Page last updated: 2024-08-24

o-(6)-methylguanine and Astrocytoma, Grade IV

o-(6)-methylguanine has been researched along with Astrocytoma, Grade IV in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (4.76)	18.2507
2000's	1 (4.76)	29.6817
2010's	11 (52.38)	24.3611
2020's	8 (38.10)	2.80

Authors

Authors	Studies
Chamallamudi, MR; Kumar, G; Kumar, N; Nandakumar, K; Rao, V; Thorat, ND; Vibhavari, RJA	1
Cao, D; Huang, W; Su, Y; Xing, Z; Yang, X; Zhou, X	1
Baek, JY; Beom, SH; Cha, Y; Choi, J; Choi, MK; Hong, YS; Kim, J; Kim, JE; Kim, JH; Kim, SY; Kim, TW; Lee, JS; Lim, SB; Oh, CR; Park, IJ; Park, JH	1
Gupta, N; Jena, B; Kalra, M; Mohapatra, B; Saba, L; Saxena, S; Scartozzi, M; Suri, JS	1
Fang, X; Feng, M; Jiang, CM; Jiang, LY; Li, XL; Lin, XY; Wang, GH; Xu, JJ; Zhang, HX	1
de Groot, JF; Gao, F; Koul, D; Li, X; Wu, S; Yung, WKA	1
Christensen, K; Clemmensen, S; Hjelmborg, J; Li, S; Li, W; Lund, J; Mengel-From, J; Mohammadnejad, A; Soerensen, M; Tan, Q; Timofeeva, M; Wang, L	1
Boldorini, R; Carriero, A; Cavalieri, S; Cossandi, C; Krengli, M; Masini, L; Stecco, A	1
Cosgrove, L; Fay, MF; Head, RJ; Martin, JH; Rundle-Thiele, D; Y C Fung, K	1
Chumakova, A; Lathia, JD	1
Ahluwalia, MS; Angelov, L; Barnett, GH; Bellamkonda, S; Jia, X; Meola, A; Mohammadi, A; Mohapatra, S; Sharma, M; Vogelbaum, M	1
Fung, CF; Ho, AS; Kiang, KM; Lam, KF; Leung, GK; Lui, WM; Pu, JK; Sun, S; Wong, TS; Zhang, XQ	1
Eich, M; Kaina, B; Nikolova, T; Roos, WP	1
Blumenthal, DT; Moore, DF; Padula, GD; Rankin, C; Rushing, EJ; Schulman, SB; Sloan, AE; Spence, AM; Stelzer, KJ; Wade, ML	1
Bui, Y; Cloughesy, TF; Hong, I; Lai, A; Liau, LM; McBride, WH; Menjivar, JC; Nelson, SF; Stream, A; Tso, CL; Tso, JL; Yamada, K; Yang, S; Yong, WH; Zhang, Y	1
Arita, H; Fukushima, S; Ichimura, K; Matsushita, Y; Miyakita, Y; Narita, Y; Ohno, M; Shibui, S; Takami, H; Yonezawa, M; Yoshida, A	1
Cormier, M; LeBlanc, VC; Morin, PJ; St-Coeur, PD; Touaibia, M	1
Jin, YH; Liu, HY; Shu, F; Wang, QJ; Wang, Z; Yang, Y; Zhang, WB	1
Bradshaw, TD; Stevens, MF; Zhang, J	1
Aghi, M; Martuza, RL; Rabkin, S	1
Bigner, DD; Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Pegg, AE; Rich, J; Schold, SC	1

Reviews

2 review(s) available for o-(6)-methylguanine and Astrocytoma, Grade IV

Article	Year
Temozolomide Resistance: A Multifarious Review on Mechanisms Beyond CNS & neurological disorders drug targets, 2023, Volume: 22, Issue:6 Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide	2023
Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma. Cancer biology & therapy, 2017, Dec-02, Volume: 18, Issue:12 Topics: Antineoplastic Agents, Alkylating; Apoptosis; DNA Adducts; DNA Mismatch Repair; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Mutation; Neoplasm Recurrence, Local	2017

