o(6)-benzylguanine has been researched along with Cancer of Colon in 13 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murakami, J | 1 |
| Lee, YJ | 1 |
| Kokeguchi, S | 1 |
| Tsujigiwa, H | 1 |
| Asaumi, J | 1 |
| Nagatsuka, H | 1 |
| Fukui, K | 1 |
| Kuroda, M | 1 |
| Tanaka, N | 1 |
| Matsubara, N | 1 |
| Magull-Seltenreich, A | 1 |
| Zeller, WJ | 1 |
| Chae, MY | 1 |
| McDougall, MG | 1 |
| Dolan, ME | 4 |
| Swenn, K | 1 |
| Pegg, AE | 2 |
| Moschel, RC | 5 |
| Grindey, GB | 1 |
| Gerson, SL | 6 |
| Zborowska, E | 2 |
| Norton, K | 1 |
| Gordon, NH | 2 |
| Willson, JK | 2 |
| Liu, L | 5 |
| Markowitz, S | 1 |
| Phillips, WP | 1 |
| Markowitz, SD | 1 |
| Zaidi, NH | 1 |
| Reese, JS | 2 |
| Davis, BM | 3 |
| Koç, ON | 1 |
| Majczenko, KJ | 1 |
| Wali, RK | 1 |
| Skarosi, S | 1 |
| Hart, J | 1 |
| Zhang, Y | 1 |
| Nguyen, L | 1 |
| Mustafi, R | 1 |
| Brasitus, TA | 1 |
| Bissonnette, M | 1 |
| Pauly, GT | 1 |
| Schwartz, S | 1 |
| Mitchell, RB | 1 |
13 other studies available for o(6)-benzylguanine and Cancer of Colon
| Article | Year |
|---|---|
Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neo | 2007 |
Sensitization of human colon tumour cell lines to carmustine by depletion of O6-alkylguanine-DNA alkyltransferase.
Topics: Carmustine; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Guanine; Humans; M | 1995 |
Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase.
Topics: Colonic Neoplasms; Guanine; Humans; Methyltransferases; Molecular Structure; O(6)-Methylguanine-DNA | 1994 |
Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Topics: Animals; Carmustine; Cell Division; Colonic Neoplasms; Drug Synergism; Female; Guanine; Humans; Meth | 1993 |
Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; C | 1993 |
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Dama | 1996 |
O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
Topics: Animals; Antineoplastic Agents; Carmustine; Colonic Neoplasms; DNA Repair; Drug Resistance, Neoplasm | 1997 |
Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Da | 1999 |
DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow Transplantation; Carmustine; Cell Division; | 1999 |
Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Enzyme Inhibitors; Genes, ras; Guanine; Kinet | 1999 |
Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.
Topics: Base Pair Mismatch; Colonic Neoplasms; Escherichia coli; Genetic Vectors; Guanine; Humans; Kidney; L | 2001 |
Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
Topics: Adaptor Proteins, Signal Transducing; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, A | 2002 |
Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
Topics: Animals; Carmustine; Colonic Neoplasms; DNA; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance; D | 1992 |