nystatin-a1 and Conjunctivitis

The author presents the case-history of a 19-year-old female patient with subacute bilateral conjunctivitis, where based on repeated cultivation form the conjunctival sac Candida albicans was proved as the aetiological agent. After the application of Nystatin (Fungicidin Spofa ointment, dragée) marked immediate improvement of the clinical finding was recorded and gradual regression of follicles and tarsal squamous hyperplasia. The author discusses possible types of mycotic conjunctivitis with regard to the character of the inflammation, the aetiological agent and treatment.

Topics: Adult; Candidiasis; Conjunctivitis; Female; Humans; Nystatin

Various tests were used in order to ascertain any irritating, sensitising or toxic potential of alpha-(2,4-dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) when applied to the skin or to mucous membranes in gel or cream formulation. When instilled into the conjunctival sac in rabbits fenticonazole led to a slight reddening of the mucosa in only one animal. The reddening appeared 1 h after treatment and disappeared within 24 h. Guinea pigs topically treated for 20 days with fenticonazole 2% gel or cream showed mild erythema which appeared 5 days after the beginning of the treatment and virtually disappeared at the end of the treatment. The treatment with fenticonazole 2% gel or cream did not induce sensitisation. Fenticonazole was not phototoxic or photosensitising when a 2% gel or cream formulation was applied topically to guinea pigs, at the dosage of 0.1 ml per animal.

Topics: Administration, Topical; Animals; Conjunctivitis; Griseofulvin; Guinea Pigs; Imidazoles; Miconazole; Mucous Membrane; Nystatin; Photosensitivity Disorders; Rabbits; Skin

Topics: Adolescent; Aspergillosis; Child; Conjunctivitis; Female; Humans; Nystatin

Topics: Actinomycosis; Amphotericin B; Animals; Antifungal Agents; Atropine; Chorioretinitis; Conjunctivitis; Eye Diseases; Hot Temperature; Humans; Laser Therapy; Light Coagulation; Mycoses; Natamycin; Nocardia Infections; Nystatin; Penicillins; Rabbits; Sporotrichosis; Streptomycin; Sulfacetamide; Sulfadiazine; Vitreous Body

Topics: Blepharitis; Candidiasis; Conjunctivitis; Humans; Nystatin