o(6)-benzylguanine has been researched along with Local Neoplasm Recurrence in 7 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
| Excerpt | Relevance | Reference |
|---|---|---|
| "This phase II trial was designed to define the role of O(6)-benzylguanine (O(6)-BG) in restoring temozolomide sensitivity in patients with recurrent or progressive, temozolomide-resistant malignant glioma and to evaluate the safety of administering O(6)-BG in combination with temozolomide." | 9.14 | Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. ( Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Vredenburgh, JJ; Walker, A, 2009) |
| "This phase I clinical trial conducted with patients who had recurrent or progressive malignant glioma (MG) was designed to determine the maximum tolerated dose (MTD) and toxicity of three different 5-day dosing regimens of temozolomide (TMZ) in combination with O(6)-benzylguanine (O(6)-BG)." | 9.14 | Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma. ( Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Vredenburgh, JJ; Walker, A, 2009) |
| "This phase II trial was designed to define the role of O(6)-benzylguanine (O(6)-BG) in restoring temozolomide sensitivity in patients with recurrent or progressive, temozolomide-resistant malignant glioma and to evaluate the safety of administering O(6)-BG in combination with temozolomide." | 5.14 | Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. ( Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Vredenburgh, JJ; Walker, A, 2009) |
| "This phase I clinical trial conducted with patients who had recurrent or progressive malignant glioma (MG) was designed to determine the maximum tolerated dose (MTD) and toxicity of three different 5-day dosing regimens of temozolomide (TMZ) in combination with O(6)-benzylguanine (O(6)-BG)." | 5.14 | Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma. ( Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Vredenburgh, JJ; Walker, A, 2009) |
| "Twenty-three patients were treated (22 with glioblastoma multiforme and one with anaplastic astrocytoma)." | 2.69 | Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. ( Ashley, DM; Bigner, DD; Cokgor, I; Colvin, OM; Dolan, ME; Ewesuedo, RB; Friedman, AH; Friedman, HS; Garcia-Turner, AM; Haglund, MM; Herndon, JE; Long, L; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Provenzale, JM; Quinn, JA; Rich, JN; Sampson, J; Stewart, ES; Tourt-Uhlig, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Winiczenko, R | 1 |
| Górnicki, K | 1 |
| Kaleta, A | 1 |
| Janaszek-Mańkowska, M | 1 |
| Khan, ZA | 1 |
| Singh, C | 1 |
| Khan, T | 1 |
| Ganguly, M | 1 |
| Bradsher, C | 1 |
