nystatin-a1 and Deglutition-Disorders

Dysphagia following cardiac surgery is a frequently encountered problem, being most commonly due to the sternotomy incision and/or prolonged intubation. Oesophageal candidiasis is an increasing problem that is usually associated with immunosuppression or immunodeficiency. We report a 59 years age, immunocompetent lady whom had developed dysphagia and odynophagia following open cardiac surgery and long term course of antibiotics. Diagnosis of Candida oesophagitis was established after radiological, endoscopic and microbiological evidence, and successful treatment with combined topical and systemic antifungal therapy was achieved. Possibility of immunodeficiency was excluded. We believe that this lady developed oesophageal candidiasis due to a long-term course of broad spectrum antibiotics. We discuss the various diagnostic modalities and treatment options.

Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Oral; Deglutition Disorders; Dilatation; Drug Therapy, Combination; Esophagitis; Female; Humans; Immunocompetence; Middle Aged; Nystatin; Thoracic Surgery; Treatment Outcome

An 85-year-old man with myasthenia gravis was successfully treated with methotrexate (10 mg/week), pyridostigmine and prednisolone (0-30 mg/day) for over 10 years. Then, he developed dysphagia and lost weight. Gastroscopy revealed Candida esophagitis. The patient received nystatin for 2 weeks. Methotrexate was stopped, and immunosuppressive therapy was continued with prednisolone alone. The patient has now remained in good condition for over 1 year. Although dysphagia is a typical symptom of myasthenia gravis, swallowing disturbances should not be attributed hastily to this disease, since they may also be a complication of therapy.

Topics: Aged; Antifungal Agents; Candidiasis; Deglutition Disorders; Diagnosis, Differential; Drug Therapy, Combination; Esophagitis; Gastroscopy; Humans; Immunosuppressive Agents; Male; Methotrexate; Myasthenia Gravis; Nystatin; Prednisolone; Pyridostigmine Bromide

Topics: Antifungal Agents; Candidiasis, Oral; CD4 Lymphocyte Count; Clotrimazole; Deglutition Disorders; HIV Infections; Humans; Immunocompromised Host; Male; Nystatin; Young Adult

High-intensity impulse laser radiation proved effective in 23 patients with esophageal candidiasis. The highest effect was achieved in its use with nistatin. In low laser efficacy radiation should be combined with transendoscopic administration of granulocytes concentrate. This produced clinico-endoscopic remission in 98.3% of the cases.

Topics: Adult; Antifungal Agents; Candidiasis; Combined Modality Therapy; Deglutition Disorders; Esophageal Diseases; Esophagoscopy; Evaluation Studies as Topic; Female; Humans; Laser Therapy; Male; Nystatin

Gastrointestinal Candida infection is more prevalent than previously recognized. It is most often seen in patients with underlying impairment of the immune system but may also occur in apparently normal individuals. Esophageal involvement is most common, presenting with odynophagia, dysphagia, or bleeding. Gastric Candida infection may cause diffuse mucosal involvement or focal invasion of benign gastric ulcers. Intestinal candidiasis is uncommon and poorly characterized. The diagnosis is usually established by visualizing the characteristic yeast or mycelial forms in endoscopic brushings and biopsies. Oral nystatin is effective therapy in many patients, but other antifungal agents may be needed in extensive or persistent disease, especially in immunocompromised patients.

Topics: Candidiasis; Deglutition Disorders; Diagnosis, Differential; Esophageal Diseases; Flucytosine; Humans; Imidazoles; Intestinal Diseases; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Nystatin; Polyenes; Stomach Diseases

A 35-year-old man with idiopathic hypoparathyroidism and moniliasis developed progressive dysphagia and weight loss. Diagnostic studies established the presence of esophageal moniliasis. Therapy with a viscous suspension of nystatin resulted in rapid clinical improvement; prolonged administration of the drug was associated with progressive widening of a narrowed segment of esophagus and complete disappearance of dysphagia. The chemotherapy of esophageal moniliasis is discussed in the light of current knowledge of the pharmacological action of nystatin.

Topics: Administration, Oral; Adult; Candidiasis; Chronic Disease; Deglutition Disorders; Esophageal Diseases; Esophagus; Humans; Male; Nystatin; Radiography; Suspensions; Viscosity

Topics: Amphotericin B; Candida; Candidiasis; Deglutition Disorders; Diagnosis, Differential; Esophageal Diseases; Female; Humans; Infusions, Parenteral; Middle Aged; Nystatin; Radiography

Topics: Candida; Candidiasis; Deglutition Disorders; Esophageal Stenosis; Esophagitis; Humans; Male; Middle Aged; Nystatin; Radiography

Topics: Achlorhydria; Anemia; Candidiasis; Candidiasis, Oral; Cheilitis; Deglutition Disorders; Drug Therapy; Geriatrics; Humans; Nystatin; Plummer-Vinson Syndrome; Postgastrectomy Syndromes; Tongue Diseases

Topics: Anti-Bacterial Agents; Candidiasis; Candidiasis, Oral; Deglutition Disorders; Diagnosis; Esophagitis; Humans; Nystatin; Pneumonia; Prednisolone; Radiography; Sulfonamides; Tetracycline

Topics: Candida albicans; Candidiasis; Candidiasis, Oral; Deglutition Disorders; Esophagitis; Esophagoscopy; Humans; Lung Neoplasms; Nystatin; Oxytetracycline; Penicillins; Speech Disorders; Vocal Cord Paralysis