nystatin-a1 and Dermatomycoses

Topics: Administration, Oral; AIDS-Related Opportunistic Infections; Antifungal Agents; Dermatomycoses; Female; Humans; Incidence; Male; Nystatin; Penicillium; Prognosis; Risk Factors

Two patients with cutaneous alternaria infection are presented. In both patients the skin lesions were characterized by multiple non-healing ulcers covered with dry crusts. Although the skin changes were macroscopically alike in the two patients, differences in the histology were seen. Both patients had primary debilitating diseases. A review of the literature is presented and revealed an additional ten cases of cutaneous alternariosis. Methods for the isolation of Alternaria and the susceptibility of the fungus to antimycotic drugs are presented.

Topics: Adolescent; Adult; Alternaria; Amphotericin B; Child, Preschool; Chlorquinaldol; Dermatomycoses; Female; Flucytosine; Gentian Violet; Griseofulvin; Humans; Male; Middle Aged; Mitosporic Fungi; Nystatin; Potassium Permanganate; Skin Ulcer

Twenty-five years ago many of the topical remedies for superficial mycoses were irritating, toxic, or allergenic. Total x-ray depilation of the scalp was the accepted mode of therapy for tinea capitis. The introduction of topical nystatin for candidiasis and tolnaftate for dermatophytosis were major advances, but tinea capitis, onychomycosis, and chronic tinea pedis still presented problems. Soon after its introduction in 1958, griseofulvin became the definitive form of therapy for all types of dermatophytosis and played a major role in abolishing large-scale epidemics of tinea capitis in some countries. Recently, haloprogin and the imidazole derivatives, miconazole and clotrimazole, which are topically active against dermatophytes and Candida albicans, have become available. Selective indicator media for isolating dermatophytes are useful diagnostic tools, but quicker methods of diagnosis which require little interpretation are still lacking. Epidemiologic studies in Vietnam again revealed the effects of climate and occlusion on the prevalence, incidence, and severity of superficial mycoses and led to renewed interest in host susceptibility, environment, and prevention of infections.

Topics: Administration, Topical; Adult; Animals; Antifungal Agents; Arthrodermataceae; Candidiasis; Dermatomycoses; Female; Griseofulvin; Hair Removal; Humans; Male; Nystatin

Topics: Administration, Topical; Adrenal Cortex Hormones; Antifungal Agents; Candidiasis; Dermatomycoses; Female; Humans; Middle Aged; Nails; Nystatin; Paronychia; Skin Diseases

Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Blastomycosis; Candicidin; Candidiasis; Coccidioidomycosis; Colistin; Cryptococcosis; Dermatomycoses; Drug Resistance, Microbial; Emetine; Flucytosine; Griseofulvin; Histoplasmosis; Humans; Imidazoles; Minocycline; Natamycin; Nystatin; Polyenes; Tolnaftate

Topics: Alkenes; Amphotericin B; Animals; Antifungal Agents; Aspergillus; Benzene Derivatives; Candida; Dermatomycoses; Flucytosine; Griseofulvin; Humans; Imidazoles; Kinetics; Mice; Microsporum; Mycoses; Natamycin; Nystatin; Trichophyton

Topics: Acne Vulgaris; Alopecia; Balanitis; Candidiasis; Dermatitis, Occupational; Dermatomycoses; Diaper Rash; Drug-Related Side Effects and Adverse Reactions; Eczema; Erectile Dysfunction; Estrogens; Female; Glucocorticoids; Griseofulvin; Humans; Keloid; Male; Nystatin; Paronychia; Psoriasis; Scabies; Sexually Transmitted Diseases; Skin Diseases; Varicose Veins; Vitamins

In a double-blind trial clotrimazole cream was compared with tolnaftate cream in the treatment of dermatophytoses and with nystatin cream in the treatment of candidoses. Clotrimazole was shown to be effective against both dermatophytoses and candidoses and was as effective and acceptable as tolnaftate and nystatin creams in each condition.