| Goodwin, P | 1 |
| Petty, JT | 1 |
| Sandau, C | 1 |
| Bove, DG | 1 |
| Marsaa, K | 1 |
| Bekkelund, CS | 1 |
| Lindholm, MG | 1 |
| Salazar, J | 1 |
| Bermúdez, V | 1 |
| Olivar, LC | 1 |
| Torres, W | 1 |
| Palmar, J | 1 |
| Añez, R | 1 |
| Ordoñez, MG | 1 |
| Rivas, JR | 1 |
| Martínez, MS | 1 |
| Hernández, JD | 1 |
| Graterol, M | 1 |
| Rojas, J | 1 |
| Mubarak, Z | 1 |
| Humaira, A | 1 |
| Gani, BA | 1 |
| Muchlisin, ZA | 1 |
| Gremillet, C | 1 |
| Jakobsson, JG | 1 |
| Gomila, A | 1 |
| Shaw, E | 1 |
| Carratalà, J | 1 |
| Leibovici, L | 1 |
| Tebé, C | 1 |
| Wiegand, I | 1 |
| Vallejo-Torres, L | 1 |
| Vigo, JM | 1 |
| Morris, S | 1 |
| Stoddart, M | 1 |
| Grier, S | 1 |
| Vank, C | 1 |
| Cuperus, N | 1 |
| Van den Heuvel, L | 1 |
| Eliakim-Raz, N | 1 |
| Vuong, C | 1 |
| MacGowan, A | 1 |
| Addy, I | 1 |
| Pujol, M | 1 |
| Cobb, A | 1 |
| Rieger, E | 1 |
| Bell, J | 1 |
| Mallik, S | 1 |
| Zhao, Z | 1 |
| Szécsényi, Á | 1 |
| Li, G | 1 |
| Gascon, J | 1 |
| Pidko, EA | 1 |
| Zhang, GR | 1 |
| Wolker, T | 1 |
| Sandbeck, DJS | 1 |
| Munoz, M | 1 |
| Mayrhofer, KJJ | 1 |
| Cherevko, S | 1 |
| Etzold, BJM | 1 |
| Lukashuk, L | 1 |
| Yigit, N | 1 |
| Rameshan, R | 1 |
| Kolar, E | 1 |
| Teschner, D | 1 |
| Hävecker, M | 1 |
| Knop-Gericke, A | 1 |
| Schlögl, R | 1 |
| Föttinger, K | 1 |
| Rupprechter, G | 1 |
| Franconieri, F | 1 |
| Deshayes, S | 1 |
| de Boysson, H | 1 |
| Trad, S | 1 |
| Martin Silva, N | 1 |
| Terrier, B | 1 |
| Bienvenu, B | 1 |
| Galateau-Sallé, F | 1 |
| Emile, JF | 1 |
| Johnson, AC | 1 |
| Aouba, A | 1 |
| Vogt, TJ | 1 |
| Gevensleben, H | 1 |
| Dietrich, J | 1 |
| Kristiansen, G | 1 |
| Bootz, F | 1 |
| Landsberg, J | 1 |
| Goltz, D | 1 |
| Dietrich, D | 1 |
| Idorn, M | 1 |
| Skadborg, SK | 1 |
| Kellermann, L | 1 |
| Halldórsdóttir, HR | 1 |
| Holmen Olofsson, G | 1 |
| Met, Ö | 1 |
| Thor Straten, P | 1 |
| Johnson, LE | 1 |
| Brockstedt, D | 1 |
| Leong, M | 1 |
| Lauer, P | 1 |
| Theisen, E | 1 |
| Sauer, JD | 1 |
| McNeel, DG | 1 |
| Morandi, F | 1 |
| Marimpietri, D | 1 |
| Horenstein, AL | 1 |
| Bolzoni, M | 1 |
| Toscani, D | 1 |
| Costa, F | 1 |
| Castella, B | 1 |
| Faini, AC | 1 |
| Massaia, M | 1 |
| Pistoia, V | 1 |
| Giuliani, N | 1 |
| Malavasi, F | 1 |
| Qiu, J | 1 |
| Peng, S | 1 |
| Yang, A | 1 |
| Ma, Y | 1 |
| Han, L | 1 |
| Cheng, MA | 1 |
| Farmer, E | 1 |
| Hung, CF | 1 |
| Wu, TC | 1 |
| Modak, S | 1 |
| Le Luduec, JB | 1 |
| Cheung, IY | 1 |
| Goldman, DA | 1 |
| Ostrovnaya, I | 1 |
| Doubrovina, E | 1 |
| Basu, E | 1 |
| Kushner, BH | 1 |
| Kramer, K | 1 |
| Roberts, SS | 1 |
| O'Reilly, RJ | 1 |
| Cheung, NV | 1 |
| Hsu, KC | 1 |
| Salgarello, T | 1 |
| Giudiceandrea, A | 1 |
