nystatin-a1 and Ear-Diseases

Fungi, in comparison with other pathogenic factors, have high pathogenicity. The number of fungal species which are able to infect people is over 500. The upper respiratory tract and ear have permanent contact with external environment which makes their ontocenoses open to continuous exchange of microorganisms of which they consist. In etiology of inflammatory processes 21 species which belonging to 3 genera (Zygomycota, Ascomycota, Basidiomycota) of fungi play important role. Administration of antifungal drugs can be: prophylactic, empiric preemptive and therapeutic. Physicians may prescribe antibiotics (mainly pollens: amphotericin B, natamycin and nystatin) and chemiotherapeutics (mainly azoles and fluorpirymidins, pigments, chlorhexidine and chlorquinaldol). In ENT practice topical and systemic drugs can be administrated. Topical lozenges include amphotericin B, clotrimazole, chlorhexidine or chlorquinaldol and oral gels: nystatin and miconazole. Some of drugs are in the form of suspension/solution, which can be used for inhalation, into the sinus, for swabbing or for lavage: amphotericin B, natamycin, nystatin, clotrimazol, flucytosine, miconazole, fluconazole, vorykonazole, caspofungin. It should be underlined that only a few of dugs can be absorbed from the digestive tract: flucytosine, fluconazole, itraconazole, ketoconazole, miconazole, vorykonazole.

Topics: Administration, Inhalation; Administration, Oral; Administration, Topical; Amphotericin B; Antifungal Agents; Azoles; Clotrimazole; Ear Diseases; Humans; Miconazole; Mycoses; Nystatin; Otitis; Respiratory Tract Infections

To report otomycosis in a retrospective study and correlate clinical, epidemiological and therapeutic factors.. This study comprises 97 cases of clinically and mycologically proven otomycosis or fungal otitis externa gathered during a 12-year period.. Most cases were unilateral (90.7%) and the main predisposing factors associated with the disease were trauma (secondary to the constant scratching) and the use of topical antibiotics. Major causal agents were several species of Aspergillus (63.9%), of which Aspergillus flavus was commonest (26%), followed by Candida albicans (26.8%) and Aspergillus niger (21%).. The treatment of choice is mainly local toilet of the external auditory canal and the use of systemic antifungal agents to prevent re-infection and the spread of disease.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Aspergillosis; Aspergillus flavus; Aspergillus niger; Child; Ear Diseases; Female; Humans; Male; Merbromin; Middle Aged; Mycoses; Nystatin; Retrospective Studies

Topics: Ear Diseases; Ethylmercury Compounds; Humans; Mouth Diseases; Mycoses; Nystatin; Thimerosal

Topics: Administration, Topical; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Drug Combinations; Ear; Ear Diseases; Framycetin; Hexachlorocyclohexane; Mite Infestations; Nystatin; Prednisolone

5 cases of Nigerian children, all below 2 years of age are presented. Common to all is a history of treated ear infections with subsequent development of otorrhoea. Both smears and cultures of the ear swabs documented candida albicans, and all the patients responded well to oral Nystatin. There is as yet little emphasis in published works on the relationship between candida albicans and draining ears.

Topics: Administration, Oral; Candidiasis; Child; Child, Preschool; Ear Diseases; Female; Humans; Infant; Male; Nystatin

Topics: Aspergillosis; Aspergillus; Cerumen; Chlorides; Ear Diseases; Escherichia coli; Glucose; Humans; Hydrogen-Ion Concentration; Nystatin; Postoperative Complications; Pseudomonas aeruginosa; Staphylococcus; Sulfates