nystatin-a1 and Respiratory-Distress-Syndrome--Newborn

We describe congenital cutaneous candidiasis (CCC) in a term newborn. The mother had candidal vaginitis 1 week before delivery. At birth, the infant had a generalized, intensely erythematous, papulovesicular eruption, respiratory distress and elevation of liver function tests. The child responded well to intravenous amphotericin B plus topical and oral nystatin. There have been 13 previously reported cases of CCC in infants weighing more than 1500 gm who had evidence of systemic infection. Two deaths were attributed to candidal pneumonia and sepsis. The majority of infants with CCC have infection localized to the skin, but if there is any evidence of respiratory distress or signs of sepsis the possibility of systemic candidiasis and the need for parenteral antifungal therapy must be considered.

Topics: Amphotericin B; Antifungal Agents; Candidiasis; Candidiasis, Cutaneous; Candidiasis, Vulvovaginal; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Liver Function Tests; Nystatin; Pregnancy; Pregnancy Complications, Infectious; Respiratory Distress Syndrome, Newborn