| Calandriello, L | 1 |
| Marangoni, D | 1 |
| Colotto, A | 1 |
| Caporossi, A | 1 |
| Falsini, B | 1 |
| Lefrançois, P | 1 |
| Xie, P | 1 |
| Wang, L | 2 |
| Tetzlaff, MT | 1 |
| Moreau, L | 1 |
| Watters, AK | 1 |
| Netchiporouk, E | 1 |
| Provost, N | 1 |
| Gilbert, M | 1 |
| Ni, X | 1 |
| Sasseville, D | 1 |
| Wheeler, DA | 1 |
| Duvic, M | 1 |
| Litvinov, IV | 1 |
| O'Connor, BJ | 1 |
| Fryda, NJ | 1 |
| Ranglack, DH | 1 |
| Yang, Y | 2 |
| Yang, J | 1 |
| Zhang, X | 2 |
| Grün, AL | 1 |
| Emmerling, C | 1 |
| Aumeeruddy-Elalfi, Z | 1 |
| Ismaël, IS | 1 |
| Hosenally, M | 1 |
| Zengin, G | 1 |
| Mahomoodally, MF | 1 |
| Dotsenko, A | 1 |
| Gusakov, A | 1 |
| Rozhkova, A | 1 |
| Sinitsyna, O | 1 |
| Shashkov, I | 1 |
| Sinitsyn, A | 1 |
| Hong, CE | 1 |
| Kim, JU | 1 |
| Lee, JW | 1 |
| Lee, SW | 1 |
| Jo, IH | 1 |
| Pandiyarajan, S | 1 |
| Premasudha, P | 1 |
| Kadirvelu, K | 1 |
| Wang, B | 1 |
| Luo, L | 1 |
| Wang, D | 1 |
| Ding, R | 1 |
| Hong, J | 1 |
| Caviezel, D | 1 |
| Maissen, S | 1 |
| Niess, JH | 1 |
| Kiss, C | 1 |
| Hruz, P | 1 |
| Pockes, S | 1 |
| Wifling, D | 1 |
| Keller, M | 1 |
| Buschauer, A | 1 |
| Elz, S | 1 |
| Santos, AF | 1 |
| Ferreira, IP | 1 |
| Pinheiro, CB | 1 |
| Santos, VG | 1 |
| Lopes, MTP | 1 |
| Teixeira, LR | 1 |
| Rocha, WR | 1 |
| Rodrigues, GLS | 1 |
| Beraldo, H | 1 |
| Lohar, S | 1 |
| Dhara, K | 1 |
| Roy, P | 1 |
| Sinha Babu, SP | 1 |
| Chattopadhyay, P | 1 |
| Sukwong, P | 1 |
| Sunwoo, IY | 1 |
| Lee, MJ | 1 |
| Ra, CH | 1 |
| Jeong, GT | 1 |
| Kim, SK | 2 |
| Huvinen, E | 1 |
| Eriksson, JG | 1 |
| Stach-Lempinen, B | 1 |
| Tiitinen, A | 1 |
| Koivusalo, SB | 1 |
| Malhotra, M | 1 |
| Suresh, S | 1 |
| Garg, A | 1 |
| Wei, L | 1 |
| Jiang, Y | 2 |
| Zhou, W | 1 |
| Liu, S | 1 |
| Liu, Y | 1 |
| Rausch-Fan, X | 1 |
| Liu, Z | 1 |
| Marques, WL | 1 |
| van der Woude, LN | 1 |
| Luttik, MAH | 1 |
| van den Broek, M | 1 |
| Nijenhuis, JM | 1 |
| Pronk, JT | 1 |
| van Maris, AJA | 1 |
| Mans, R | 1 |
| Gombert, AK | 1 |
| Xu, A | 1 |
| Sun, J | 1 |
| Li, J | 1 |
| Chen, W | 2 |
| Zheng, R | 1 |
| Han, Z | 1 |
| Ji, L | 1 |
| Shen, WQ | 1 |
| Bao, LP | 1 |
| Hu, SF | 1 |
| Gao, XJ | 1 |
| Xie, YP | 1 |
| Gao, XF | 1 |
| Huang, WH | 1 |
| Lu, X | 1 |
| Gostin, PF | 1 |
| Addison, O | 1 |
| Morrell, AP | 1 |
| Zhang, Y | 2 |
| Cook, AJMC | 1 |
| Liens, A | 1 |
| Stoica, M | 1 |
| Ignatyev, K | 1 |
| Street, SR | 1 |
| Wu, J | 1 |
| Chiu, YL | 1 |
| Davenport, AJ | 1 |
| Qiu, Z | 1 |
| Shu, J | 1 |
| Tang, D | 1 |
| Gao, X | 1 |
| Zhang, J | 3 |
| Huang, K | 1 |
| Wai, H | 1 |
| Du, K | 1 |
| Anesini, J | 1 |
| Kim, WS | 1 |
| Eastman, A | 1 |
| Micalizio, GC | 1 |
| Liang, JH | 1 |
