o(6)-benzylguanine has been researched along with Neuroblastoma in 2 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of temozolomide and irinotecan has preclinical schedule-dependent synergy against neuroblastoma but is not curative for relapsed high-risk patients." | 7.74 | Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma. ( Billups, CA; Danks, MK; McLendon, RE; Wagner, LM; Weiss, BD; Yoon, KJ, 2007) |
| "The combination of temozolomide and irinotecan has preclinical schedule-dependent synergy against neuroblastoma but is not curative for relapsed high-risk patients." | 3.74 | Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma. ( Billups, CA; Danks, MK; McLendon, RE; Wagner, LM; Weiss, BD; Yoon, KJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hindle, A | 1 |
| Koneru, B | 1 |
| Makena, MR | 1 |
| Lopez-Barcons, L | 1 |
| Chen, WH | 1 |
| Nguyen, TH | 1 |
| Reynolds, CP | 1 |
| Wagner, LM | 1 |
| McLendon, RE | 1 |
| Yoon, KJ | 1 |
| Weiss, BD | 1 |
| Billups, CA | 1 |
| Danks, MK | 1 |
2 other studies available for o(6)-benzylguanine and Neuroblastoma
| Article | Year |
|---|---|
The O6-methyguanine-DNA methyltransferase inhibitor O6-benzylguanine enhanced activity of temozolomide + irinotecan against models of high-risk neuroblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; DNA Repair; Dose-Respons | 2021 |
Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell | 2007 |