nystatin-a1 and Stomatitis

Oral mucositis is a frequent and potentially severe complication of radiation or chemotherapy for cancer. Associated with atrophy and ulceration of the oral mucosa is an increased risk of infection, and the most common pathogenic agent is Candida. Chitosan is an excellent candidate for the treatment of oral mucositis. Its bioadhesive and antimicrobial properties offer the palliative effects of an occlusive dressing and the potential for delivering drugs, including anti-candidal agents. The aim of this study was to develop an occlusive bioadhesive system for prophylaxis and/or treatment of oral mucositis. Gel and film formulations were prepared using chitosans at different molecular weights and in different solvents. Nystatin, which is considered as a prophylactic agent for oral mucositis was incorporated into the formulations. The in vitro release of nystatin from the formulations was decreased with the increasing molecular weight of chitosan. The effect of the formulations was investigated in vivo in hamsters with chemotherapy-induced mucositis. Mucositis scores in groups treated with nystatin incorporated into gel and suspension formulations were significantly lower (p < 0.05) than those treated with the chitosan gel alone. Survival of animals in the treated groups was higher than that in the control group. The retention time and distribution of the gels in the oral cavity were investigated in healthy volunteers. A faster distribution of nystatin in the oral cavity was obtained using the suspension compared to the gels, but the nystatin saliva level decreased rapidly as well. A drug concentration above the minimum inhibitory concentration (MIC) value for Candida albicans (0.14 microg/ml) was maintained for longer periods of time at the application site (90 min) than at the contralateral site (45 min) in the oral cavity.

Topics: Adult; Animals; Antifungal Agents; Biological Availability; Body Weight; Chitosan; Cricetinae; Cross-Over Studies; Drug Delivery Systems; Drug Therapy, Combination; Fluorouracil; Gels; Histocytochemistry; Humans; Lactic Acid; Male; Mesocricetus; Mouth Mucosa; Nystatin; Polyphosphates; Saliva; Stomatitis; Survival Rate; Treatment Outcome; Water

Oral mucositis is a frequent complication of radiochemotherapy. The origin of radiation-induced mucosa lesions is of iatrogenic nature although further development of mucositis is essentially influenced by infection. It can be assumed that disinfection measures should decrease the severity of mucositis induced by radiochemotherapy. Therefore, in a prospective randomised study the efficacy of prophylactic oral rinsing with a disinfection agent was investigated.. An open, randomised, prospective comparative trial was conducted with 40 patients undergoing radiochemotherapy of head and neck region due to malignant disease. The treatment scheme consisted of irradiation to tumor region and adjacent lymph nodes with a total dose of 71.3 Gy and simultaneous chemotherapy with carboplatin (60 mg/m2) on days 1 to 5 and 29 to 34. In all patients, a prophylaxis of mucositis with nystatine, rutosides, panthenol and immunoglobulin was undertaken. In addition, 20 patients rinsed oral cavity 4 times daily with povidone-iodine-solution, the comparative group rinsed with sterile water. Clinical examination of the oral mucosa was performed weekly. Onset, grading and duration of mucositis were used as main variables.. Clinically manifested oral mucositis was observed in 14 patients of the iodine group (mean grading: 1.0) and all 20 patients of the control group (mean grading: 3.0). Total duration (mean) of clinically observed mucositis was 2.75 weeks in treatment patients and 9.25 in control patients. Median AUC (area under curve for grade vs duration) was 2.5 in iodine rinsing patients and 15.75 in control patients. All differences found between the 2 groups were statistically significant. Increased iodine incorporation was not observed. A pathological increase of thyroid hormone levels in the iodine group was not found.. The gained results indicate that incidence, severity and duration of radiochemotherapy-induced mucositis can be significantly reduced by oral rinsing with povidone-iodine performed additionally to the standard prophylaxis scheme.

Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antifungal Agents; Antineoplastic Agents; Carboplatin; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Immunization, Passive; Male; Middle Aged; Mouthwashes; Nystatin; Ointments; Pantothenic Acid; Povidone-Iodine; Prospective Studies; Radiotherapy; Radiotherapy Dosage; Rutin; Stomatitis; Time Factors; Vasodilator Agents

In an open study, the efficacy of povidone-iodine in the prophylaxis of mucositis during antineoplastic radiochemotherapy was determined. 40 patients were randomly assigned to a treatment or control group (each 20 patients). All patients received standard prophylaxis of mucositis with nystatin, dexpanthenol, rutoside and immunoglobulin. In addition, the patients of the treatment group performed 4 times daily rinsing with povidone-iodine, the control patients with sterile water. Clinical examination of the oral mucosa was performed weekly during the radiation period and up to 6 weeks after the end of therapy. Oral mucositis was observed in 14 patients of the treatment group (mean grading: 1.0) and in all 20 patients of the control group (mean grading: 3.0). The mean onset of mucositis was after 2.25 weeks in treatment patients and 1.5 weeks in control patients. The mean total duration of mucositis was 2.75 weeks in treatment patients and 9.25 weeks in control patients. The mean AUC values were 2.5 in treatment patients and 15.75 in control patients. All findings were statistically significantly different between the two groups. It is concluded that rinsing with povidone-iodine reduces the incidence, severity and duration of oral mucositis during antineoplastic radiochemotherapy.

Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Chemoprevention; Combined Modality Therapy; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Immunization, Passive; Incidence; Iodophors; Male; Middle Aged; Mouthwashes; Nystatin; Pantothenic Acid; Povidone-Iodine; Radiotherapy; Rutin; Stomatitis; Time Factors; Vasodilator Agents

Topics: Adolescent; Adult; Amphotericin B; Antifungal Agents; Child; Child, Preschool; Female; Humans; Male; Mouth Mucosa; Nystatin; Oral Hygiene; Patient Compliance; Stomatitis

The goal of reducing oral complications during chemotherapy and bone marrow transplantation has received attention at several centers. The current randomized study of 86 adults with leukemia treated with chemotherapy or bone marrow transplantation assessed the potential role of chlorhexidine, nystatin, and saline solution rinses to reduce the findings of oral mucositis, gingivitis, and oral infection. The results of this study did not show a reduction in mucositis with the use of these rinses. However, potential bacterial and fungal pathogens were identified less frequently in the patients using chlorhexidine rinse.

Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bacteremia; Bacteria; Bone Marrow Transplantation; Candidiasis, Oral; Chlorhexidine; Drug Combinations; Female; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Middle Aged; Mouth Diseases; Mouthwashes; Nystatin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Ulcer; Whole-Body Irradiation

Nystatin has been formulated in the form of a flavored pastille (troche) as an alternative to the oral suspension. This parallel, double-blind, randomized, placebo-controlled study evaluated the acceptance and effectiveness of the nystatin pastille at two different dosages. Twenty-four subjects were selected on the basis of clinical signs of denture stomatitis and culture isolation of Candida spp. Each subject was randomly assigned to one of three treatment groups (A, 200,000 units; B, 400,000 units; and C, placebo). At entry, 7 days, 14 days, and at 10 days after cessation of treatment, the clinical condition was evaluated and Gram stain smears and imprint cultures were made and analyzed. The flavored pastille was well accepted by the subjects and both dosages were shown to be effective in significantly reducing or eliminating the Candida organism during active therapy. Data from the 10-day follow-up, however, demonstrated reinfection with the organism. Thus to resolve the condition, effective therapy must include treatment of the etiologic factors of denture stomatitis along with antimicrobial therapy.