Trials

2 trial(s) available for o-(6)-methylguanine and Astrocytoma, Grade IV

Article	Year
Preoperative Chemoradiotherapy With Capecitabine With or Without Temozolomide in Patients With Locally Advanced Rectal Cancer: A Prospective, Randomised Phase II Study Stratified by O Clinical oncology (Royal College of Radiologists (Great Britain)), 2023, Volume: 35, Issue:2 Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Capecitabine; Chemoradiotherapy; Dacarbazine; DNA; DNA Methylation; DNA Repair Enzymes; Glioblastoma; Humans; Prospective Studies; Rectal Neoplasms; Temozolomide	2023
A Phase III study of radiation therapy (RT) and O⁶-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001. International journal of clinical oncology, 2015, Volume: 20, Issue:4 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; DNA Methylation; Female; Glioblastoma; Gliosarcoma; Guanine; Humans; Male; Middle Aged; Radiotherapy; Young Adult	2015

Article

Year

Preoperative Chemoradiotherapy With Capecitabine With or Without Temozolomide in Patients With Locally Advanced Rectal Cancer: A Prospective, Randomised Phase II Study Stratified by O

Clinical oncology (Royal College of Radiologists (Great Britain)), 2023, Volume: 35, Issue:2

Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Capecitabine; Chemoradiotherapy; Dacarbazine; DNA; DNA Methylation; DNA Repair Enzymes; Glioblastoma; Humans; Prospective Studies; Rectal Neoplasms; Temozolomide

2023

A Phase III study of radiation therapy (RT) and O⁶-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001.

International journal of clinical oncology, 2015, Volume: 20, Issue:4

Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Combined Modality Therapy; DNA Methylation; Female; Glioblastoma; Gliosarcoma; Guanine; Humans; Male; Middle Aged; Radiotherapy; Young Adult

