nystatin-a1 and Pneumonia

Pipemidic acid (PPA) and colistin sodium methanesulfonate (CLM) may selectively suppress aerobic gram-negative bacilli. Twenty-nine patients with acute leukemia were randomized after each course of consolidation chemotherapy to receive a single agent of nystatin (NYS) (34 courses) versus a combination of NYS, PPA and CLM (36 courses). The duration of fever over 39 degrees C was longer with the three drug combination (4.6 +/- 5.1 days) than with NYS alone (1.8 +/- 1.8 days) (P less than 0.01). Four cases of pneumonia occurred and four patients including one having pneumonia died of infection with the three drug combination, while no pneumonia or death occurred with NYS alone (P = 0.06 and P = 0.06, respectively). The combination of NYS, PPA and CLM may be less effective than NYS alone for the prevention of infection in acute leukemia patients with chemotherapy-associated granulocytopenia.

Topics: Acute Disease; Adolescent; Adult; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Colistin; Drug Therapy, Combination; Gram-Negative Bacteria; Humans; Leukemia; Middle Aged; Nicotinic Acids; Nystatin; Pipemidic Acid; Pneumonia; Random Allocation

Topics: Acute Disease; Anti-Bacterial Agents; Bacitracin; Blood Cell Count; Blood Platelets; Disinfection; Drug Combinations; Fever; Germ-Free Life; Glucose; Hexetidine; Humans; Leukemia; Neomycin; Neutropenia; Nystatin; Patient Isolators; Pneumonia; Remission, Spontaneous; Respiratory Tract Infections; Sterilization; Thrombelastography; Time Factors; Xylose

Fungal pneumonia is considered as one of the most serious forms of pneumonia, the number of which has recently increased despite the use of new antimycotic drugs in pulmonology. Specificity of pathogens and torpid current of pneumomycosis represent great difficulties for accurate diagnosis and delay the timely onset of therapy, exacerbating inflammatory changes. In this article we present a rare case of isolated infection of the lungs parenchyma with Candida albicans in the form of focal pneumonia of the right lung lower lobe complicated by a clotted pleurisy. Patient is eighteen-year-old young man who is currently finding in the army. Our attention was attracted the fact that he was hospitalized twice within the 4 months with the same diagnosis - fungal pneumonia. At the same time, the localization of the process was the same as in the previous hospitalization. In this article, we tried to understand the reasons of unsuccessful treatment of this pathology. And we came to the following conclusions that the reason of repeated hospitalization of this patient was the short stay in the hospital and the duration of the diagnostic tests. Bacteriological examination of sputum takes about 5-7 days on average, which led to untimely started treatment. A short period of hospitalization, regulated by the protocols of diagnosis and treatment, contributed to inadequate treatment of this pathology. Thus, today there is a definite demand for the development of rapid diagnostic tests of fungal pneumonia and new protocols for diagnosis and treatment, taking into account the duration of treatment for Candida infection.

Topics: Adolescent; Antifungal Agents; Candida albicans; Candidiasis; Delayed Diagnosis; Fluconazole; Humans; Kazakhstan; Male; Nystatin; Patient Readmission; Pneumonia; Practice Guidelines as Topic

An oral prophylactic antibiotic regimen (neomycin-erythromycin-nystatin) aimed at suppression of the bowel flora was utilized in 20 patients with thermal injury treated in a laminar flow burn unit with strict sterile technique and reverse isolation. The regimen was utilized for an average of 24 days. Surface cultures were obtained twice weekly from multiple areas of the burn wound, and burn wound biopsies were performed one to two times weekly. These patients were compared prospectively with a group of 10 patients treated in otherwise identical fashion, save for the omission of the antibiotic suppressive regimen. Bacterial colonization of the burn wound occurred an average of 19 days after admission in the group receiving antibiotics compared to 4 days after admission in the control group (p less than 0.01). Positive burn biopsies (more than 10(5) bacteria per gm of tissue) were observed twice as often in the group not receiving antibiotics (p less than 0.16) as were infectious complications of several types: bacteremia, burn wound sepsis, urinary tract infections, pneumonitis, cellulitis (0.10 less than p less than 0.20). Staphylococcal or fungal overgrowth were not encountered in the patients receiving prophylactic antibiotics, nor was there an adverse effect on serum creatinine levels with the prolonged use of neomycin.