Topics: Candidiasis, Oral; Clinical Trials as Topic; Double-Blind Method; Humans; Nystatin; Random Allocation; Stomatitis; Stomatitis, Denture; Tablets

Topics: Aged; Clinical Trials as Topic; Dental Plaque; Denture Rebasing; Denture, Complete; Female; Humans; Nystatin; Oral Hygiene; Stomatitis; Stomatitis, Denture

A double-blind trial of nystatin, amphotericin B, and a placebo was carried out in fifty-two cases of denture-related candidiasis and/or angular cheilitis. The drugs effected a significant clinical cure, but recurrence of the signs was common after withdrawal of the drugs. Concurrent bacteriologic examination showed few cures and continued presence of Candida albicans during the trial. A specimen from a red palate was examined histologically.

Topics: Amphotericin B; Blood Vessels; Candida albicans; Candidiasis, Oral; Cheilitis; Denture, Complete, Upper; Epithelium; Humans; Nystatin; Palate; Placebos; Stomatitis; Stomatitis, Denture

Oral mucositis (OM) is a common adverse reaction to radiotherapy and chemotherapy in oncology. Its treatment requires oral formulations that enhance therapy compliance, improve administration and ensure drug effectiveness. Solid dosage forms that act by slow dissolution, such as pastilles, are an effective alternative to mouthwashes, for their versatility, ease of administration and extended residence time in the oral cavity. The present work describes the development and stability studies of an innovative formulation of nystatin and lidocaine pastilles for the treatment of oral mucositis. Full pharmaceutical quality testing was carried out, including disintegration and dissolution testing, texture profile analysis, grittiness and an antifungal activity testing. A soft pastille formulation containing 0.25% lidocaine and 78,000 IU nystatin was obtained, presenting suitable pharmaceutical characteristics, as a disintegration time of 17 ± 2 min, dissolution rate and microbiological and physicochemical for 30 days when stored at 2-8 °C under light protection. Palatability was also evaluated, being well accepted by a panel of 38 healthy volunteers. This formulation allows an accurate drug dosing by the prescriber, while enabling the patients to control the retention time of the drugs in the oral cavity and consequently manage their pain treatment.

Topics: Antifungal Agents; Candida albicans; Candidiasis, Oral; Drug Liberation; Hardness; Humans; Lidocaine; Nystatin; Stomatitis; Tablets

Concomitant allergic reactions to multiple drugs are uncommon. We report the case of a 66-year-old woman who presented with concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis. It is notable that one of the reactions was caused by oral nystatin, which generally is not considered to be allergenic due to its poor intestinal absorption. Diagnoses were confirmed on patch testing with histologic examination along with oral challenge testing. We also used challenge testing to rule out cross-reactivity among nystatin and other macrolide drugs, both antifungals and antibiotics.

Topics: Administration, Inhalation; Aged; Antifungal Agents; Budesonide; Candidiasis, Oral; Cough; Dermatitis, Allergic Contact; Female; Glucocorticoids; Humans; Nystatin; Stomatitis

In this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of in vitro studies showed that chitosan and gelatine based gels posses properties that makes them excellent candidates for treatment of oral mucositis. These properties include not only the palliative effects of an occlusive dressing but also the potential for delivering therapeutic compounds with chitosan gels providing drug concentrations above their minimum inhibition concentration and extending the retention time in the oral cavity due to their bioadhesive properties. Chitosan also offers an advantage over suspensions because of its inherent antimicrobial properties. The performance of gelatin-based gels highlights the novel, non-toxic, in situ forming gelatine based hydrogel. The results of in vitro drug release experiments demonstrated that all the hydrogel showed sustained release properties.

Topics: Anti-Bacterial Agents; Antifungal Agents; Chitosan; Drug Delivery Systems; Gelatin; Gels; Nystatin; Stomatitis

Methemoglobinemia is a rare congenital or acquired disease of increased blood methemoglobin concentration. We documented 2 cases of children suffering from neuroblastoma whose postchemotherapy anemia, leucopenia, and stomatitis were complicated by methemoglobinemia after using a formulary oral gel (7.5% benzocaine, doxycycline, nystatin, glycerin). The complication resulted in hospital treatment. Percutaneous oxygen saturation remained at 85% and 87% despite administration of 100% oxygen through a nonrebreather mask. Arterial blood gas analysis showed an oxygen saturation of 98% and 97%, respectively. Spectroscopic measurement showed methemoglobin concentration of 42% and 35.5%, respectively. After red blood cell transfusion and oral ascorbic acid in case 1 and methylene blue in case 2, the patients' condition improved. Although the benzocaine gel is not in use in several medical systems, it should be considered as a possible reason for methemoglobinemia.

