nystatin-a1 and Dental-Plaque

Topics: Aged; Clinical Trials as Topic; Dental Plaque; Denture Rebasing; Denture, Complete; Female; Humans; Nystatin; Oral Hygiene; Stomatitis; Stomatitis, Denture

To examine the effect of Nystatin oral rinse on oral Candida species and Streptococcus mutans carriage.. Twenty healthy adults with oral candidiasis participated in the single-arm clinical trial and received Nystatin oral rinse for 7 days, 4 applications/day, and 600,000 International Units/application. Demographic-socioeconomic-oral-medical conditions were obtained. Salivary and plaque Candida species and Streptococcus mutans were assessed at baseline and 1-week and 3-month follow-ups. Twenty-four salivary cytokines were assessed. Candida albicans isolates underwent Nystatin susceptibility test.. Half of participants (10/20) were free of salivary C. albicans after using Nystatin rinse. Salivary S. mutans was significantly reduced at 3-month follow-up (p < 0.05). Periodontal status reflected by bleeding-on-probing was significantly improved at 1-week and 3-month follow-ups (p < 0.05). Plaque accumulation was significantly reduced at 1-week follow-up (p < 0.05). Interestingly, the responses to Nystatin oral rinse were not associated with race, gender, age, oral hygiene practice, adherence to Nystatin rinse, or sweet consumption (p > 0.05). No C. albicans isolates were resistant to Nystatin. Furthermore, salivary cytokine eotaxin and fractalkine were significantly reduced at 3-month follow-up among participants who responded to Nystatin rinse (p < 0.05).. The study results indicate that oral antifungal treatment had an effect on S. mutans salivary carriage. Future clinical trials are warranted to comprehensively assess the impact of antifungal treatment on the oral flora other than S. mutans and Candida.. Due to the potential cariogenic role of oral Candida species, antifungal approaches shed new light on the prevention and management of dental caries from a fungal perspective.

Topics: Adult; Antifungal Agents; Candida; Candida albicans; Dental Caries; Dental Plaque; Humans; Mouthwashes; Nystatin; Streptococcus mutans

Topics: Candidiasis, Oral; Chlorhexidine; Dental Plaque; Denture, Complete; Humans; Nystatin; Stomatitis; Stomatitis, Denture

The material comprised 48 patients, 19 exhibiting atrophic and 29 hyperplastic denture stomatitis. Twenty-seven patients with healthy mucosa served as a reference group. Past history, resilience of the mucosa, denture function and scores of palatal erythema, plaque and yeasts were recorded. The therapeutic program included new dentures, surgical and nystatin treatment, hygienic instruction and nutritional advice. The result concerning past history showed significantly more smokers, more patients with recurrent urinary tract infections in combination with prolonged antibiotic therapy, and more patients wearing their dentures at night in the denture stomatitis group. Nystatin treatment did not affect the healing of palatal erythema evaluated after 1 year. The treatment program evaluated after 1 year resulted in complete healing of the mucosa in 50% of patients. The remaining 50% had persisting erythema of varying intensity. The unhealed cases showed significantly more yeasts and plaque on the denture bas compared to the healed patients and the reference group. An evaluation of factors common to failure of healing is presented.

Topics: Adult; Aged; Dental Plaque; Denture, Complete, Upper; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Male; Medical History Taking; Middle Aged; Nutritional Physiological Phenomena; Nystatin; Oral Hygiene; Yeasts