o(6)-benzylguanine has been researched along with Digestive System Neoplasms in 1 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules." | 2.69 | O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. ( Gerson, SL; Haaga, J; Hoppel, CL; Ingalls, ST; Liu, L; Majka, S; Pluda, JM; Spiro, TP; Willson, JK, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spiro, TP | 1 |
| Gerson, SL | 1 |
| Liu, L | 1 |
| Majka, S | 1 |
| Haaga, J | 1 |
| Hoppel, CL | 1 |
| Ingalls, ST | 1 |
| Pluda, JM | 1 |
| Willson, JK | 1 |
1 trial available for o(6)-benzylguanine and Digestive System Neoplasms
| Article | Year |
|---|---|
O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy; Biotransformation; Breast Neoplasms; Carmust | 1999 |