nystatin-a1 and Chronic-Disease

Topics: Amphotericin B; Antifungal Agents; Chronic Disease; Flucytosine; Humans; Imidazoles; Mycoses; Natamycin; Nystatin; Peptides; Polyenes; Trityl Compounds

Management of oral candidiasis depends on an accurate diagnosis, identification and elimination of predisposing factors, and, often, use of antifungal agents. Chronic hyperplastic candidosis (CHC) is considered a premalignant lesion of the oral mucosa, occurring as speckled or homogeneous white lesions. If the lesions are untreated, a minor proportion may become dysplastic and progress to carcinoma. The traditional treatment of this lesion is based on the use of antifungal agents. The aim of this study was to examine the efficacy of 0.18% isotretinoin for treatment of nystatin-resistant candidiasis. Isotretinoin was administered topically twice a day for one month to six patients affected by nystatin-resistant CHC. In all six patients, daily antimycotic topical therapy with nystatin for 30 days had failed to resolve the candidal stomatitis. After one month of isotretinoin treatment, five of the six patients were negative for Candida, whereas in untreated control patients the situation was unchanged. Only one patient with suspected sicca syndrome was found to have oral Candida 15 days after the last administration of isotretinoin. None of the patients had any complaints about the medication. These findings suggest that 0.18% isotretinoin applied twice a day for one month is able to suppress nystatin-resistant candidiasis.

Topics: Administration, Topical; Antifungal Agents; Candidiasis, Oral; Chronic Disease; Drug Resistance, Fungal; Female; Humans; Isotretinoin; Male; Middle Aged; Nystatin; Pilot Projects

In vitro study of the antibacterial activity of macrolide antibiotics azitromycin (sumamed), midicamycin (macropen), roxitromycin (rulide), and erythromycin demonstrated their high activity towards clinical strains of bacteroids, fusobacteria, peptostreptococci, streptococci, and corynebacteria. These antibiotics were effective in the treatment of 62 adult patients with severe and moderate generalized periodontitis. Rulide and sumamed were the most effective, macropen and erythromycin were inferior to them.

Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Antifungal Agents; Azithromycin; Chronic Disease; Drug Therapy, Combination; Erythromycin; Humans; Leucomycins; Middle Aged; Nystatin; Periodontitis; Roxithromycin

67 women with chronic recurrent or persistent vaginal candidosis between 5-79 years of age were seen in our outdoor department. In 34 cases, yeasts could be isolated in a vaginal swab taken at the first consultation. On average the patients reported 5 episodes per year during the last years. Typical symptoms consisted of pruritus vulvae, local inflammation and a curdy vaginal discharge. Nearly all of the women had received local or systemic antimycotic treatment for several times. In 53% (18 patients), C. albicans had been isolated, in 29% (10 patients) C. glabrata and in 9% (3 patients) C. krusei. While candidosis due to C. albicans and C. krusei was frequently associated with distressing complaints, infections with C. glabrata caused only very few symptoms. Independent of the species, severe and persistent infections were characterized by long term persisting specific IgM-antibody-titers and remarkable lack of IgG-antibodies. The laboratory parameters of WBC, CRP and immunelectrophoresis were normal. The minimum inhibitory concentrations (MIC) of 60 Candida strains against fluconacole were determined by microdilution assay. The MIC for C. albicans (n = 35) were between 0.78 and 3.125 micrograms/ml, for C. glabrata (n = 20) between 8 and 32 micrograms/ml and for C. krusei (n = 5) between 25 and 128 micrograms/ml. In 7 cases, local antimycotic treatment was sufficient. Correlating to the sensitivity, 18 women were treated with 100-800 mg fluconacole/d for 10-20 days. In 13 of them, clearance of symptoms and yeasts was achieved. The treatment of fluconacole-resistant strains with itraconazole (100-200 ml/d for 10-20 days) together with local application of nystatin (2 x 1 Mio. IE for 10 days) was without any effect. Three women with C. albicans, C. glabrata and C. krusei infection received a candidin-vaccination (0.005 BE/ml-500 BE/ml). In all of these cases, production of IgM-antibodies was induced. However, the clinical symptoms could not be influenced. Only in two cases it was not possible to reach a clearance of symptoms and yeasts. The results show the benefit of a precise differentiation before therapy. Serologic controls of antibody titers seem to be useful tools to control the efficacy of treatment.

