nystatin-a1 and Vulvovaginitis

Topics: Adult; Candidiasis; Clinical Laboratory Techniques; Diagnosis, Differential; Female; Haemophilus Infections; Humans; Metronidazole; Nystatin; Recurrence; Sulfonamides; Trichomonas Vaginitis; Vaginal Diseases; Vaginitis; Vulvovaginitis

The GENIE study was performed to evaluate the effectiveness and systemic exposure to oxytetracycline in local treatment of unspecific and mixed vulvovaginal infections characterized by vaginal discharge with Geonistin® vaginal tablets (100 mg oxytetracycline and 100 000 IU nystatin). The total number of subjects enrolled was 189. The treatment had beneficial effects in 100% of the study population. According to the Nugent score, the treatment had a positive effect in 89.2% of participants. The microbiological cure rate was 78.8%. Oxytetracycline concentration levels were from 13.3 to 32.2 ng/mL in 11 out of 15 subjects, and in four subjects the levels were below 10 ng/mL. Geonistin® had a beneficial effect on the unspecific and mixed vulvovaginal infections characterized by vaginal discharge in all efficacy and safety outcomes. Microbiological and the Nugent score efficacy measures confirmed clinical effectiveness. Beneficial efficacy results were achieved with only a few non-serious adverse events.

Topics: Adolescent; Adult; Anti-Bacterial Agents; Antifungal Agents; Female; Humans; Middle Aged; Nystatin; Prospective Studies; Tablets; Treatment Outcome; Vaginal Creams, Foams, and Jellies; Vulvovaginitis; Young Adult

The evaluation of combined and miscellaneous vulvovaginal infections incidence and their treatment with combined vaginal products containing nifuratel and nystatin.. Prospective study.. Gynecologic outpatient department LEVRET, Prague; Laboratories of Microbiology AescuLab, Prague.. 70 consecutive patients were examined with complaint of vaginal fluor and/or pruritus. We established macroscopic features of fluor, pH, amine test and mounts stained with Giemsa and Gram. We qualified the cases with more diagnostic criteria (mycosis, lactobacillosis, anaerobic vaginosis, aerobic vaginitis) as combined infection, those with no diagnostic criteria as miscellaneous. We treated all patients with vaginal tablets nystatin + nifuratel (Macmiror complex). We prescribed clotrimazol cream, if pruritus was present. We evaluated withdrawals of symptoms and relapses during 3 months after treatment.. Combined infection was found in 21 patients from 70 (30%). The most frequent combination was that of mycosis and aerobic vaginitis (13/70, 18.6%) or mycosis and anaerobic vaginosis (4/70, 5.7%); 11 patients fulfilled criteria of no diagnosis. We concluded them as "miscelaneous". The treatment was successful in all cases, 10 women relapsed in 3 months.. Combined vaginal infection findings are present very often (30%), likewise miscellaneous ones (15%) occur. The treatment of these women in successful with vaginal tablets with nystatin + nifuratel.

Topics: Administration, Intravaginal; Adult; Anti-Bacterial Agents; Antifungal Agents; Antitrichomonal Agents; Candidiasis, Vulvovaginal; Clotrimazole; Drug Combinations; Female; Humans; Middle Aged; Nifuratel; Nystatin; Trichomonas Vaginitis; Vaginosis, Bacterial; Vulvovaginitis

The aim: To determine the distribution of Candida spp. within different age groups and contraceptive methods in women with vulvovaginitis, as well as the susceptibility of Candida spp. to commonly used antifungals.. Materials and methods: High vaginal swabs were taken from 98 women aged 18 to 50 with vulvovaginitis who used contraceptives and attended the Women and Children Hospital in Al-Diwaniyah; after diagnosis of Candida species, the sensitivity of Candida spp. to some antifungals was studied.. Results: The results showed (43/98) women (43.87%) used IUD, (15/98) women (15.30%) used birth control pills, (7/98) women (7.14%) used an injection of contraceptive, (5/98) women (5.10%) used contraceptive suppositories, and (28/98) women (28.57%) did not use any contraceptives. Candida spp. was found in (48/83) specimens (57.831%) from women who used contraceptives and only (11/28) specimens (39.285%) from women who did not use contraceptives. Only (59/98) vaginal specimens tested positive for vaginal candidiasis, (28/59) isolates (47.457%) for C. albicans, then (16/59) isolates for C. glabrata (27.118%), (9/59) isolates (15.254%) for C. tropicalis and (6/59) isolates (10.169%) for C. krusei. Nystatin was the best treatment for all Candida spp. under study, and the MIC was 6.25, and the MFC was 50 for all antifungals and Candida species under study.. Conclusions: C. albicans was the most prevalent cause of vulvovaginal candidiasis, while C. glabrata was the most common non-albicans species in women aged 26 to 35; using an IUD was associated with an increased infection of vulvovaginal candidiasis, and nystatin was the most effective treatment.

