o(6)-benzylguanine has been researched along with Lung Neoplasms in 6 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In melanoma specimens taken from a patient 3 h post-treatment with temozolomide, MGMT levels were reduced by 70%." | 3.69 | Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase. ( Alas, LG; Belanich, M; Citron, ML; Dolan, ME; Gander, M; Kibitel, JT; Lejeune, FJ; Li, BF; Pastor, MA; Randall, T; Schold, SC; Wasserman, P; White, AB; Yarosh, DB, 1996) |
| "Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules." | 2.69 | O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. ( Gerson, SL; Haaga, J; Hoppel, CL; Ingalls, ST; Liu, L; Majka, S; Pluda, JM; Spiro, TP; Willson, JK, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Urban, AM | 1 |
| Upadhyaya, P | 1 |
| Cao, Q | 1 |
| Peterson, LA | 2 |
| Belanich, M | 1 |
| Randall, T | 1 |
| Pastor, MA | 1 |
| Kibitel, JT | 1 |
| Alas, LG | 1 |
| Dolan, ME | 1 |
| Schold, SC | 1 |
| Gander, M | 1 |
| Lejeune, FJ | 1 |
| Li, BF | 1 |
| White, AB | 1 |
| Wasserman, P | 1 |
| Citron, ML | 1 |
| Yarosh, DB | 1 |
| Egyházi, S | 1 |
| Edgren, MR | 1 |
| Hansson, J | 1 |
| Kröckel, D | 1 |
| Mannervik, B | 1 |
| Ringborg, U | 1 |
| Spiro, TP | 1 |
| Gerson, SL | 1 |
| Liu, L | 1 |
| Majka, S | 1 |
| Haaga, J | 1 |
| Hoppel, CL | 1 |
| Ingalls, ST | 1 |
| Pluda, JM | 1 |
| Willson, JK | 1 |
| Heim, MM | 1 |
| Eberhardt, W | 1 |
| Seeber, S | 1 |
| Müller, MR | 1 |
| Thomson, NM | 1 |
| Crankshaw, DL | 1 |
| Donaldson, EE | 1 |
| Kenney, PJ | 1 |
1 trial available for o(6)-benzylguanine and Lung Neoplasms
| Article | Year |
|---|---|
O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy; Biotransformation; Breast Neoplasms; Carmust | 1999 |
5 other studies available for o(6)-benzylguanine and Lung Neoplasms
| Article | Year |
|---|---|
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.
Topics: Animals; Carcinogens; Deoxyguanosine; DNA Adducts; Enzyme Inhibitors; Female; Guanine; Lung; Lung Ne | 2012 |
Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase.
Topics: Animals; Cell Compartmentation; Cell Nucleus; Cytoplasm; Dacarbazine; DNA Repair; Enzyme Inhibitors; | 1996 |
Role of O6-methylguanine-DNA methyltransferase, glutathione transferase M3-3 and glutathione in resistance to carmustine in a human non-small cell lung cancer cell line.
Topics: Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Carmustine; Dose-Response Relatio | 1997 |
Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines.
Topics: Antineoplastic Agents, Alkylating; DNA Repair; Drug Interactions; Guanine; Humans; Lung Neoplasms; P | 2000 |
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Syne | 2001 |