| Huo, XK | 1 |
| Cheng, ZB | 1 |
| Sun, CP | 1 |
| Zhao, JC | 1 |
| Kang, XH | 1 |
| Zhang, TY | 1 |
| Chen, ZJ | 1 |
| Yang, TM | 1 |
| Wu, YY | 1 |
| Deng, XP | 1 |
| Zhang, YX | 1 |
| Salem, HF | 1 |
| Kharshoum, RM | 1 |
| Abou-Taleb, HA | 1 |
| AbouTaleb, HA | 1 |
| AbouElhassan, KM | 1 |
| Ohata, C | 1 |
| Ohyama, B | 1 |
| Kuwahara, F | 1 |
| Katayama, E | 1 |
| Nakama, T | 1 |
| Kobayashi, S | 1 |
| Kashiwagi, T | 1 |
| Kimura, J | 1 |
| Lin, JD | 1 |
| Liou, MJ | 1 |
| Hsu, HL | 1 |
| Leong, KK | 1 |
| Chen, YT | 1 |
| Wang, YR | 1 |
| Hung, WS | 1 |
| Lee, HY | 1 |
| Tsai, HJ | 1 |
| Tseng, CP | 1 |
| Alten, B | 1 |
| Yesiltepe, M | 1 |
| Bayraktar, E | 1 |
| Tas, ST | 1 |
| Gocmen, AY | 1 |
| Kursungoz, C | 1 |
| Martinez, A | 1 |
| Sara, Y | 1 |
| Huang, S | 2 |
| Adams, E | 1 |
| Van Schepdael, A | 1 |
| Wang, Q | 1 |
| Chung, CY | 1 |
| Yang, W | 1 |
| Yang, G | 1 |
| Chough, S | 1 |
| Chen, Y | 1 |
| Yin, B | 1 |
| Bhattacharya, R | 1 |
| Hu, Y | 1 |
| Saeui, CT | 1 |
| Yarema, KJ | 1 |
| Betenbaugh, MJ | 1 |
| Zhang, H | 1 |
| Patik, JC | 1 |
| Tucker, WJ | 1 |
| Curtis, BM | 1 |
| Nelson, MD | 1 |
| Nasirian, A | 1 |
| Park, S | 1 |
| Brothers, RM | 1 |
| Dohlmann, TL | 1 |
| Hindsø, M | 1 |
| Dela, F | 1 |
| Helge, JW | 1 |
| Larsen, S | 1 |
| Gayani, B | 1 |
| Dilhari, A | 1 |
| Wijesinghe, GK | 1 |
| Kumarage, S | 1 |
| Abayaweera, G | 1 |
| Samarakoon, SR | 1 |
| Perera, IC | 1 |
| Kottegoda, N | 1 |
| Weerasekera, MM | 1 |
| Nardi, MV | 1 |
| Timpel, M | 1 |
| Ligorio, G | 1 |
| Zorn Morales, N | 1 |
| Chiappini, A | 1 |
| Toccoli, T | 1 |
| Verucchi, R | 1 |
| Ceccato, R | 1 |
| Pasquali, L | 1 |
| List-Kratochvil, EJW | 1 |
| Quaranta, A | 1 |
| Dirè, S | 1 |
| Heo, K | 1 |
| Jo, SH | 1 |
| Shim, J | 1 |
| Kang, DH | 1 |
| Kim, JH | 1 |
| Park, JH | 1 |
| Akhtar, N | 1 |
| Saha, A | 1 |
| Kumar, V | 1 |
| Pradhan, N | 1 |
| Panda, S | 1 |
| Morla, S | 1 |
| Kumar, S | 1 |
| Manna, D | 1 |
| Wang, H | 1 |
| Xu, E | 1 |
| Yu, S | 1 |
| Li, D | 1 |
| Quan, J | 1 |
| Xu, L | 1 |
| Saslow, SA | 1 |
| Um, W | 1 |
| Pearce, CI | 1 |
| Bowden, ME | 1 |
| Engelhard, MH | 1 |
| Lukens, WL | 1 |
| Kim, DS | 1 |
| Schweiger, MJ | 1 |
| Kruger, AA | 1 |
| Adair, LS | 1 |
| Kuzawa, C | 1 |
| McDade, T | 1 |
| Carba, DB | 1 |
| Borja, JB | 1 |
| Liang, X | 2 |
| Song, W | 1 |
| Wang, K | 1 |
| Zhang, B | 1 |
| Peele, ME | 1 |
| Luo, HR | 1 |
| Chen, ZY | 1 |
| Fei, JJ | 1 |
| Du, ZJ | 1 |
| Yi, KJ | 1 |
| Im, WT | 1 |
| Kim, DW | 1 |
| Ji, X | 1 |
| Zhang, C | 1 |
| Xu, Z | 1 |
| Ding, Y | 1 |
| Song, Q | 1 |
| Li, B | 2 |
| Zhao, H | 1 |
| Lee, DW | 1 |
| Lee, H | 1 |
| Kwon, BO | 1 |
| Khim, JS | 1 |
| Yim, UH | 1 |
