o(6)-benzylguanine has been researched along with Pancreatic Neoplasms in 4 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human pancreatic cancer L3." | 1.35 | Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis. ( Baker, CH; Bhakat, KK; Bobustuc, GC; Colon, J; Isley, B; Kalkunte, SS; Konduri, SD; Srivenugopal, KS; Sutphin, RM; Ticku, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bobustuc, GC | 2 |
| Patel, A | 1 |
| Thompson, M | 1 |
| Srivenugopal, KS | 2 |
| Frick, J | 1 |
| Weese, J | 1 |
| Konduri, SD | 2 |
| Ticku, J | 1 |
| Sutphin, RM | 1 |
| Colon, J | 1 |
| Isley, B | 1 |
| Bhakat, KK | 1 |
| Kalkunte, SS | 1 |
| Baker, CH | 1 |
| Gupta, S | 1 |
| Sathishkumar, S | 1 |
| Ahmed, MM | 2 |
| Kokkinakis, DM | 1 |
| Chendil, D | 1 |
| Moschel, RC | 1 |
| Pegg, AE | 1 |
4 other studies available for o(6)-benzylguanine and Pancreatic Neoplasms
| Article | Year |
|---|---|
MGMT inhibition suppresses survivin expression in pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; B | 2015 |
Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Proliferation; DNA Modification Methylase | 2009 |
Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Mismatch Repa | 2010 |
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarba | 2003 |