Topics: Administration, Topical; Anesthetics, Local; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Benzocaine; Child; Doxycycline; Drug Combinations; Gels; Glycerol; Humans; Infant; Kidney Neoplasms; Male; Methemoglobinemia; Neuroblastoma; Nystatin; Stomatitis; Wilms Tumor

Despite aggressive antifungal prophylaxis, the increased risk for systemic fungal infection in recipients of hematopoietic cell transplants (HCT) continues to be a significant concern because Candida infection can cause morbidity and mortality in these patients. The objectives of this study were to examine the relationship of oral colonization by Candida species to systemic infection, mortality, and the impact of antifungal treatment on a population of recipients of HCT.. One hundred and fifteen consecutive patients undergoing hematopoietic cell transplantation were evaluated. Oral examinations and cultures for Candida were completed before transplantation and on a weekly basis until discharge. The oral complications were assessed, and the level of mucositis was scored by using the National Cancer Institute grade. Systemic antifungal prophylaxis was provided to all patients. Chlorhexidine oral rinses were also routinely provided.. Colonization by Candida species was identified in 31% of patients. Fifty-six percent of patients with colonization had clinical evidence of oral candidiasis. Significantly decreased Candida colonization was seen in patients using chlorhexidine alone compared with those using chlorhexidine and nystatin together (P <.046). Twenty-five patients died in the immediate posttransplantation period, 17 of whom were Candida-positive. The length of hospital stay ranged from 15 to 153 days; increased stay was also associated with Candida colonization (P =.04). Seventy-four percent of all patients developed ulcerative mucositis. More severe mucositis was seen in patients undergoing chemotherapy and radiation therapy. There was no significant difference between Candida colonization and the presence or severity of mucositis.. Despite systemic and topical antifungal prophylaxis, oropharyngeal colonization by Candida species was common in patients who had received HCT. Candidiasis was commonly present in those who did not survive the early transplant period. Of the 25 patients who died early after the transplantation, 92% had ulcerative mucositis in comparison with 70% of those who survived, reflecting the association of oral mucositis with the toxicity of HCT. There was a significant relationship among allogeneic and autologous HCT, length of stay, and colonization of Candida. In patients undergoing systemic antifungal prophylaxis, chlorhexidine rinse was statistically more effective in reducing colonization by Candida than chlorhexidine and nystatin combined (P =.046).

Topics: Adult; Anti-Infective Agents, Local; Antifungal Agents; Candida albicans; Candidiasis, Oral; Cause of Death; Chemoprevention; Chlorhexidine; Female; Gingivitis, Necrotizing Ulcerative; Hematopoietic Stem Cell Transplantation; Humans; Length of Stay; Male; Middle Aged; Mouth; Mouthwashes; Nystatin; Stomatitis; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome

The treatment for pediatric cancer can have serious oral complications that adversely affect prognosis. Dental intervention to pediatric cancer patients is crucial in influencing side effects of therapy. This case study will demonstrate the role for oral intervention prior to and during cancer chemotherapy, as well as demonstrate the overall success achieved with interdisciplinary care.