Topics: Antifungal Agents; Candida; Candida albicans; Candidiasis, Vulvovaginal; Child; Contraception; Contraceptive Agents; Female; Humans; Nystatin; Pichia; Suppositories; Vulvovaginitis

The group of experts representing the Polish Gynecologic Society has issued this statement based on the review of available literature on the potential benefits of the use of Macmiror Complex 500 in obstetrical and gynecologic practice. Mixed Vaginitis (MV) eg. the vaginal infection caused by at least two out of the triad of pathogens (fungi, bacteria and Trichomonas Vaginalis [TV]), constitutes the type of vaginitis which is underestimated as for its prevalence. Mixed pathogens are responsible for as much as one third of all vaginal infections. Macmiror Complex 500 contains two active ingredients: nifuratel and nystatin. Macmiror Complex 500 affects all common causes of vulvovaginitis, i.e. bacteria, yeasts and TV. At the same time, it is not effective against Lactobacillus spp., which is a clear advantage in the treatment of vaginal infections. The antibacterial spectrum of nifuratel includes aerobic and anaerobic bacteria. Moreover nifuratel is effective against Chlamydia trachomatis and Mycoplasma spp., it has an anti-trichomonal effect comparable to metranidazole and shows certain activity against Candida spp. Nystatin is effective against Candida albicans and is even very effective against Candida glabrata which is usually more resistant to imidazole antifungal agents. Nystatin's importance is rising due to the current increase of candidoses caused by non-albicans types. This increase is especially perceptible in recurring candidoses. The review of the available literature on the effectiveness of Macmiror Complex 500 in the OB/GYN practice leads to the following conclusions: the exeptionally broad antibacterial and antifungal and trichomonicidal activity of this formulation makes it a drug of choice in cases where MV is suspected. The possibility to treat both partners, favorable safety profile in pregnant patients and the availability of both vaginal ovules and the cream with applicator makes this drug an effective and suitable treatment option in obstetrical and gynecologic practice.

Topics: Antifungal Agents; Antitrichomonal Agents; Drug Combinations; Female; Gynecology; Humans; National Health Programs; Nifuratel; Nystatin; Obstetrics; Poland; Pregnancy; Quality Assurance, Health Care; Societies, Medical; Trichomonas Vaginitis; Vulvovaginitis; Women's Health

Topics: Anti-Infective Agents; Drug Combinations; Female; Humans; Nifuratel; Nystatin; Vulvovaginitis

Topics: Adult; Antifungal Agents; Candidiasis, Cutaneous; Female; Humans; Infant, Newborn; Male; Nystatin; Pregnancy; Pregnancy Complications, Infectious; Vulvovaginitis

A 64-year-old woman had severe vulvovaginitis develop while she was receiving intravaginal nystatin therapy for Candida glabrata infection. Mucocutaneous adverse effects have rarely been reported with nystatin despite long years of use. This complication should be included in the differential diagnosis of clinical failure of intravaginal nystatin therapy.

Topics: Administration, Intravaginal; Anti-Inflammatory Agents; Antifungal Agents; Betamethasone; Candidiasis; Edema; Erythema; Female; Humans; Hydrocortisone; Middle Aged; Nystatin; Vulvovaginitis

Topics: Adolescent; Anti-Bacterial Agents; Antifungal Agents; Antitrichomonal Agents; Child; Drug Therapy, Combination; Female; Humans; Nifuratel; Nystatin; Vulvovaginitis

Topics: Boric Acids; Candidiasis; Capsules; Double-Blind Method; Female; Humans; Nystatin; Vulvovaginitis

The therapeutic effectiveness of poliene antibiotics, such as nystatin, polyfungin, and pimafucin, was comparatively analysed in the context of mycoses of the genital organs of girls in various periods of development. Early detection of fungi in genital organs, the oral cavity, rectum, and urethra is of great importance to mycosis treatment of children. Whenever antimycotic treatment is followed by recurrent outbreaks, all persons in the child's closer environment have to be examined at any rate.

