nystatin-a1 and Stomach-Ulcer

The effects of aqueous and alkaline extracts from Agaricus blazei Murill, an edible mushroom used as folk medicine in Brazil, Japan, and China to treat several illnesses, were investigated on the basis of the inflammatory process induced by different agents. Oral administration of A. blazei extracts marginally inhibited the edema induced by nystatin. In contrast, when complete Freund's adjuvant was used as the inflammatory stimulus, both extracts were able to inhibit this process significantly (P < .05, analysis of variance followed by Tukey-Kramer multiple comparison post hoc test), although it inhibited the granulomatous tissue induction moderately. These extracts were able to decrease the ulcer wounds induced by stress. Also, administration of extracts inhibited neutrophil migration to the exudates present in the peritoneal cavity after carrageenin injection. Therefore, it is possible that A. blazei extracts can be useful in inflammatory diseases because of activation of the immune system and its cells induced by the presence of polysaccharides such as beta-glucans.

Topics: Adjuvants, Immunologic; Agaricus; Analysis of Variance; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Arthritis; Carrageenan; Disease Models, Animal; Edema; Freund's Adjuvant; Granuloma; Male; Neutrophil Infiltration; Nystatin; Plant Extracts; Rats; Rats, Wistar; Stomach Ulcer

Topics: Aged; Candidiasis; Humans; Male; Nystatin; Stomach Ulcer

In seven elderly patients with benign gastric ulcer, numerous spores and mycelia of Candida were found in the inflammatory exudate and in the base of the ulcer. All patients were treated with cimetidine and antacids. In five patients the ulcer failed to heal. Cimetidine was replaced with mycostatin and after four weeks of treatment, the ulcers healed completely in four patients. It is assumed that in the elderly, due to the weakening of the host defense mechanisms, Candida may invade the base of the ulcer and disturb the normal process of healing.

Topics: Aged; Candidiasis; Cimetidine; Female; Humans; Male; Middle Aged; Nystatin; Stomach Diseases; Stomach Ulcer

In a 20-month period, generalized chronic cutaneous candidiasis developed in 3 performing bottle-nosed dolphins kept in an indoor pool. Extensive esophagogastric ulcerations were observed in 2 of the dolphins, each of which died, presumably because of these lesions. The 3rd dolphin died during a surgical procedure and did not have any esophagogastric ulcerations. Candida albicans was the only organism isolated from skin lesions but was not isolated from adjacent normal skin of dolphins. Treatment with antifungal drugs was unsuccessful. Subsequently, immunopotentiating treatment with levamisole phosphate resulted in formation of granulation tissue and healing of the skin lesions.

Topics: Animals; Animals, Zoo; Candidiasis, Cutaneous; Dolphins; Esophageal Diseases; Esophagus; Female; Levamisole; Male; Nystatin; Skin; Stomach; Stomach Ulcer; Ulcer