o(6)-benzylguanine has been researched along with Breast Cancer in 5 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
| Excerpt | Relevance | Reference |
|---|---|---|
| "Novel radiolabeled O(6)-benzylguanine derivatives, 6-O-[(11)C]-[(methoxymethyl)benzyl]guanines ([(11)C]p-O(6)-MMBG, 1a; [(11)C]m-O(6)-MMBG, 1b; ([(11)C]o-O(6)-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase (AGT)." | 7.72 | Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT. ( Erickson, LC; Fei, X; Hutchins, GD; Liu, X; Ohannesian, DW; Stone, KL; Wang, JQ; Zheng, QH, 2003) |
| "MCF-7 human breast cancer cells possess high levels of O6-alkylguanine-DNA alkyltransferase and moderate levels of glutathione, and are more resistant to chloroethylnitrosoureas (CNUs) than cells with low levels of either molecule." | 7.69 | Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer. ( Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME, 1994) |
| "We treated MCF-7 breast cancer cells three times with cytotoxic concentrations of BG + BCNU to isolate a population of MCF-7 cells possessing BG + BCNU resistance (BBR)." | 5.30 | Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer. ( Gerson, SL; Phillips, WP, 1999) |
| "Novel radiolabeled O(6)-benzylguanine derivatives, 6-O-[(11)C]-[(methoxymethyl)benzyl]guanines ([(11)C]p-O(6)-MMBG, 1a; [(11)C]m-O(6)-MMBG, 1b; ([(11)C]o-O(6)-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase (AGT)." | 3.72 | Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT. ( Erickson, LC; Fei, X; Hutchins, GD; Liu, X; Ohannesian, DW; Stone, KL; Wang, JQ; Zheng, QH, 2003) |
| "MCF-7 human breast cancer cells possess high levels of O6-alkylguanine-DNA alkyltransferase and moderate levels of glutathione, and are more resistant to chloroethylnitrosoureas (CNUs) than cells with low levels of either molecule." | 3.69 | Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer. ( Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME, 1994) |
| "Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules." | 2.69 | O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. ( Gerson, SL; Haaga, J; Hoppel, CL; Ingalls, ST; Liu, L; Majka, S; Pluda, JM; Spiro, TP; Willson, JK, 1999) |
| "In tamoxifen-resistant breast cancer cells, BG alone or in combination with antiestrogen (tamoxifen [TAM]/ICI 182,780 [fulvestrant, Faslodex]) therapy enhances p53 upregulated modulator of apoptosis (PUMA) expression, cytochrome C release and poly (ADP-ribose) polymerase (PARP) cleavage, all indicative of apoptosis." | 1.38 | MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy. ( Baidas, S; Baker, CH; Bobustuc, GC; Caparas, ML; Constantino, SM; Isley, B; Jeudy, S; Konduri, SD; Limaye, A; Maddipatla, S; Shah, N; Smith, JS; Srivenugopal, KS, 2012) |
| "We treated MCF-7 breast cancer cells three times with cytotoxic concentrations of BG + BCNU to isolate a population of MCF-7 cells possessing BG + BCNU resistance (BBR)." | 1.30 | Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer. ( Gerson, SL; Phillips, WP, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Zheng, QH | 1 |
| Fei, X | 1 |
| Wang, JQ | 1 |
| Ohannesian, DW | 1 |
| Erickson, LC | 1 |
| Stone, KL | 1 |
| Hutchins, GD | 1 |
| Bobustuc, GC | 1 |
| Smith, JS | 1 |
| Maddipatla, S | 1 |
| Jeudy, S | 1 |
| Limaye, A | 1 |
| Isley, B | 1 |
| Caparas, ML | 1 |
| Constantino, SM | 1 |
| Shah, N | 1 |
| Baker, CH | 1 |
| Srivenugopal, KS | 1 |
| Baidas, S | 1 |
| Konduri, SD | 1 |
| Gerson, SL | 3 |
| Berger, SJ | 1 |
| Varnes, ME | 1 |
| Donovan, C | 1 |
| Spiro, TP | 1 |
| Liu, L | 1 |
| Majka, S | 1 |
| Haaga, J | 1 |
| Hoppel, CL | 1 |
| Ingalls, ST | 1 |
| Pluda, JM | 1 |
| Willson, JK | 1 |
| Phillips, WP | 1 |
1 trial available for o(6)-benzylguanine and Breast Cancer
| Article | Year |
|---|---|
O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biopsy; Biotransformation; Breast Neoplasms; Carmust | 1999 |
4 other studies available for o(6)-benzylguanine and Breast Cancer
| Article | Year |
|---|---|
Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT.
Topics: Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Guanine; Humans; O(6)-Methylguanine-DNA Methy | 2003 |
MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumo | 2012 |
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathio | 1994 |
Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; | 1999 |