o(6)-benzylguanine has been researched along with Multiple Myeloma in 1 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carmustine (BCNU) is known to have modest activity in multiple myeloma; however, resistance to BCNU manifests by the activity of O6-methylguanine methyltransferase (MGMT)." | 9.12 | O6-benzylguanine and BCNU in multiple myeloma: a phase II trial. ( Bahlis, N; Batts, ED; Fu, P; Gerson, SL; Kane, D; Liu, L; Maisel, C; O'Brien, T; Remick, S, 2007) |
| "Carmustine (BCNU) is known to have modest activity in multiple myeloma; however, resistance to BCNU manifests by the activity of O6-methylguanine methyltransferase (MGMT)." | 5.12 | O6-benzylguanine and BCNU in multiple myeloma: a phase II trial. ( Bahlis, N; Batts, ED; Fu, P; Gerson, SL; Kane, D; Liu, L; Maisel, C; O'Brien, T; Remick, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Batts, ED | 1 |
| Maisel, C | 1 |
| Kane, D | 1 |
| Liu, L | 1 |
| Fu, P | 1 |
| O'Brien, T | 1 |
| Remick, S | 1 |
| Bahlis, N | 1 |
| Gerson, SL | 1 |
1 trial available for o(6)-benzylguanine and Multiple Myeloma
| Article | Year |
|---|---|
O6-benzylguanine and BCNU in multiple myeloma: a phase II trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA; Drug Administration Sc | 2007 |