| Park, H | 1 |
| Park, B | 1 |
| Choi, IG | 1 |
| Kim, BS | 1 |
| Kim, JJ | 1 |
| Wang, JJ | 1 |
| Chen, Q | 1 |
| Li, YZ | 1 |
| Sakai, M | 1 |
| Yamaguchi, M | 1 |
| Nagao, Y | 1 |
| Kawachi, N | 1 |
| Kikuchi, M | 1 |
| Torikai, K | 1 |
| Kamiya, T | 1 |
| Takeda, S | 1 |
| Watanabe, S | 1 |
| Takahashi, T | 1 |
| Arakawa, K | 1 |
| Nakano, T | 1 |
| Rufo, S | 1 |
| Continentino, MA | 1 |
| Nikolaou, V | 1 |
| Plass, F | 1 |
| Planchat, A | 1 |
| Charisiadis, A | 1 |
| Charalambidis, G | 1 |
| Angaridis, PA | 1 |
| Kahnt, A | 1 |
| Odobel, F | 1 |
| Coutsolelos, AG | 1 |
| Fuentes, I | 1 |
| García-Mendiola, T | 1 |
| Sato, S | 1 |
| Pita, M | 1 |
| Nakamura, H | 1 |
| Lorenzo, E | 1 |
| Teixidor, F | 1 |
| Marques, F | 1 |
| Viñas, C | 1 |
| Liu, F | 1 |
| Qi, P | 1 |
| Zhang, L | 1 |
| Quinn, JA | 4 |
| Jiang, SX | 3 |
| Reardon, DA | 3 |
| Desjardins, A | 3 |
| Vredenburgh, JJ | 3 |
| Rich, JN | 3 |
| Gururangan, S | 3 |
| Friedman, AH | 3 |
| Bigner, DD | 3 |
| Sampson, JH | 3 |
| McLendon, RE | 4 |
| Herndon, JE | 4 |
| Walker, A | 2 |
| Friedman, HS | 4 |
| Koch, D | 1 |
| Hundsberger, T | 1 |
| Boor, S | 1 |
| Kaina, B | 1 |
| Weingart, J | 1 |
| Grossman, SA | 1 |
| Carson, KA | 1 |
| Fisher, JD | 1 |
| Delaney, SM | 1 |
| Rosenblum, ML | 1 |
| Olivi, A | 1 |
| Judy, K | 1 |
| Tatter, SB | 1 |
| Dolan, ME | 2 |
| Pluda, J | 1 |
| Ewesuedo, RB | 1 |
| Long, L | 1 |
| Cokgor, I | 1 |
| Colvin, OM | 1 |
| Haglund, MM | 1 |
| Ashley, DM | 1 |
| Sampson, J | 1 |
| Pegg, AE | 1 |
| Moschel, RC | 1 |
| Provenzale, JM | 1 |
| Stewart, ES | 1 |
| Tourt-Uhlig, S | 1 |
| Garcia-Turner, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Trial of Temodar Plus O6-Benzylguanine (O6-BG) (NSC 637037) in the Treatment of Patients With Newly Diagnosed (Part 1) or Recurrent/Progressive (Parts 1 and 2) Cerebral Anaplastic Gliomas[NCT00006474] | Phase 1 | 0 participants | Interventional | 2001-03-31 | Completed | ||
| Phase I GLIADEL and Continuous Infusion of Intravenous O6-Benzylguanine Trial in Patients With Recurrent Malignant Glioma[NCT00004892] | Phase 1 | 0 participants | Interventional | 2000-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for o(6)-benzylguanine and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Resi | 2009 |
Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; G | 2009 |
Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Dacarbaz | 2009 |
Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; | 2007 |
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Central Nervous Syst | 2000 |
1 other study available for o(6)-benzylguanine and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neop | 2007 |