nystatin-a1 and Esophageal-Diseases

High-intensity impulse laser radiation proved effective in 23 patients with esophageal candidiasis. The highest effect was achieved in its use with nistatin. In low laser efficacy radiation should be combined with transendoscopic administration of granulocytes concentrate. This produced clinico-endoscopic remission in 98.3% of the cases.

Topics: Adult; Antifungal Agents; Candidiasis; Combined Modality Therapy; Deglutition Disorders; Esophageal Diseases; Esophagoscopy; Evaluation Studies as Topic; Female; Humans; Laser Therapy; Male; Nystatin

Topics: Adolescent; Candidiasis; Diagnosis, Differential; Esophageal Achalasia; Esophageal Diseases; Esophagoscopy; Humans; Male; Nystatin

In a patient with chronic esophageal candidiasis due to C. tropicalis that was refractory to mycostatin and ketoconazole, a generalized cell-mediated immunodeficiency state was detected. Samples of plasma from this patient inhibited T-lymphocyte function, suppressing both rosette formation and mitogen responsiveness of T-cells derived from the patient and from normal individuals. Following plasma exchange, the patient's immune defect resolved and her candida infection disappeared. On further analysis, the plasma inhibitory factor was found to be of low molecular weight (less than 10,000) and heat labile. Preliminary studies suggested that this inhibitor was candida-derived, since it was removed from plasma by anti-candida antibodies in solid phase. Immunodeficiency in chronic candidiasis may be improved by removal of circulating inhibitory factors through plasma exchange.

Topics: Adult; Candidiasis; Esophageal Diseases; Female; Humans; Immunologic Deficiency Syndromes; Interleukin-2; Ketoconazole; Lymphokines; Molecular Weight; Nystatin; Rosette Formation; T-Lymphocytes

In 14 patients with candida infection of the oesophagus, the clinical, radiologic and endoscopic findings are described. It is pointed out that candida mycosis of the oesophagus may occur primarily and without underlying disease. The authors report on the therapy of candidiasis.

Topics: Adult; Aged; Candidiasis; Esophageal Diseases; Esophagoscopy; Female; Humans; Male; Middle Aged; Nystatin

Gastrointestinal Candida infection is more prevalent than previously recognized. It is most often seen in patients with underlying impairment of the immune system but may also occur in apparently normal individuals. Esophageal involvement is most common, presenting with odynophagia, dysphagia, or bleeding. Gastric Candida infection may cause diffuse mucosal involvement or focal invasion of benign gastric ulcers. Intestinal candidiasis is uncommon and poorly characterized. The diagnosis is usually established by visualizing the characteristic yeast or mycelial forms in endoscopic brushings and biopsies. Oral nystatin is effective therapy in many patients, but other antifungal agents may be needed in extensive or persistent disease, especially in immunocompromised patients.

Topics: Candidiasis; Deglutition Disorders; Diagnosis, Differential; Esophageal Diseases; Flucytosine; Humans; Imidazoles; Intestinal Diseases; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Nystatin; Polyenes; Stomach Diseases

Topics: Adult; Aged; Candidiasis; Esophageal Diseases; Esophagoscopy; Esophagus; Female; Humans; Male; Middle Aged; Nystatin

Chronic candidiasis of the oral cavity and esophagus may present with a varying clinical picture. Three cases of this entity are presented. Infection occurs when the ecologic balance of normal flora and local factors are upset. Predisposing factors are listed. The different presentations, methods of evaluation, diagnosis, treatment alternatives, and immunologic applications are discussed. The problems of the chronic form of the disease, with it becoming deeply ingrained and recurrent, are stressed.

Topics: Candidiasis, Oral; Chronic Disease; Esophageal Diseases; Female; Humans; Middle Aged; Nystatin

The case of a 38-year-old male patient with chronic recurrent oropharyngo-esophageal candidiasis since early childhood, resistant to topical therapy with nystatin, is reported. The disease had resulted in impressive oropharyngeal lesions and stricturing of the midesophagus. Extensive in vivo and in vitro immunological studies done before and after successful treatment with miconazole showed a persistent partial deficiency of the cell-mediated immune system, in particular that directed toward candida antigens. Miconazole, a new potent antifungal drug, proved effective in controlling the candidiasis, which had become resistant to conventional treatment.

Topics: Adult; Candidiasis; Candidiasis, Oral; Drug Resistance, Microbial; Esophageal Diseases; Humans; Imidazoles; Immunity, Cellular; Immunologic Deficiency Syndromes; Male; Miconazole; Nystatin; Pharyngeal Diseases

In a 20-month period, generalized chronic cutaneous candidiasis developed in 3 performing bottle-nosed dolphins kept in an indoor pool. Extensive esophagogastric ulcerations were observed in 2 of the dolphins, each of which died, presumably because of these lesions. The 3rd dolphin died during a surgical procedure and did not have any esophagogastric ulcerations. Candida albicans was the only organism isolated from skin lesions but was not isolated from adjacent normal skin of dolphins. Treatment with antifungal drugs was unsuccessful. Subsequently, immunopotentiating treatment with levamisole phosphate resulted in formation of granulation tissue and healing of the skin lesions.

Topics: Animals; Animals, Zoo; Candidiasis, Cutaneous; Dolphins; Esophageal Diseases; Esophagus; Female; Levamisole; Male; Nystatin; Skin; Stomach; Stomach Ulcer; Ulcer

Topics: Adult; Amphotericin B; Candidiasis; Candidiasis, Oral; Esophageal Diseases; Fluoroscopy; Humans; Leukemia; Leukemia, Myeloid; Male; Middle Aged; Nystatin

Topics: Amphotericin B; Antifungal Agents; Candidiasis; Esophageal Diseases; Esophagus; Humans; Nystatin; Radiography

A 35-year-old man with idiopathic hypoparathyroidism and moniliasis developed progressive dysphagia and weight loss. Diagnostic studies established the presence of esophageal moniliasis. Therapy with a viscous suspension of nystatin resulted in rapid clinical improvement; prolonged administration of the drug was associated with progressive widening of a narrowed segment of esophagus and complete disappearance of dysphagia. The chemotherapy of esophageal moniliasis is discussed in the light of current knowledge of the pharmacological action of nystatin.

Topics: Administration, Oral; Adult; Candidiasis; Chronic Disease; Deglutition Disorders; Esophageal Diseases; Esophagus; Humans; Male; Nystatin; Radiography; Suspensions; Viscosity

Topics: Anti-Bacterial Agents; Antineoplastic Agents; Candidiasis; Cobalt Isotopes; Esophageal Diseases; Esophagitis; Esophagoscopy; Glucocorticoids; Humans; Lip Neoplasms; Male; Middle Aged; Nystatin; Pharyngeal Neoplasms; Radiotherapy; Tonsillar Neoplasms

Topics: Adult; Aged; Agranulocytosis; Anti-Bacterial Agents; Candidiasis; Esophageal Diseases; Female; Glucocorticoids; Humans; Male; Middle Aged; Nystatin; Radiography

Topics: Amphotericin B; Candida; Candidiasis; Deglutition Disorders; Diagnosis, Differential; Esophageal Diseases; Female; Humans; Infusions, Parenteral; Middle Aged; Nystatin; Radiography