nystatin-a1 and Dermatitis--Atopic

Topics: Administration, Oral; Adult; Antifungal Agents; Candidiasis, Oral; Dermatitis, Allergic Contact; Dermatitis, Atopic; Diagnosis, Differential; Facial Dermatoses; Humans; Male; Nystatin; Patch Tests

We studied whether fungal allergens play a role in exacerbating the clinical symptoms of atopic dermatitis (AD). We found that the percentage of the patients who showed CAP-RAST positive (2 < or = score) to Candida albicans (Ca) was significantly higher in the patients with severe symptoms and high serum IgE level than those with mild symptoms and lower IgE. This was also true for the patients with CAP-RAST positive to Pityrosporum ovale (Po). AD patients with their symptoms localized to head and neck showed significantly higher tendency to have positive CAP-RAST (2 < or = score) to Ca and Po when compared to those with their eruption distributing to the extremities. We then evaluated the efficacy of oral therapy with antifungal agents in 140 cases of refractory AD with positive CAP-RAST to Ca. Good or excellent response was obtained in 60% with fluconazole, 35% with itraconazole, 31% with amphotericin B, 28% with nystatin. The present finding that amphotericin B and nystatin, both of which are not absorbed through intestine, were effective for approximately a third of the patients indicates that Ca in the intestine plays an important role in triggering AD symptoms. Fluconazole was more effective than amphotericin B and nystatin, suggesting that fungal colonizing in other parts of the body but the digestive tract also play a role in the exacerbation of AD symptoms.

Topics: Administration, Oral; Adult; Allergens; Amphotericin B; Antifungal Agents; Antigens, Fungal; Candida albicans; Dermatitis, Atopic; Female; Fluconazole; Humans; Itraconazole; Male; Nystatin

Mycolog contact allergy is due primarily to its ethylenediamine and fragrance components. In the evaluation of Mycolog-sensitive patients, the major constituents, including the perfume at 5% or 10% in petrolatum, should be tested.

Topics: Dermatitis, Atopic; Dermatitis, Contact; Dermatologic Agents; Drug Combinations; Ethylenediamines; Gramicidin; Humans; Neomycin; Nystatin; Patch Tests; Perfume; Triamcinolone Acetonide

The effect of synthetic salmon calcitonin was studied on adjuvant arthritis, pertussis vaccine edema, tuberculin skin reaction, passive direct Arthus reaction and nystatin edema. The results show that calcitonin inhibits these inflammatory processes.

Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Calcitonin; Dermatitis, Atopic; Disease Models, Animal; Edema; Inflammation; Nystatin; Pertussis Vaccine; Rats; Time Factors; Tuberculin

Sebaceous gland activity in the newborn and children is extensive at first in the epidermis, and later decreases owing to defective operation of the sweat glands, circulation changes, growth of the hair, and a predisposition to infection, for which significant treatment is required. In addition to the genetic "typus neurodermiticus", pharmaceutical, alimentary and respiratory allergens and psychological factors may play a part in the appearance of atopical dermatitis. Onset is usually in the 2nd to 6th month and the side of the face and the scalp are affected. The clinical picture varies considerably with age and includes sanious foci covered with scabs on the head and eczema flexurarum. Differences in family history, age and the location of sites will distinguish this form from seborrhoeic dermatitis. Gluteal dermitis is secondary to congestion caused by dampness, rugging and soaking, and the action of stools and urine (bacterial amniogenesis). The main complications of neonatal and infantile impetigo are: glomerulonephritis, exfoliative dermatitis, pulmonary abscess, pulmonitis and osteomyelitis; phlyctenular, serpiginous impetigo with large and small bullae is particularly important. Treatment of neonatal and infantile dermatosis must take account of the fact that increased reabsorption and congestion are contraindications for the local application of corticoids and preparations containing salicylic and boric acid.

Topics: Anti-Bacterial Agents; Child, Preschool; Dermatitis, Atopic; Dermatitis, Seborrheic; Diagnosis, Differential; Diet Therapy; Eczema; Humans; Hypnotics and Sedatives; Impetigo; Infant; Infant, Newborn; Infant, Newborn, Diseases; Neurodermatitis; Nystatin; Oils; Ointments; Salicylates; Skin Diseases