nystatin-a1 and Otitis-Media

In a retrospective study of patients who had undergone myringoplasty at our department within a 12-month period, we assessed the graft take rate using tri-adcortyl ointment (TAO) as ear dressing. Data including age, site and size of perforation, grade of surgeon, surgical approach, use of postoperative ear dressings, complications and audiometric outcome was collected from the patient notes and analysed. The overall success rate of the operation (with success being defined as an intact tympanic membrane at 6 months) was noted. Seventy-seven patients were operated, but data were complete on 64 patients and these constituted the study population. TAO was used in 95% of the patients and BIPP gauze pack in the remaining 5%. Age ranged from 8 to 63 years (mean 34 years). Mean follow-up period was 13 months. Most of the operations (72.88%) were carried out by consultants with a success rate of 89% and the remaining patients were operated by trainees with a success rate of 88% (P = 1.000). The overall success rate was 89, 90.16% for TAO and 66.66% (2 out of 3) for BIPP (P = 0.298), 95% for small and 86% for subtotal perforations (P = 0.573), 85% for anterior and 100% for posterior perforations (P = 0.240), 91% for adult patients and 88% for children (P = 1.000). TAO is a suitable ear dressing in myringoplasty. Routine use of TAO did not affect the success rate of myringoplasty at our centre.

Topics: Adolescent; Adult; Aged; Audiometry; Child; Drug Combinations; Female; Follow-Up Studies; Gramicidin; Hearing; Humans; Male; Middle Aged; Myringoplasty; Neomycin; Nystatin; Occlusive Dressings; Ointments; Otitis Media; Retrospective Studies; Rupture, Spontaneous; Treatment Outcome; Triamcinolone Acetonide; Tympanic Membrane Perforation

Topics: Anti-Bacterial Agents; Candidiasis; Humans; Infant; Male; Nystatin; Otitis Media; Recurrence

We compared the clinical efficacy of Auricularum to its bacteriological efficacy in 36 patients with a chronic middle ear disease. The clinical study confirms the very good efficacy of Auricularum with an improvement rate equal to 81% and 69.4% of "very good" results. The bacteriological study confirms the usual sensitivity of gram-negative bacilli (except the Proteus) to polymyxine B, the sensitivity of gram-positive germs to tetracycline for 60% of them and the sensitivity of fungus (isolated only once) to nystatine. Moreover, the bacteriological study shows that Auricularum with a concentration more or equal to 0.1 ml inhibits every germ, including the well-known resistant germs. This concentration of 0.1 ml corresponds to 2 drops of the drug in suspension and is less than the recommended dosage. This finding proves the very good efficacy of Auricularum in chronic middle ear diseases, including the ones due to usual resistant germs to the two antibiotics (polymyxine B and oxytetracycline) enclosed in the drug composition.

Topics: Bacteriological Techniques; Chronic Disease; Dexamethasone; Drug Combinations; Humans; Microbial Sensitivity Tests; Nystatin; Otitis Media; Oxytetracycline; Polymyxin B; Polymyxins

Topics: Candidiasis, Oral; Child, Preschool; Humans; Male; Nystatin; Otitis Media

Topics: Amphotericin B; Ampicillin; Anti-Bacterial Agents; Aspirin; Cephalexin; Drug Prescriptions; Erythromycin; Haemophilus influenzae; Humans; Metronidazole; Nystatin; Otitis Media; Penicillins; Pharyngitis; Staphylococcus; Streptococcus pyogenes

Topics: Adenoidectomy; Amphotericin B; Anemia; Anti-Bacterial Agents; Ear, Inner; Hemorrhage; Hydrocarbons; Meningitis; Mycoses; Nystatin; Otitis Media; Otolaryngology; Pediatrics; Pharynx; Streptomycin; Tonsillectomy; Toxicology; Vitamins

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antifungal Agents; Aspergillosis; Biomedical Research; Candidiasis; Humans; Hydrocortisone; Mastoiditis; Mycoses; Nystatin; Otitis Media; Otolaryngology; Penicillium; Postoperative Complications; Surgical Procedures, Operative