Topics: Administration, Topical; Adolescent; Adult; Antifungal Agents; Arthrodermataceae; Candida; Candidiasis, Cutaneous; Child; Child, Preschool; Clinical Trials as Topic; Clotrimazole; Dermatomycoses; Epidermophyton; Female; Humans; Male; Microsporum; Middle Aged; Nystatin; Skin; Tinea; Tolnaftate; Trichophyton

Topics: Candidiasis; Clinical Trials as Topic; Clotrimazole; Dermatomycoses; Humans; Imidazoles; Nystatin; Tinea; Tolnaftate

Topics: Adolescent; Adult; Animals; Candidiasis; Clinical Trials as Topic; Clotrimazole; Dermatomycoses; Erythrasma; Female; Humans; Imidazoles; Male; Middle Aged; Nystatin; Rats; Salicylates; Tinea; Tinea Versicolor

Topics: Benzoates; Candidiasis; Clinical Trials as Topic; Clotrimazole; Dermatomycoses; Humans; Imidazoles; Nystatin; Tinea; Tinea Versicolor

Superficial fungal infections are among the most commonly managed skin problems by general practitioners. Although evidence shows combination antifungal/corticosteroid topicals are more expensive and less effective than single-agent antifungals, practitioners continue to prescribe combination agents. We examined current prescription trends of 2 combination antifungal/corticosteroid medications, Lotrisone and Mycolog-II.

Topics: Adolescent; Anti-Inflammatory Agents; Antifungal Agents; Betamethasone; Child; Child, Preschool; Clotrimazole; Dermatomycoses; Drug Combinations; Glucocorticoids; Gramicidin; Humans; Infant; Infant, Newborn; Neomycin; Nystatin; Practice Patterns, Physicians'; Triamcinolone Acetonide

A male infant of 2,900 g was born at term to a 19-year-old primigravida woman who had adequate prenatal care and no major complications detected during the pregnancy. The only reported medical event was an episode of urinary tract infection by E. coli one month before delivering, which resolved without complications using nitrofurantoin. There was no history of maternal herpes simplex infection and her serologic screening was negative for syphilis.

Topics: Adult; Antifungal Agents; Asymptomatic Infections; Candidiasis; Dermatomycoses; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Nystatin; Pregnancy; Pregnancy Complications, Infectious; Young Adult

Paecilomyces lilacinus causes multiple diseases in humans, especially in immunocompromised patients. Cutaneous infections are the second most commonly encountered circumstance. We describe a woman with liver cirrhosis with hemorrhagic, bullous, ulcerative leg lesions caused by Paecilomyces lilacinus. The lesions improved after treatment with oral voriconazole and topical nystatin powder. We also reviewed previously reported cases of cutaneous P. lilacinus infection that were treated by oral voriconazole.

Topics: Administration, Oral; Administration, Topical; Aged; Antifungal Agents; Dermatomycoses; Female; Humans; Liver Cirrhosis; Mycoses; Nystatin; Paecilomyces; Pyrimidines; Skin Ulcer; Treatment Outcome; Triazoles; Voriconazole

Penicilliosis is a systemic fungal infection caused by Penicillium marneffei. The infection is most commonly seen in Southeast Asia, Southern China, Hong Kong, and Taiwan. It is rarely seen among individuals of African descent. Here, we report a case of penicilliosis in an African man from Namibia who was studying in Malaysia. He presented with multiple umbilicated papules associated with cough, fever, loss of appetite, and weight. He also had urethral discharge and admitted to unprotected sexual intercourse with multiple partners. Histopathological examination of a skin papule showed the presence of multiple 2 to 4 microm intracellular yeast cells. Culture of the papule revealed Penicillium marneffei. The serology for human immunodeficiency virus (HIV) was positive. This case illustrates the need to recognize penicilliosis in any individuals staying or travelling to Southeast Asia and the need to look for underlying HIV infection in adults with umbilicated papules.

Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Antiretroviral Therapy, Highly Active; Dermatomycoses; Doxycycline; Humans; Itraconazole; Male; Nystatin; Penicillium; Urethritis; Young Adult

Invasive aspergillosis seems to be on the rise, especially in immunocompromised children. Historically, only systemic amphotericin B has been effective against Aspergillus. Development of newer antifungal agents, such as voriconazole and caspofungin, has improved the treatment options available for aspergillosis, although no definitive management strategy has been established. Here we describe the use of topical voriconazole combined with systemic antifungal agents for cutaneous aspergillosis in a pediatric patient after bone marrow transplant.