Topics: Adolescent; Adult; Aged; Antifungal Agents; Candida; Candida albicans; Candidiasis, Vulvovaginal; Child; Child, Preschool; Chronic Disease; Female; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Middle Aged; Nystatin; Recurrence

Otitis externa and chronic otitis media often present to the otolaryngologist with a discharging ear. The conventional method of treatment is to perform regular aural toilet and insert medicated dressings into the external auditory canal. This treatment is either performed by trained nurses or medical staff, but in either case is time consuming. This study compares the efficacy of the above standard regimen with a novel treatment where a single aural toilet is carried out and medicated ointment instilled into the ear. Both regimens were evaluated at three weeks. Our results shows that there was no significant difference between the two treatment regimens with regard to the resolution of either of the conditions studied or the improvement in the symptom status of the patients. On the basis of this it would seem that a single aural toilet and instillation of medicated ointment is a valid treatment option, cuts down hospital attendance and could be performed in the community by general medical practitioners or trained practice nurses.

Topics: Administration, Topical; Chronic Disease; Drug Administration Schedule; Drug Combinations; Gramicidin; Humans; Neomycin; Nystatin; Ointments; Otitis; Otitis Externa; Otitis Media, Suppurative; Triamcinolone Acetonide

Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Clinical Trials as Topic; Dexamethasone; Drug Combinations; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Nystatin; Otitis; Oxytetracycline; Polymyxin B; Polymyxins

In 5 patients (3 children, 2 adults) suffering from familial or non-familial chronic muco-cutaneous Candidosis (CMCC) combined with cellular immune deficiencies of different extent, an immunostimulating therapy regimen with levamisole was performed over 6 months. Post-treatment clinical and immunological re-examinations offered a favourable effect on the cellular immune system in all patients. As to the general health condition, in the children all clinical symptoms of CMCC clearly improved or disappeared completely, whereas in both adult patients no satisfactory clinical effect of levamisole therapy could be observed so far.

Topics: Adult; Candidiasis, Cutaneous; Chemotaxis, Leukocyte; Child; Chronic Disease; Clinical Trials as Topic; Clotrimazole; Drug Evaluation; Drug Therapy, Combination; Female; Granulocytes; Humans; Levamisole; Lymphocytes; Male; Nystatin; Phagocytosis; Tablets; Time Factors

Topics: Administration, Oral; Administration, Topical; Aerosols; Anti-Inflammatory Agents; Asthma; Beclomethasone; Candidiasis; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; Glucocorticoids; Humans; Methylprednisolone; Mouth Diseases; Mouth Mucosa; Nystatin; Pharyngeal Diseases; Placebos; Prednisone; Propionates

This study surveyed the prevalence of massive numbers of Cyniclomyces guttulatus in faecal samples from healthy dogs (18%) and dogs with chronic diarrhoea (14%) suggesting that this yeast has no clinical significance. Subsequently, a total of 57 referred dogs with chronic diarrhoea were selected because they excreted massive numbers of C. guttulatus and their initial diagnostic work-up yielded no other direct clues explaining their diarrhoea. Treatment with nystatin did not result in any clinical response in 36 out of these 57 dogs (63%), although they no longer shed the yeast. However, a response was noted in the remaining 21 (37%) dogs: 13 were 'responders', in that their diarrhoea subsided for more than two weeks and the faeces were cleared of the yeast. However, three of these dogs relapsed repeatedly, with signs of diarrhoea and massive shedding of the yeast. The other eight dogs were 'incomplete responders', whereby faecal quality initially normalised, but diarrhoea relapsed within two weeks, whilst still not shedding the yeast. In these cases, further diagnostic work up revealed other co-causes of diarrhoea. It was concluded that there was no direct evidence that C. guttulatus is a primary pathogen. However, the results of the prospective treatment study suggest that a possible role in a minority of cases, perhaps as an opportunist, cannot be ruled out.

