o(6)-benzylguanine has been researched along with Arachnoidal Cerebellar Sarcoma, Circumscribed in 5 studies
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to determine whether resistance to the activity of nitrosourea (the drug BCNU) in BCNU-resistant human medulloblastoma (D341 Med) and human glioblastoma multiforme (D-456 MG) can be reversed by the methylating agent streptozocin and the O6-substituted guanines O6-methylguanine and O6-benzylguanine." | 3.68 | Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. ( Bigner, DD; Dolan, ME; Felker, GM; Friedman, HS; Moschel, RC; Pegg, AE; Rich, J; Schold, SC, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shankar, S | 1 |
| Zalutsky, MR | 1 |
| Friedman, H | 1 |
| Vaidyanathan, G | 1 |
| Felker, GM | 2 |
| Friedman, HS | 2 |
| Dolan, ME | 3 |
| Moschel, RC | 2 |
| Schold, C | 1 |
| Rhines, LD | 1 |
| Sampath, P | 1 |
| Tyler, BM | 1 |
| Brem, H | 1 |
| Weingart, J | 1 |
| Pegg, AE | 1 |
| Rich, J | 1 |
| Bigner, DD | 1 |
| Schold, SC | 1 |
| Silber, JR | 1 |
| Bobola, MS | 1 |
| Ewers, TG | 1 |
| Muramoto, M | 1 |
| Berger, MS | 1 |
5 other studies available for o(6)-benzylguanine and Arachnoidal Cerebellar Sarcoma, Circumscribed
| Article | Year |
|---|---|
Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.
Topics: Animals; Benzoflavones; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; Guanine; Humans; Iod | 2006 |
Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Drug Synergism | 1993 |
O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Ne | 2000 |
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
Topics: Animals; Carmustine; Drug Resistance; Female; Glioblastoma; Guanine; Humans; Male; Medulloblastoma; | 1992 |
O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines.
Topics: Carmustine; Cell Survival; Cerebellar Neoplasms; Drug Resistance; Guanine; Humans; Medulloblastoma; | 1992 |