o(6)-benzylguanine has been researched along with Rhabdomyosarcoma in 2 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
Rhabdomyosarcoma: A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous studies exploring melphalan resistance in the human rhabdomyosarcoma xenograft TE-671 MR revealed elevation of DNA polymerase-alpha and DNA polymerase-beta." | 3.69 | Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. ( Ali-Osman, F; Bigner, DD; Elion, GB; Friedman, HS; Keir, S; Marcelli, S; Moynihan, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shankar, S | 1 |
| Zalutsky, MR | 1 |
| Friedman, H | 1 |
| Vaidyanathan, G | 1 |
| Moynihan, K | 1 |
| Elion, GB | 1 |
| Ali-Osman, F | 1 |
| Marcelli, S | 1 |
| Keir, S | 1 |
| Bigner, DD | 1 |
| Friedman, HS | 1 |
2 other studies available for o(6)-benzylguanine and Rhabdomyosarcoma
| Article | Year |
|---|---|
Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.
Topics: Animals; Benzoflavones; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; Guanine; Humans; Iod | 2006 |
Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Aphidicolin; Carmustine; DNA Poly | 1996 |