Topics: Adolescent; Anal Canal; Child; Child, Preschool; Female; Genital Diseases, Female; Humans; Infant; Male; Mouth; Mycoses; Natamycin; Nystatin; Polyenes; Urethra; Vagina; Vulvovaginitis

Topics: Candida albicans; Female; Humans; Metronidazole; Nystatin; Trichomonas; Vulvovaginitis

Although previous reports have implicated Shigella flexneri in resistant or chronic cases of vulvovaginitis in children, no authors have described the clinical findings of this condition. The report presents four cases of persistent vulvovaginitis in prepubertal Indian girls from different reservation communities in Arizona. S. flexneri was isolated in pure culture from the vaginal discharge of each patient. All four cases were characterized by a prolonged vaginitis with a bloody, purulent discharge which responded poorly or not at all to various topical modes of therapy for nonspecific vaginitis. Three cases cleared completely when treated with orally given ampicillin for one week. The striking similarity of these cases suggests that chronic Shigella vulvovaginitis is a recognizable clinical entity and should be considered in the differential diagnosis of persistent vaginitis in children, especially in those from communities where Shigella is endemic.

Topics: Ampicillin; Arizona; Child; Child, Preschool; Enterobacteriaceae Infections; Estrogens; Female; Humans; Indians, North American; Nitrofurantoin; Nystatin; Shigella flexneri; Sulfisoxazole; Sulfonamides; Vulvovaginitis

Topics: Adult; Antitrichomonal Agents; Arsenicals; Candidiasis; Drug Combinations; Female; Humans; Middle Aged; Neomycin; Nystatin; Polymyxins; Silicones; Trichomonas Vaginitis; Vulvovaginitis

Topics: Adolescent; Adult; Aged; Antifungal Agents; Benzyl Compounds; Candida; Candida albicans; Candidiasis; Child; Ethers; Female; Humans; Imidazoles; Middle Aged; Nitrates; Nystatin; Vulvovaginitis

Topics: Adult; Alcohols; Behcet Syndrome; Candidiasis, Vulvovaginal; Colposcopy; Condylomata Acuminata; Cryosurgery; Female; Fluorouracil; Genital Diseases, Female; Herpes Labialis; Humans; Lichen Planus; Menstruation Disturbances; Neurodermatitis; Nystatin; Podophyllin; Progestins; Testosterone; Triamcinolone Acetonide; Trichomonas Vaginitis; Vaginal Smears; Vulvovaginitis

Topics: Adrenal Cortex Hormones; Adult; Contraceptives, Oral; Female; Humans; Mycoses; Nystatin; Vulvovaginitis

Topics: Adolescent; Candidiasis, Vulvovaginal; Child; Diabetes Mellitus; Drug Therapy; Female; Gonorrhea; Humans; Infant; Infant, Newborn; Metronidazole; Nystatin; Pregnancy; Trichomonas Vaginitis; Uterine Cervicitis; Vaginitis; Varicose Veins; Vulvar Neoplasms; Vulvitis; Vulvovaginitis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Candidiasis, Vulvovaginal; Child; Female; Humans; Imidazoles; Metronidazole; Nystatin; Trichomonas Vaginitis; Vulvovaginitis

Topics: Anthelmintics; Candidiasis, Vulvovaginal; Child; Female; Humans; Neisseria gonorrhoeae; Nystatin; Oxyuriasis; Penicillins; Streptococcal Infections; Streptomycin; Trichomonas Vaginitis; Virus Diseases; Vulvovaginitis

Topics: Candidiasis, Vulvovaginal; Child; Female; Humans; Infant; Iodides; Nystatin; Silver Nitrate; Vitamins; Vulvovaginitis

Topics: Female; Fungi; Humans; Mycoses; Nystatin; Vulvovaginitis

Topics: Candidiasis; Candidiasis, Vulvovaginal; Female; Humans; Nystatin; Organic Chemicals; Vaginitis; Vulvovaginitis

Topics: Candida; Candidiasis, Vulvovaginal; Female; Humans; Nystatin; Vaginitis; Vulvovaginitis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Candidiasis; Candidiasis, Vulvovaginal; Female; Humans; Intraabdominal Infections; Nystatin; Vaginitis; Vulvovaginitis

Topics: Anti-Bacterial Agents; Candidiasis; Candidiasis, Vulvovaginal; Female; Humans; Nystatin; Vaginitis; Vulvitis; Vulvovaginitis