nystatin-a1 and Hypersensitivity

Topics: Candidiasis; Candidiasis, Vulvovaginal; Female; Humans; Hypersensitivity; Nystatin; Research Design; Syndrome

Candida albicans infection has been proposed to cause a chronic hypersensitivity syndrome characterized by fatigue, premenstrual tension, gastrointestinal symptoms, and depression. Long-term antifungal therapy has been advocated as treatment for the syndrome, which is most often diagnosed in women with persistent or recurrent candida vaginitis.. To determine the efficacy of nystatin therapy for presumed candidiasis hypersensitivity syndrome, we conducted a 32-week randomized, double-blind, cross-over study using four different combinations of nystatin or placebo given orally or vaginally in 42 premenopausal women who met present criteria for the syndrome and had a history of candida vaginitis. The outcomes studied were the changes from base line in scores for vaginal, systemic, and overall symptoms and in the results of standardized psychological tests.. The three active-treatment regimens (oral and vaginal nystatin, oral nystatin and vaginal placebo, and oral placebo and vaginal nystatin) and the all-placebo regimen significantly reduced both vaginal and systemic symptoms (P less than 0.001), but nystatin did not reduce the systemic symptoms significantly more than placebo. On average, the scores for systemic symptoms improved 25 percent with the three active-treatment regimens and 23 percent with the all-placebo regimen, a difference of only 2 percent (95 percent confidence interval, -3 to 7 percent). As expected, the three active-treatment regimens were more effective than placebo in relieving vaginal symptoms (P less than 0.001). All four regimens reduced psychological symptoms and global indexes of distress; there were no significant differences among the treatment regimens.. In women with presumed candidiasis hypersensitivity syndrome, nystatin does not reduce systemic or psychological symptoms significantly more than placebo. Consequently, the empirical recommendation of long-term nystatin therapy for such women appears to be unwarranted.

Topics: Administration, Oral; Adult; Candidiasis, Vulvovaginal; Capsules; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypersensitivity; Nystatin; Syndrome

Topics: Antifungal Agents; Candida; Candidiasis; Controlled Clinical Trials as Topic; Gastrointestinal Diseases; Humans; Hypersensitivity; Immunoglobulin E; Nystatin; Reproducibility of Results; Research Design; Syndrome

Topics: Candidiasis; Humans; Hypersensitivity; Nystatin; Syndrome

Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Drug Combinations; Female; Gramicidin; Humans; Hypersensitivity; Male; Middle Aged; Neomycin; Nystatin; Ointments; Skin Diseases; Triamcinolone Acetonide

Topics: Adolescent; Adult; Aged; Allergens; Angioedema; Candida albicans; Candidiasis; Child; Chronic Disease; Desensitization, Immunologic; Female; Humans; Hypersensitivity; Male; Middle Aged; Nystatin; Urticaria

Topics: Acrodermatitis; Adult; Candidiasis, Cutaneous; Chronic Disease; Humans; Hypersensitivity; Male; Middle Aged; Nystatin

Topics: Adult; Amphotericin B; Antigens; Candida; Candidiasis; Chronic Disease; Female; Food Hypersensitivity; Humans; Hypersensitivity; Immunoglobulin E; Male; Nystatin; Saccharomyces; Skin Tests; Urticaria

Topics: Actinomycosis; Africa; Amphotericin B; Aspergillosis; Blastomycosis; Candidiasis; Coccidioidomycosis; Farmer's Lung; France; Histoplasmosis; Humans; Hypersensitivity; Lung Diseases, Fungal; Nystatin; Sputum; United States

Topics: Acrylic Resins; Adult; Aged; Anti-Bacterial Agents; Candidiasis, Oral; Chromium Alloys; Cytodiagnosis; Denture, Complete; Denture, Partial, Removable; Drug Resistance, Microbial; Female; Humans; Hypersensitivity; Male; Middle Aged; Nystatin; Palate; Stomatitis; Tissue Conditioning, Dental

Topics: Aspergillosis; Humans; Hypersensitivity; Immunoelectrophoresis; Lung Diseases, Fungal; Male; Middle Aged; Nystatin

Topics: Candidiasis; Humans; Hypersensitivity; Nystatin; Tetracycline

Topics: Candida albicans; Candidiasis; Drug Therapy; Erythema; Humans; Hypersensitivity; Hypersensitivity, Delayed; Nystatin; Skin Diseases, Genetic

Topics: Anaphylaxis; Anti-Bacterial Agents; Chloramphenicol; Colistin; Diagnosis; Drug Hypersensitivity; Humans; Hypersensitivity; Nystatin; Penicillins; Statistics as Topic; Streptomycin; Tetracycline; Toxicology

Topics: Amphotericin B; Candida; Candida albicans; Candidiasis; Candidiasis, Cutaneous; Desensitization, Immunologic; Gentian Violet; Humans; Hypersensitivity; Nystatin

Topics: Anti-Bacterial Agents; Fungi; Griseofulvin; Hypersensitivity; Mycoses; Nystatin