Topics: Adolescent; Adult; Anti-Bacterial Agents; Bacterial Infections; Burns; Cellulitis; Child; Child, Preschool; Erythromycin; Escherichia coli; Humans; Intestines; Middle Aged; Neomycin; Nystatin; Pneumonia; Prospective Studies; Sepsis; Staphylococcus aureus; Urinary Tract Infections

Topics: Acute Disease; Aminophylline; Anti-Bacterial Agents; Blood Coagulation; Body Temperature; Chronic Disease; Erythromycin; Furosemide; Heparin; Humans; Nikethamide; Nystatin; Oleandomycin; Penicillins; Peptide Hydrolases; Physical Therapy Modalities; Plasma Substitutes; Pneumonia; Pneumonia, Staphylococcal; Streptomycin; Strophanthins; Sulfadimethoxine; Sulfanilamides; Tetracycline; Vitamins

Topics: Aged; Ampicillin; Chronic Disease; Drug Synergism; Haemophilus influenzae; Humans; Lung Diseases, Obstructive; Male; Nystatin; Pneumonia; Sputum; Sulfonamides; Tetracycline; Trimethoprim

Topics: Adult; Aged; Anti-Bacterial Agents; Chloramphenicol; Dysentery, Bacillary; Enterocolitis, Pseudomembranous; Erythromycin; Humans; Intestines; Male; Middle Aged; Nalidixic Acid; Nystatin; Penicillins; Pneumonia; Proteus Infections; Rheumatic Heart Disease; Staphylococcal Infections; Streptomycin; Tetracycline

Topics: Aged; Anemia; Anti-Bacterial Agents; Blood Cell Count; Blood Cells; Blood Chemical Analysis; Blood Transfusion; Bone Marrow Cells; Bone Marrow Examination; Chromosome Aberrations; Female; Humans; Karyotyping; Leukopenia; Middle Aged; Nystatin; Pneumonia; Prednisone; Primary Myelofibrosis; Splenectomy; Thrombocytopenia

Topics: Anti-Infective Agents, Local; Antifungal Agents; Asthma; Bronchitis; Candida; Candidiasis; Child; Culture Techniques; Drug Resistance, Microbial; Fibroblasts; HeLa Cells; Humans; Lung Diseases, Fungal; Nystatin; Pneumonia; Quinolines; Respiratory Tract Infections

Topics: Fungi; Geotrichosis; Humans; Lung Diseases, Fungal; Nystatin; Pneumonia; Pneumonia, Viral

Topics: Anti-Bacterial Agents; Candidiasis; Candidiasis, Oral; Deglutition Disorders; Diagnosis; Esophagitis; Humans; Nystatin; Pneumonia; Prednisolone; Radiography; Sulfonamides; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Nystatin; Phosphates; Pneumonia; Respiratory Tract Infections; Tetracycline

Topics: Adenoviridae; Adenoviridae Infections; Chloramphenicol; Humans; Inclusion Bodies; Infant; Infant Mortality; Nystatin; Pathology; Penicillins; Pneumonia; Pneumonia, Viral; Streptomycin

Topics: Candidiasis; Geriatrics; Humans; Influenza, Human; Lung Diseases, Fungal; Mycoses; Nystatin; Pneumonia

Topics: Amphotericin B; Candidiasis; Geriatrics; Humans; Lung Diseases, Fungal; Nystatin; Organic Chemicals; Pneumonia; Radiography, Thoracic; Tetracycline

Topics: Aerosols; Animals; Candidiasis; Humans; Influenza, Human; Nystatin; Pneumonia; Rats; Sodium

Topics: Aerosols; Humans; Leydig Cells; Male; Nystatin; Plasma Cells; Pneumonia; Pneumonia, Pneumocystis; Surface-Active Agents

Topics: Aerosols; Anti-Bacterial Agents; Antibiotics, Antitubercular; Candidiasis; Lung Diseases; Nystatin; Pneumonia

Topics: Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Oral; Child; Dermatologic Agents; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Nystatin; Pneumonia; Skin Diseases