Topics: Administration, Cutaneous; Adult; Amphotericin B; Anemia, Aplastic; Antifungal Agents; Aspergillosis; Aspergillus flavus; Bone Marrow Transplantation; Combined Modality Therapy; Debridement; Dermatomycoses; Disease Susceptibility; Female; Graft vs Host Disease; Humans; Immunocompromised Host; Injections, Subcutaneous; Nystatin; Postoperative Complications; Pyrimidines; Skin; Transplantation, Homologous; Triazoles; Voriconazole

The antifungal activity of beta-thujaplicin was evaluated against 51 Malassezia pachydermatis strains isolated from canine ear canals with or without otitis externa. For comparison, sensitivity tests were performed on M. pachydermatis isolates for nystatin, ketoconazole, and terbinafine HCl, all clinically available antifungal agents. The minimal inhibition concentrations over 50% of the tested isolates (MIC50) were 3.13 microg/ml for beta-thujaplicin and nystatin, 0.016 microg/ml for ketoconazole, and 1.56 microg/ml for terbinafine HCl. The antifungal effect for M. pachydermatis of beta-thujaplicin compared favorably with commercial antifungal agents. None of the 51 M. pachydermatis isolates showed resistance against any of the tested antibiotics investigated in this study. Ten representative isolates of M. pachydermatis were subcultured for 30 generations at concentrations close to the MIC levels of beta-thujaplicin, nystatin, ketoconazole, and terbinafine HCl, and examined to determine whether they had acquired resistance to each drug. As a result, M. pachydermatis was found to achieve resistance more easily for ketoconazole and terbinafine HCl than for beta-thujaplicin or nystatin. The MIC50 of beta-thujaplicin did not change during the course of subculture, and it is thought that the potential development of a resistant strain is low, even with continuous infusion for otitis externa therapy. beta-Thujaplicin is an inexpensive and safe treatment with anti-inflammatory and deodorant effects that can be recommended as an effective remedy for canine otitis externa.

Topics: Animals; Antifungal Agents; Dermatomycoses; Dog Diseases; Dogs; Drug Resistance, Fungal; Ketoconazole; Malassezia; Microbial Sensitivity Tests; Monoterpenes; Naphthalenes; Nystatin; Otitis Externa; Species Specificity; Terbinafine; Tropolone

Hamycin activity (in vitro) against Malassezia ovale was studied and compared with old and newly discovered polyene antifungal antibiotics. Hamycin showed a marked anti-M. ovale activity which was enhanced in the presence of divalent cations like Cu++ and Zn++. Furthermore, the absorption of hamycin onto the cell membrane or cell surface of M. ovale was also increased in the presence of divalent cations. It is suggested that hamycin alone or along with metal ions, specifically Cu++ may be useful clinically in the treatment of dandruff or seborrheic dermatitis.

Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Copper Sulfate; Dermatitis, Seborrheic; Dermatomycoses; Humans; Macrolides; Malassezia; Microbial Sensitivity Tests; Nystatin; Polyenes; Zinc Sulfate

Topics: Adolescent; Adult; Aged; Bacterial Infections; Child; Child, Preschool; Dermatomycoses; Drug Combinations; Drug Evaluation; Drug Tolerance; Female; Humans; Infant; Male; Middle Aged; Neomycin; Nystatin; Ointments; Skin Diseases, Infectious; Triamcinolone Acetonide

The drugs used in the treatment of superficial mycoses include substances with an indirect affect on the organisms such as the keratolytics as well as antifungal compounds. The antifungals include specific inhibitory compounds such as the polyene or imidazole antibiotics and substances with a wider spectrum of antiseptic activity. High cure rates (80-90%) can be achieved by most specific antifungals although this can be affected by the host response and the location of the infection. The orally active antifungals used in superficial disease, ketoconazole and griseofulvin, can be used in conditions unresponsive or inaccessible to topical therapy, such as chronic superficial candidosis and tinea capitis. However, the treatment of onychomycosis, particularly affecting toe nails, is highly unsatisfactory. There is therefore an important place for new drugs and new methods of applying them in the treatment of superficial (local) mycoses.

Topics: Administration, Oral; Administration, Topical; Amphotericin B; Antifungal Agents; Benzoates; Dermatomycoses; Drug Combinations; Etretinate; Female; Griseofulvin; Humans; Imidazoles; Ketoconazole; Nystatin; Potassium Permanganate; Resorcinols; Salicylates; Salicylic Acid; Suppositories; Tretinoin; Vagina

Topics: Adult; Amphotericin B; Antifungal Agents; Child; Dermatomycoses; Female; Griseofulvin; Humans; Male; Mycoses; Nystatin; Pyrrolidinones

Topics: Amphotericin B; Antifungal Agents; Candidiasis; Clotrimazole; Dermatomycoses; Griseofulvin; Humans; Miconazole; Nystatin; Phenyl Ethers; Tolnaftate

Topics: Candidiasis, Cutaneous; Candidiasis, Oral; Dermatomycoses; Diagnosis, Differential; Griseofulvin; Humans; Nystatin; Tinea

Topics: Adult; Breast Diseases; Candidiasis, Cutaneous; Dermatomycoses; Female; Humans; Nystatin