Topics: Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Bone Marrow Purging; Child, Preschool; Female; Humans; Mouth Diseases; Neuroblastoma; Nystatin; Pain Measurement; Stem Cell Transplantation; Stomatitis; Streptococcus; Toothbrushing; Vancomycin

Therapeutic application of immunoglobulin is reported to be successful in radiation-induced oral and oropharyngeal mucositis. In this study the efficacy of prophylactic application of immunoglobulin was investigated. In 42 patients with head and neck cancer, postoperative radiation treatment or radiation combined with chemotherapy was performed. In 20 consecutive patients, prophylactic mucositis treatment consisted of panthenol (4 x 10 ml/day) and nystatin (4 x 1 ml/day). The 22 following patients received, supplementary to panthenol and nystatin, 800 mg (5 ml) human immunoglobulin intramuscularly once weekly. During the treatment time, the degree of mucositis was examined 3 times a week. The distribution of maximal mucositis degree revealed slightly more severe mucous membrane reaction in the control group compared with the immunoglobulin group (n.s.). The analysis of mean mucositis degrees in both groups demonstrated statistically significant differences (t test, p = 0.031) related to the entire group (n = 42) and to those 16 patients receiving radiation combined with chemotherapy. There was no significant immunoglobulin-induced effect on mucositis in patients treated by radiation alone. The time from the beginning of therapy to the first interruption could be prolonged 5 days in the immunoglobulin group (n.s.). In conclusion, it is demonstrated that the prophylactic application of immunoglobulin seems to lower the degree of radiation-induced mucositis. In comparison to the published data about therapeutically given immunoglobulin, the clinical efficacy of the prophylactic application of immunoglobulin as it is performed in this study is less evident.

Topics: Adult; Aged; Anti-Bacterial Agents; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Immunization, Passive; Immunoglobulins; Injections, Intramuscular; Laryngeal Neoplasms; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Mouthwashes; Nystatin; Oropharynx; Pantothenic Acid; Pharyngeal Neoplasms; Pharyngitis; Radiation Injuries; Radiotherapy; Stomatitis

Antibody-dependent cellular cytotoxicity (ADCC) and lymphocyte-induced angiogenesis (LIA) of mononuclear leucocytes (MNC) isolated from the peripheral blood of patients with denture stomatitis mycotic were examined. The obtained results have shown a decrease in ADCC in patients with mycotic infection of oral cavity. Similarly, the ability to induce angiogenesis by MNC isolated from these patients was decreased in comparison with angiogenesis induced by control MNC. After the anti-mycotic treatment, an increase in ADCC and LIA was noted.

Topics: Animals; Candidiasis, Oral; Cytotoxicity Tests, Immunologic; Humans; Immunity, Cellular; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Middle Aged; Neovascularization, Pathologic; Nystatin; Polyenes; Stomatitis; Stomatitis, Denture

Infection of the oral mucous membrane is frequent in patients with removable prostheses, either totally of partially, and particularly when the prostheses is palatal. The principal etiological factor causing the infection is accepted to be "Candidas" aided by the presence of plaque bacteria (in patients with poor oral hygiene care), and a poor fit of the prostheses to the soft tissues. Treatment of the infection must proceed in the following order: a) use of effective medication against oral fungus such as Nystatin or Ketoconazole. b) Meticulous oral hygiene care in the mucous membrane as well as in the prostheses, but using the prostheses as little as possible during the treatment period. c) A total cure of the infection (denture stomatitis) before proceeding to the next phase of the treatment. d) Determination of the adjustment and occlusion of the prostheses in order to determine those areas of the prostheses which need to be refilled because of maladjustment of the prostheses to the soft tissues of the patient.

Topics: Candidiasis, Oral; Chlorhexidine; Denture, Complete; Humans; Ketoconazole; Nystatin; Oral Hygiene; Stomatitis; Stomatitis, Denture

Topics: Adult; Aged; Candida albicans; Candidiasis, Oral; Chlorhexidine; Denture, Complete; Disinfection; Female; Humans; Male; Middle Aged; Mouth; Mouthwashes; Nystatin; Stomatitis; Stomatitis, Denture

Topics: Adult; Aged; Atrophy; Candida albicans; Candidiasis, Oral; Cheilitis; Chronic Disease; Denture, Complete, Upper; Drug Resistance, Microbial; Female; Humans; Male; Middle Aged; Nystatin; Stomatitis; Stomatitis, Denture; Tablets

