary neuroendocrine tumors (NETs) and carcinomas (NECs)?
Topics: Anaplastic Lymphoma Kinase; Biomarkers; Carcinoid Tumor; Carcinoma, Neuroendocrine; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Guanine; Humans; Lung Neoplasms; Neuroendocrine Tumors; O(6)-Methylguanine-DNA Methyltransferase; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2022 |
Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.
Topics: Cell Line, Tumor; Guanine; Humans; Lung Neoplasms; Mesothelioma; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2020 |
The Association of BAP1 Loss-of-Function With the Defect in Homologous Recombination Repair and Sensitivity to PARP-Targeted Therapy.
Topics: DNA; DNA Repair; Guanine; Humans; Lung Neoplasms; Mesothelioma; Methyltransferases; Poly(ADP-ribose) Polymerase Inhibitors; Recombinational DNA Repair; Temozolomide; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2020 |
Response to Letter to the Editor by Yang et al.
Topics: DNA; Guanine; Humans; Lung Neoplasms; Mesothelioma; Methyltransferases; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2020 |
Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Female; Guanine; Lung; Lung Neoplasms; Mice; Nitrosamines; Pyrones; Structure-Activity Relationship | 2017 |
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; DNA Adducts; Guanine; Humans; Lung Neoplasms; Mice, Transgenic; Microsomes; Nicotiana; Nitrosamines; Pyridines | 2014 |
Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients.
Topics: Adenine; Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Chromatography, Liquid; Deoxycytidine; DNA Methylation; DNA, Neoplasm; Female; Fungal Proteins; Guanine; Humans; Indicator Dilution Techniques; Limit of Detection; Lung Neoplasms; Male; Middle Aged; Reproducibility of Results; Single-Strand Specific DNA and RNA Endonucleases; Solid Phase Extraction; Tandem Mass Spectrometry; Tumor Microenvironment | 2013 |
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.
Topics: Adenoma; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; Female; Guanine; Kava; Lung; Lung Neoplasms; Mice; Nitrosamines | 2014 |
Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.
Topics: Animals; Carcinogens; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Female; Guanine; Kava; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Pyrones; Structure-Activity Relationship | 2014 |
Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.
Topics: Base Sequence; Chromosomes, Human, Pair 15; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epithelial Cells; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Guanine; Humans; Longitudinal Studies; Lung Neoplasms; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Polymorphism, Single Nucleotide; Smoking; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2015 |
Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Guanine; Liver; Lung; Lung Neoplasms; Nicotiana; Nitrosamines; Prohibitins; Rats; Rats, Inbred F344 | 2009 |
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; DNA-Activated Protein Kinase; Guanine; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Immunohistochemistry; Immunoprecipitation; Lung; Lung Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Adenoma; Animals; Carcinogens; Cells, Cultured; Drinking Water; Female; Guanine; Humans; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nicotine; Nitrosamines | 2011 |
Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Deuterium; DNA; DNA Adducts; Dose-Response Relationship, Drug; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes; Mixed Function Oxygenases; Molecular Structure; Nitrosamines; Stereoisomerism; Structure-Activity Relationship | 2003 |
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Topics: Animals; Carcinogens; Doxycycline; Female; Guanine; Inbreeding; Liver; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Transgenic; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Pyridines | 2007 |
Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains.
Topics: Animals; Base Sequence; DNA; Gene Expression; Genes, p53; Genes, ras; Guanine; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Polymerase Chain Reaction | 1993 |
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; DNA Methylation; Dose-Response Relationship, Drug; Ellagic Acid; Esophageal Neoplasms; Female; Guanine; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA injury and the fixation of the DNA injury in mouse lungs.
Topics: Animals; Carcinogens; DNA Damage; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Rabbits; Specific Pathogen-Free Organisms; Vitamin E | 1998 |
The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica (wasabi) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-buatnone-induced lung tumorigenesis in mice.
Topics: Animals; Body Weight; Carcinogens; Female; Guanine; Immunoblotting; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Ornithine Decarboxylase; Plant Extracts; Proliferating Cell Nuclear Antigen; Spices | 2000 |
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2001 |
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Caffeine; Carcinogens; Catechin; Deoxyguanosine; DNA; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Tea | 1992 |
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Female; Guanine; Hydroxylation; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1991 |
Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.
Topics: Animals; Base Sequence; Codon; Dimethylnitrosamine; DNA; Drug Resistance; Gene Expression Regulation, Neoplastic; Genes, ras; Guanine; Incidence; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Molecular Sequence Data; Mutation; Nitrosamines; Proto-Oncogenes; Thymine; Time Factors | 1991 |
Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cell Line; DNA; Dose-Response Relationship, Drug; Guanine; Hyperplasia; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Metaplasia; Methylation; Microscopy, Electron; Nitrosamines; Nose Neoplasms; Olfactory Mucosa; Rats; Rats, Inbred F344 | 1990 |
Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice.
Topics: Adenoma; Animals; Carcinogens; Deuterium; DNA; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Structure-Activity Relationship | 1990 |
Reduced O6-methylguanine repair in fibroblast cultures from patients with lung cancer.
Topics: Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; DNA Repair; Female; Fibroblasts; Guanine; Humans; Lung Neoplasms; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase | 1989 |
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Topics: Adenoma; Animals; Cricetinae; Cyanates; Female; Guanine; Isocyanates; Isothiocyanates; Lung; Lung Neoplasms; Mice; Microsomes; Nitrosamines; Thiocyanates | 1989 |
Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Chlorambucil; Colonic Neoplasms; Dacarbazine; DNA Repair; Dose-Response Relationship, Drug; Guanine; Humans; Imidazoles; Kinetics; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Methyltransferases; Mice; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide | 1987 |
Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Alkylation; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Lung; Lung Neoplasms; Methyltransferases; Nicotiana; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Plants, Toxic; Rats; Rats, Inbred F344 | 1987 |
Effects of butylated hydroxyanisole on the tumorigenicity and metabolism of N-nitrosodimethylamine and N-nitrosopyrrolidine in A/J mice.
Topics: Animals; Anisoles; Biotransformation; Butylated Hydroxyanisole; Dimethylnitrosamine; Female; Glutathione; Glutathione Transferase; Guanine; Lung; Lung Neoplasms; Mice; Microsomes; Microsomes, Liver; N-Nitrosopyrrolidine; Nitrosamines | 1986 |
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA, Neoplasm; Guanine; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats | 1986 |