nystatin-a1 and Remission--Spontaneous

113 patients being treated for acute non-lymphoblastic leukaemia were investigated to determine the effect of suppression of body microbial flora on prevention of infection. They were randomly allocated to a control group or a group which received non-absorbed antibiotics by mouth and topical applications of cutaneous and mucosal antiseptic preparations. The group receiving oral non-absorbed antibiotics had significantly few infections, fewer deaths from infection, fewer pyrexial episodes, and consequently received less systemic antibiotic therapy than the controls.

Topics: Acute Disease; Administration, Oral; Administration, Topical; Adolescent; Adult; Antineoplastic Agents; Bacterial Infections; Bacteroides Infections; Chlorhexidine; Colistin; Drug Combinations; Enterobacteriaceae Infections; Framycetin; Humans; Leukemia; Nystatin; Remission, Spontaneous; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections

Monistat Cream (miconazole nitrate 2%), a new fungicidal agent indicated for the treatment of vulvovaginal candidiasis, was evaluated in a comparative study with nystatin vaginal tablets (100,-000 units each). A total of 95 pregnant and non-pregnant patients were treated. Miconazole nitrate was administered once daily, at bedtime, for 14 days to 55 pregnant and non-pregnant patients. Overall, 74.5% (41 of 55 patients) were cured with one course of therapy. In contrast, of 40 nystatin-treated patients (both pregnant and non-pregnant) treated twice daily for 15 days, 22 patients (57.8%) were cured with one course of therapy. This difference in cure rates was statistically significant. Side effects were minimal and comparable in the two treatment groups. No recorded instances of birth defects were observed in infants born to mothers in either treatment group. Monistate Cream, in this study, was found to be a safe and effective drug in treating both pregnant and nonpregnant patients with confirmed candidiasis.

Topics: Adolescent; Adult; Candidiasis, Vulvovaginal; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Imidazoles; Miconazole; Middle Aged; Nystatin; Ointments; Pregnancy; Pregnancy Complications, Infectious; Remission, Spontaneous; Suppositories

Reverse isolation and prophylactic oral nonabsorbable antibiotics were evaluated among 64 consecutive noninfected adults with acute nonlymphocytic leukemia admitted for remission induction. Patients were randomly allocated to laminar air flow room reverse isolation with oral nonabsorbable antibiotics (LAF plus A), routine hospital ward care with antibiotics (W plus A), or ward care alone (W). The LAF plus A patients had a significantly decreased incidence of total infection, bacteremias, pneumonias, rectal abscesses, urinary tract infection, and pharyngitis. Infectious deaths were reduced in the LAF plus A group and the time to the first infection or to fatal infection was delayed. The W plus A patients who regularly ingested the antibiotics had a reduction in infections similar to that of the LAF plus A patients but those who could not tolerate the antibiotics had an incidence of infection comparable to the ward patients. The LAF plus A and the W plus A patients also had higher complete remission rates and longer median survival than the unprotected ward patients.

Topics: Acute Disease; Administration, Oral; Adult; Aged; Air Conditioning; Air Microbiology; Anti-Bacterial Agents; Bacterial Infections; Cross Infection; Environment, Controlled; Female; Gentamicins; Hospital Units; Humans; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Male; Middle Aged; Nystatin; Patient Isolators; Remission, Spontaneous; Urinary Tract Infections; Vancomycin; Ventilation; Virus Diseases

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Gentamicins; Hemorrhage; Humans; Infection Control; Leukemia, Myeloid, Acute; Middle Aged; Nystatin; Patient Isolators; Prospective Studies; Pseudomonas Infections; Remission, Spontaneous; Respiratory Tract Infections; Vancomycin

Topics: Acute Disease; Anti-Bacterial Agents; Bacitracin; Blood Cell Count; Blood Platelets; Disinfection; Drug Combinations; Fever; Germ-Free Life; Glucose; Hexetidine; Humans; Leukemia; Neomycin; Neutropenia; Nystatin; Patient Isolators; Pneumonia; Remission, Spontaneous; Respiratory Tract Infections; Sterilization; Thrombelastography; Time Factors; Xylose

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Feces; Female; Gentamicins; Humans; Leukemia; Male; Middle Aged; Mycoses; Neutrophils; Nystatin; Remission, Spontaneous; Vancomycin

Topics: Adult; Amphotericin B; Aspergillosis; Cytarabine; Female; Humans; Leukemia, Myeloid; Lung Diseases, Fungal; Nystatin; Pulmonary Embolism; Remission, Spontaneous