Topics: Antineoplastic Agents; Child; Drug Combinations; Humans; Lidocaine; Neomycin; Nystatin; Stomatitis

Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Mouth; Natamycin; Nystatin; Stomatitis; Stomatitis, Denture; Time Factors

Topics: Candidiasis, Oral; Chlorhexidine; Dental Plaque; Denture, Complete; Humans; Nystatin; Stomatitis; Stomatitis, Denture

A 14-day old infant with stomatitis due to Candida albicans presented with frequent emesis and was found to have esophagitis by barium esophagram. She responded promptly to oral Mycostatin suspension: her emesis subsided and the stomatitis resolved. Repeat esophagram on the seventh day of therapy showed complete resolution of the esophageal mucosal abnormalities. Although Candida stomatitis is common in infants, the incidence and appropriate therapy of Candida esophagitis as a complication in otherwise normal infants are unknown. This patient responded well to frequent therapy with an oral, nonabsorbable antifungal agent.

Topics: Candidiasis; Esophagitis; Female; Humans; Infant, Newborn; Nystatin; Stomatitis

Topics: Candidiasis, Oral; Humans; Miconazole; Nystatin; Stomatitis

The effect of nystatin treatment on denture stomatitis subclassified as generalized simple inflammation and inflammatory papillary hyperplasia has been studied. Twenty-four patients were carefully instructed to apply a thin layer of nystatin dusting powder on the fitting surface of the maxillary denture three times a day for 14 d. Different parameters were studied on three occasions; at the beginning of experiment and after 14 and 28 d. An untreated group of 24 patients with the same types of denture stomatitis served as control. The effect of treatment was evaluated by changes in the clinical erythema, the yeast colonization obtained by mycologic sampling on the palatal mucosa and on the denture base, and changes in the histologic picture of the mucosa obtained by biopsy. Subepithelial inflammation, leukocyte penetration, edema and thickness of the epithelium were histologic parameters. After 14 d of treatment the experimental group compared with the control group showed a statistically significant decrease in palatal erythema and in the amount of yeast colonies. No significant changes were found microscopically. Twenty-eight days after start, i.e. 14 d after withdrawal of the nystatin, there still was a statistically significant improvement of the palatal erythema in the experimental group compared with the controls. However, no patient was totally cured. There were no significant changes in the number of yeast colonies and the histologic parameters.

Topics: Aged; Denture, Complete; Female; Humans; Male; Middle Aged; Nystatin; Palate; Stomatitis; Stomatitis, Denture; Yeasts

The therapy of denture sore mouth which is induced by Candida albicans must take its bearings about the general and local disposition factors. The crucial points of stomatological treatment are pointed to. The problems related to local antimycotic therapy in the oral cavity are discussed. A new antimycotic dosage form, the nystatin-gelatin foil, for local application in denture wearers in presented. Its dosage and its use are described.

Topics: Administration, Topical; Bandages; Candidiasis, Oral; Gelatin; Humans; Nystatin; Stomatitis; Stomatitis, Denture

The authors describe the formula and the manufacture of nystatin-gelatin foils that are a new dosage form for local application in case of denture sore mouth induced by Candida albicans. It is pointed to the requirements that a pharmaceutically used gelatin should meet. Furthermore, the authors discuss biopharmaceutical aspects of the nystatin-gelatin foil.

Topics: Candidiasis, Oral; Citrates; Drug Compounding; Gelatin; Humans; Nystatin; Stomatitis; Stomatitis, Denture

Seventy-four patients wearing full upper and lower dentures were examined in the study; 37 exhibited varying degrees of denture sore mouth (DSM) while the remaining 37 patients acted as controls. Denture trauma was more common in the DSM group. Candida was grown from 73 per cent of patients with DSM but only from 22 per cent of controls. Control patients had better denture hygiene than DSM patients. One year later 22 of the original DSM patients wearing newly made dentures were re-examined. Nine out of 22 still exhibited varying degrees of DSM. In the 9 cases persisting, a nystatin-chlorhexidine treatment plan was prescribed, resulting in resolution of 7 further cases. The cases that failed resolve were wearing unstable traumatogenic new dentures.