The new therapeutic methods based on antibiotics, corticosteroids and immunosuppressors and the new medicosurgical techniques (catheters, monitoring in intensive-care units, open-heart surgery) modify the host, favorise the adaptation and introduction f endogenous and exogenous yeast-like fungi and thus create a new pathology characterized by deep visceral or septicemic infections due to yeasts belonging to the genera Candida, Torulopsis, Cryptococcus, Trichosporon, Rhodotorula, and Saccharomyces. The pathological aspects are analyzed and therapy is suggested in the light of new findings on polyenes (nystatine, amphotericine B), 5-fluorocytosine, imidazole, derivatives (miconazole, econazole) considering their association in function of synergy or antagonism possibilities.

Topics: Amphotericin B; Candida; Candidiasis; Cryptococcosis; Dermatomycoses; Endocarditis; Flucytosine; Humans; Iatrogenic Disease; Imidazoles; Lung Diseases, Fungal; Mycoses; Nystatin; Osteitis; Sepsis; Urinary Tract Infections

Molds are vegetable microorganisms, which differ from dermatophytes sensitive to griseofulvin, and from yeasts, which do not form aerial mycelium. Most of the molds, phytopathogenic or which live from dead organic substances, are apathogenic to humans. Only a couple of dozen species can parasitize on the skin, usually together with dermatophytes or yeasts. Onychomycoses with molds appear mostly in elderly people, and fungus affections of external auditory passage in seborrheic eczema of the ear. The hair can be infected by Piedraia hortae, resulting in hard black nodules. After the identification of molds on the skin, criticism is necessary, since in more than 95% of the cases they are accidental germs. Several cultures and microscopic tests are necessary to assure the diagnosis. Broad-spectrum antimycotics is the predominant choice for treatment, but also amphotericin B, nystatin and pimaricin.

Topics: Amphotericin B; Dermatitis, Seborrheic; Dermatomycoses; Humans; Natamycin; Nystatin; Onychomycosis; Piedra

The manifestation of a mycotic infection can be prevented by exposition prophylaxis, disposition prophylaxis or chemoprophylaxis. The main statements are discussed. Protective measurements are helpful provided the instructions are followed continually. One must pay attention to one's personal hygiene. The environmental sanitation can be also important.

Topics: Amphotericin B; Animals; Arthrodermataceae; Cattle; Dermatomycoses; Disinfectants; Dogs; Female; Humans; Hygiene; Infant, Newborn; Nystatin; Swimming Pools

Topics: Amphotericin B; Burns; Dermatomycoses; Humans; Male; Middle Aged; Nystatin

Topics: Amphotericin B; Animals; Antifungal Agents; Cycloheximide; Dermatomycoses; Female; Guinea Pigs; Male; Mice; Mitosporic Fungi; Natamycin; Nystatin; Rabbits

Topics: Amphotericin B; Antifungal Agents; Dermatomycoses; Griseofulvin; Humans; Mycoses; Nystatin; Penicillins; Potassium Iodide; Stilbamidines; Sulfonamides

Topics: Antifungal Agents; Candidiasis, Cutaneous; Chlorphenesin; Dermatomycoses; Griseofulvin; Humans; Nystatin; Pyrrolidinones; Undecylenic Acids

Topics: Candida; Dermatomycoses; Eczema; Female; Genitalia; Germany, East; Humans; Male; Mouth Mucosa; Mucous Membrane; Nystatin; Skin; Skin Diseases; Skin Ulcer; Stomatitis; Yeasts

Topics: Adult; Amphotericin B; Antifungal Agents; Child; Dermatomycoses; Griseofulvin; Humans; Nystatin; Tinea

Topics: Amphotericin B; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Dermatomycoses; Humans; Nystatin; Phenols; Quaternary Ammonium Compounds; Quinolines; Salicylates; Sulfides; Sulfonamides; Sulfones; Thiocarbamates

Topics: Antifungal Agents; Dermatomycoses; Griseofulvin; Humans; Nystatin

Topics: Dermatomycoses; Griseofulvin; Humans; Iodine; Nystatin

Topics: Actinomycosis; Adult; Amphotericin B; Aspergillosis; Blastomycosis; Candidiasis, Vulvovaginal; Child; Cryptococcosis; Dermatomycoses; Female; Griseofulvin; Humans; Lung Diseases, Fungal; Mycetoma; Mycoses; Nails; Nocardia Infections; Nystatin; Skin Diseases; Sporotrichosis; Stilbamidines; Thallium; Tinea Pedis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Dermatomycoses; Humans; Nystatin; Tinea