nystatin-a1 and Liver-Neoplasms

nystatin-a1 has been researched along with Liver-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for nystatin-a1 and Liver-Neoplasms

ArticleYear
Utility of 6-amino-2-thiouracil as a precursor for the synthesis of bioactive pyrimidine derivatives.
    Bioorganic & medicinal chemistry, 2007, Sep-15, Volume: 15, Issue:18

    The condensation of 6-amino-2-thiouracil 1 with aromatic aldehydes afforded azomethine derivatives 3a,b. The formed azomethines underwent [4+2] cycloaddition with enaminones 4a-c and enaminonitrile 9 to form the corresponding condensed pyrimidines 8a-f and 11a,b, respectively. On the other hand, the interaction of 3a,b with acetylene derivatives 12a,b, 14 afforded the corresponding pyrido[2,3-d]pyrimidines 13a-d and 16a,b, respectively. The newly synthesized 2-azadiene 18 reacted with ortho-aminophenol and ortho-aminothiophenol 19a,b to yield the amidines 21a,b. The in vitro antimicrobial activity of some of the newly synthesized compounds was examined. All the tested compounds proved to be active as antibacterial and antifungal agents. Also the in vivo antitumor activity of compounds 8a, 11b, 13a,d, and 16b against lung (H460) and liver (HEPG2) carcinoma cells was examined. Compounds 8a, 16b showed moderate activity against lung carcinoma cell line (H460).

    Topics: Antifungal Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Liver Neoplasms; Lung Neoplasms; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiouracil; Tumor Cells, Cultured

2007
[The damaging effect of the sodium salt of nystatin on ascitic tumor cells].
    Voprosy onkologii, 1975, Volume: 21, Issue:6

    The experiments in vitro have demonstrated that an application of 0.1 mg/ml of nistatine into ascitic cells suspension would result in swelling of cells and 80% loss of intracellular potassium, associated with a considerable reduction of Na+K+-ATP-ase activity, the intensity of respiration and glycosis being changed but insignificantly. Thus, the influence of a polyene antibiotic - nistatine on the water-salt balance of ascitic cells under study is likely to be somewhat related with inhibition of NA+K+-dependent ATP-ase.

    Topics: Adenosine Triphosphatases; Animals; Antibiotics, Antineoplastic; Ascitic Fluid; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Female; Glycolysis; In Vitro Techniques; Liver Neoplasms; Mice; Neoplasms, Experimental; Nystatin; Ovarian Neoplasms; Oxygen Consumption; Potassium; Sodium

1975