2015

Other Studies

17 other study(ies) available for o-(6)-methylguanine and Astrocytoma, Grade IV

Article	Year
Non-invasive prediction of p53 and Ki-67 labelling indices and O-6-methylguanine-DNA methyltransferase promoter methylation status in adult patients with isocitrate dehydrogenase wild-type glioblastomas using diffusion-weighted imaging and dynamic suscept Clinical radiology, 2022, Volume: 77, Issue:8 Topics: Adult; Brain Neoplasms; DNA; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Magnetic Resonance Imaging; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Perfusion; Retrospective Studies; Tumor Suppressor Protein p53	2022
Fused deep learning paradigm for the prediction of o6-methylguanine-DNA methyltransferase genotype in glioblastoma patients: A neuro-oncological investigation. Computers in biology and medicine, 2023, Volume: 153 Topics: Biomarkers; Brain Neoplasms; Deep Learning; DNA; DNA Methylation; DNA Modification Methylases; Glioblastoma; Humans; Magnetic Resonance Imaging; Methyltransferases	2023
CREB-induced LINC00473 promotes chemoresistance to TMZ in glioblastoma by regulating O6-methylguanine-DNA-methyltransferase expression via CEBPα binding. Neuropharmacology, 2024, Feb-01, Volume: 243 Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; DNA; DNA Modification Methylases; Drug Resistance, Neoplasm; Glioblastoma; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide	2024
PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma. Neuro-oncology, 2021, 06-01, Volume: 23, Issue:6 Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Guanine; Humans; Mice; Poly ADP Ribosylation; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Proteins	2021
Genetic and environmental determinants of O Clinical epigenetics, 2021, 02-15, Volume: 13, Issue:1 Topics: Aged; Aging; Antineoplastic Agents, Alkylating; Cohort Studies; CpG Islands; Cross-Sectional Studies; Denmark; DNA; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Environment; Epigenomics; Female; Gene Silencing; Glioblastoma; Guanine; Humans; Longitudinal Studies; Male; Methyltransferases; Middle Aged; Tumor Suppressor Proteins; Twins, Dizygotic; Twins, Monozygotic	2021
O-6-methylguanine-DNA methyltransferase (MGMT)-methylated pineal glioblastoma in young women. Journal of neurosurgical sciences, 2022, Volume: 66, Issue:1 Topics: Brain Neoplasms; DNA; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Tumor Suppressor Proteins	2022
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Transcriptional control of O Journal of neurochemistry, 2018, Volume: 144, Issue:6 Topics: Antineoplastic Agents, Alkylating; Dacarbazine; DNA; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Temozolomide	2018
Correlation Between the Residual Tumor Volume, Extent of Tumor Resection, and O World neurosurgery, 2018, Volume: 116 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Guanine; Humans; Male; Methyltransferases; Middle Aged; Neoplasm, Residual	2018
A long non-coding RNA signature in glioblastoma multiforme predicts survival. Neurobiology of disease, 2013, Volume: 58 Topics: Age Factors; Brain Neoplasms; DNA Methylation; Female; Gene Expression Profiling; Glioblastoma; Guanine; Humans; Kaplan-Meier Estimate; Male; Microarray Analysis; Predictive Value of Tests; Proportional Hazards Models; RNA, Long Noncoding; Time Factors	2013
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide. Molecular cancer therapeutics, 2013, Volume: 12, Issue:11 Topics: Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Melanoma; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinases; Signal Transduction; Temozolomide; Tumor Suppressor Proteins	2013
Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. Molecular cancer, 2015, Nov-06, Volume: 14 Topics: Antineoplastic Agents, Alkylating; Bone Morphogenetic Protein 7; Cell Proliferation; Cell Survival; Dacarbazine; DNA Modification Methylases; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Neoplastic Stem Cells; Temozolomide; Tumor Cells, Cultured	2015
Glioblastomas with IDH1/2 mutations have a short clinical history and have a favorable clinical outcome. Japanese journal of clinical oncology, 2016, Volume: 46, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Dacarbazine; DNA Methylation; Female; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Japan; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Mutation; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Temozolomide	2016
Effect of O6-Substituted Guanine Analogs on O6-methylguanine DNA-methyltransferase Expression and Glioblastoma Cells Viability. Medicinal chemistry (Shariqah (United Arab Emirates)), 2016, Volume: 13, Issue:1 Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioblastoma; Guanine; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship	2016
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. The Journal of biological chemistry, 2010, Dec-24, Volume: 285, Issue:52 Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mechanistic Target of Rapamycin Complex 1; Methylnitronitrosoguanidine; Multiprotein Complexes; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2010
Temozolomide: mechanisms of action, repair and resistance. Current molecular pharmacology, 2012, Volume: 5, Issue:1 Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Central Nervous System Neoplasms; Dacarbazine; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-(Apurinic or Apyrimidinic Site) Lyase; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide; Tumor Suppressor Proteins	2012
Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication. Journal of the National Cancer Institute, 2006, Jan-04, Volume: 98, Issue:1 Topics: Animals; Antigens, Differentiation; Antineoplastic Agents, Alkylating; Cell Cycle Proteins; Cell Line, Tumor; Comet Assay; Dacarbazine; DNA Damage; DNA Repair; Drug Synergism; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Oncolytic Viruses; Plasmids; Protein Phosphatase 1; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotide Reductases; RNA, Small Interfering; Simplexvirus; Temozolomide; Transcription, Genetic; Transfection; Transplantation, Heterologous	2006
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. Journal of the National Cancer Institute, 1992, Dec-16, Volume: 84, Issue:24 Topics: Animals; Carmustine; Drug Resistance; Female; Glioblastoma; Guanine; Humans; Male; Medulloblastoma; Methyltransferases; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Transplantation, Heterologous	1992