nystatin-a1 and Respiratory-Insufficiency

To determine clinical variables to distinguish invasive pulmonary aspergillosis (IPA) from colonization in patients with chronic pneumopathies with positive culture of Aspergillus spp. in respiratory samples.. Retrospective cohort study including patients with respiratory isolations of Aspergillus spp. during a period of 10 years. IPA was evaluated according to the Bulpa criteria. Clinical variables were collected and a multiple logistic regression analysis was carried out.. Eighty-three patients with isolation of Aspergillus spp. from respiratory samples were included; 68.7% (n=57) of the patients had chronic obstructive pulmonary disease, 18% (n=15) pulmonary fibrosis and 13.3% (n=11) bronchial asthma. Twenty-two patients (26.6%) had IPA. The use of fluconazole (OR 4.49; CI 95% 1.5-13.4; P=.007), severe respiratory failure (OR 4.64; CI 95% 1.46-14.72; P=.009) and hospitalization time (OR 1.05; CI 95% 1.01-1.1; P=.006) were associated with IPA.. Prior use of fluconazole, severe respiratory failure and hospitalization time are associated with IPA in patients with chronic pneumopathies with respiratory isolation of Aspergillus spp.

Topics: Aged; Aged, 80 and over; Antifungal Agents; Aspergillus; Asthma; Bacterial Infections; Carrier State; Chronic Disease; Comorbidity; Cross Infection; Diagnosis, Differential; Disease Susceptibility; Female; Fluconazole; Hospitals, University; Humans; Incidence; Invasive Pulmonary Aspergillosis; Length of Stay; Lung; Lung Diseases; Male; Middle Aged; Nystatin; Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis; Respiratory Insufficiency; Retrospective Studies; Risk Factors; Spain