o(6)-benzylguanine has been researched along with Central Nervous System Neoplasm in 6 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report the results of the first pharmacokinetic study in pediatric patients of O(6)-benzylguanine (O(6)BG), which irreversibly inactivates the DNA repair protein alkylguanine-alkyltransferase, thus enhancing the cytotoxicity of nitrosoureas." | 2.71 | Pharmacokinetics of O(6)-benzylguanine in pediatric patients with central nervous system tumors: a pediatric oncology group study. ( Adams, D; Aleksic, A; Berg, S; Bernstein, M; Blaney, S; Neville, K; Thompson, P, 2004) |
| "Twenty-three patients were treated (22 with glioblastoma multiforme and one with anaplastic astrocytoma)." | 2.69 | Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. ( Ashley, DM; Bigner, DD; Cokgor, I; Colvin, OM; Dolan, ME; Ewesuedo, RB; Friedman, AH; Friedman, HS; Garcia-Turner, AM; Haglund, MM; Herndon, JE; Long, L; McLendon, RE; Moschel, RC; Pegg, AE; Pluda, J; Provenzale, JM; Quinn, JA; Rich, JN; Sampson, J; Stewart, ES; Tourt-Uhlig, S, 2000) |
| " Pretreatment of mice with O6-benzylguanine increased temozolomide-induced mortality, requiring reduction of the dosage from 1200 to 750 mg/m2 on the single-day regimen." | 1.29 | Activity of temozolomide in the treatment of central nervous system tumor xenografts. ( Bigner, DD; Catino, JJ; Dolan, ME; Friedman, HS; Keir, S; Marcelli, S; Pegg, AE; Schold, SC, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friedman, HS | 4 |
| Keir, S | 2 |
| Pegg, AE | 4 |
| Houghton, PJ | 1 |
| Colvin, OM | 2 |
| Moschel, RC | 3 |
| Bigner, DD | 4 |
| Dolan, ME | 4 |
| Neville, K | 2 |
| Blaney, S | 1 |
| Bernstein, M | 2 |
| Thompson, P | 1 |
| Adams, D | 1 |
| Aleksic, A | 1 |
| Berg, S | 1 |
| Adams, DM | 1 |
| Zhou, T | 1 |
| Berg, SL | 1 |
| Blaney, SM | 1 |
| Marcelli, S | 1 |
| Catino, JJ | 1 |
| Schold, SC | 1 |
| Keir, ST | 1 |
| Lawless, A | 1 |
| Pluda, J | 1 |
| Quinn, JA | 1 |
| Ewesuedo, RB | 1 |
| Long, L | 1 |
| Friedman, AH | 1 |
| Cokgor, I | 1 |
| Haglund, MM | 1 |
| Ashley, DM | 1 |
| Rich, JN | 1 |
| Sampson, J | 1 |
| McLendon, RE | 1 |
| Provenzale, JM | 1 |
| Stewart, ES | 1 |
| Tourt-Uhlig, S | 1 |
| Garcia-Turner, AM | 1 |
| Herndon, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Trial of 06-BG and BCNU in Children With CNS Tumors[NCT00003765] | Phase 1 | 36 participants (Actual) | Interventional | 1999-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for o(6)-benzylguanine and Central Nervous System Neoplasm
| Article | Year |
|---|---|
Pharmacokinetics of O(6)-benzylguanine in pediatric patients with central nervous system tumors: a pediatric oncology group study.
Topics: Adolescent; Adult; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Central Nervous System | 2004 |
Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone | 2008 |
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Central Nervous Syst | 2000 |
3 other studies available for o(6)-benzylguanine and Central Nervous System Neoplasm
| Article | Year |
|---|---|
O6-benzylguanine-mediated enhancement of chemotherapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Camptothecin; Carmustine; Central | 2002 |
Activity of temozolomide in the treatment of central nervous system tumor xenografts.
Topics: Animals; Carmustine; Central Nervous System Neoplasms; Dacarbazine; Female; Guanine; Humans; Male; M | 1995 |
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
Topics: Animals; Antineoplastic Agents; Carmustine; Central Nervous System Neoplasms; Clinical Trials as Top | 2000 |