Topics: Aged; Candida; Candidiasis, Oral; Chlorhexidine; Dental Occlusion, Traumatic; Denture Retention; Denture, Complete, Upper; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nystatin; Oral Hygiene; Stomatitis; Stomatitis, Denture

Uremia is defined as the accumulation of nitrogenous waste products in the blood. Uremia may be caused by either acute or chronic renal failure. Uremic stomatitis represents a relatively uncommon intraoral complication of uremia. Uremic stomatitis has classically been divided into ulcerative and nonulcerative types. Reported here is a patient with chronic renal failure exhibiting intraoral lesions that persisted despite local treatment but rapidly cleared following renal dialysis. This case represents the first published report of the microscopic appearance of the nonulcerative type and presents unusual tissue changes heretofore unreported.

Topics: Adult; Biopsy; Candidiasis, Oral; Coloring Agents; Diagnosis, Differential; Dihydroxyphenylalanine; Humans; Hydrogen Peroxide; Male; Mycoses; Nystatin; Renal Dialysis; Stomatitis; Tetracycline; Uremia

Recurrent nonspecific stomatitis may be an oral sign of pernicious anemia. Repeated examinations and blood studies are important when the cause of stomatitis is not clear on initial evaluation of a complaint of sore mouth. Three cases of pernicious anemia are presented to illustrate the similarities and differences in oral signs of pernicious anemia.

Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Candida albicans; Candidiasis, Oral; Female; Glossitis; Humans; Male; Middle Aged; Nystatin; Stomatitis; Vitamin B 12

Topics: Dosage Forms; Gelatin; Glycerol; Humans; Nystatin; Oxytetracycline; Prednisone; Reagent Strips; Stomatitis

Topics: Antibodies; Bacteria; Dentures; Epithelial Cells; Epithelium; Fungi; Humans; Microscopy, Electron, Scanning; Mouth; Nystatin; Palate; Penicillins; Pressure; Stomatitis; Stomatitis, Denture; Streptococcus; Streptococcus pneumoniae

Topics: Candida; Candidiasis, Oral; Denture Liners; Humans; Nystatin; Stomatitis; Stomatitis, Denture

Topics: Amphotericin B; Candidiasis, Oral; Dentures; Humans; Nystatin; Stomatitis

Topics: Adult; Aged; Burning Mouth Syndrome; Candidiasis, Oral; Dental Occlusion, Balanced; Denture, Complete; Female; Humans; Male; Middle Aged; Nystatin; Stomatitis; Tissue Conditioning, Dental

Topics: Acrylic Resins; Adult; Aged; Anti-Bacterial Agents; Candidiasis, Oral; Chromium Alloys; Cytodiagnosis; Denture, Complete; Denture, Partial, Removable; Drug Resistance, Microbial; Female; Humans; Hypersensitivity; Male; Middle Aged; Nystatin; Palate; Stomatitis; Tissue Conditioning, Dental

Topics: Candida; Dermatomycoses; Eczema; Female; Genitalia; Germany, East; Humans; Male; Mouth Mucosa; Mucous Membrane; Nystatin; Skin; Skin Diseases; Skin Ulcer; Stomatitis; Yeasts

Topics: Candidiasis, Oral; Dentistry; Nystatin; Stomatitis

Topics: Aged; Candida; Candidiasis, Oral; Cheilitis; Denture Bases; Denture Retention; Denture, Complete, Upper; Female; Humans; Inflammation; Male; Middle Aged; Mouth; Mouth Mucosa; Nystatin; Oral Health; Saliva; Stomatitis; Vertical Dimension; Vitamin B Deficiency

Topics: Candidiasis; Candidiasis, Oral; Cheilitis; Denture, Complete; Dentures; Drug Therapy; Glossitis; Humans; Nystatin; Stomatitis