Topics: Animals; Antifungal Agents; Carrier State; Chronic Disease; Diarrhea; Dog Diseases; Dogs; Feces; Female; Male; Netherlands; Nystatin; Prevalence; Prospective Studies; Saccharomycetales

Chronic, non-healing wounds are often characterised by an excessive, and detrimental, inflammatory response. We review our experience of using a combined topical steroid, antibiotic and antifungal preparation in the treatment of chronic wounds displaying abnormal and excessive inflammation.. A retrospective review was undertaken of all patients being treated with a topical preparation containing a steroid (clobetasone butyrate 0.05%), antibiotic and antifungal at a tertiary wound healing centre over a ten-year period. Patients were selected as the primary treating physician felt the wounds were displaying excessive inflammation. Healing rates were calculated for before and during this treatment period for each patient. Changes in symptom burden (pain, odour and exudate levels) following topical application were also calculated.. Overall, 34 ulcers were identified from 25 individual patients (mean age: 65 years, range: 37-97 years) and 331 clinic visits were analysed, spanning a total time of 14,670 days (7,721 days 'before treatment' time, 6,949 days 'during treatment' time). Following treatment, 24 ulcers demonstrated faster rates of healing, 3 ulcers showed no significant change in healing rates and 7 were healing more slowly (p=0.0006). Treatment generally reduced the burden of pain and exudate, without affecting odour.. In normal wound healing, inflammation represents a transient but essential phase of tissue repair. In selected cases, direct application of a steroid containing agent has been shown to improve healing rates, presumably by curtailing this phase. Further evaluation is required to establish the role of preparations containing topical steroids without antimicrobials in the management of chronic wounds.

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Chronic Disease; Clobetasol; Drug Combinations; Female; Glucocorticoids; Humans; Inflammation; Male; Middle Aged; Nystatin; Ointments; Oxytetracycline; Retrospective Studies; Wound Healing

Topics: Administration, Topical; Antifungal Agents; Betamethasone; Chronic Disease; Female; Glucocorticoids; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Middle Aged; Mouth Diseases; Nystatin

Topics: Administration, Oral; Aged, 80 and over; Antifungal Agents; Candidiasis, Oral; Chronic Disease; Hiccup; Humans; Male; Nystatin; Treatment Outcome

To determine clinical variables to distinguish invasive pulmonary aspergillosis (IPA) from colonization in patients with chronic pneumopathies with positive culture of Aspergillus spp. in respiratory samples.. Retrospective cohort study including patients with respiratory isolations of Aspergillus spp. during a period of 10 years. IPA was evaluated according to the Bulpa criteria. Clinical variables were collected and a multiple logistic regression analysis was carried out.. Eighty-three patients with isolation of Aspergillus spp. from respiratory samples were included; 68.7% (n=57) of the patients had chronic obstructive pulmonary disease, 18% (n=15) pulmonary fibrosis and 13.3% (n=11) bronchial asthma. Twenty-two patients (26.6%) had IPA. The use of fluconazole (OR 4.49; CI 95% 1.5-13.4; P=.007), severe respiratory failure (OR 4.64; CI 95% 1.46-14.72; P=.009) and hospitalization time (OR 1.05; CI 95% 1.01-1.1; P=.006) were associated with IPA.. Prior use of fluconazole, severe respiratory failure and hospitalization time are associated with IPA in patients with chronic pneumopathies with respiratory isolation of Aspergillus spp.

Topics: Aged; Aged, 80 and over; Antifungal Agents; Aspergillus; Asthma; Bacterial Infections; Carrier State; Chronic Disease; Comorbidity; Cross Infection; Diagnosis, Differential; Disease Susceptibility; Female; Fluconazole; Hospitals, University; Humans; Incidence; Invasive Pulmonary Aspergillosis; Length of Stay; Lung; Lung Diseases; Male; Middle Aged; Nystatin; Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis; Respiratory Insufficiency; Retrospective Studies; Risk Factors; Spain

The anti-inflammatory effect of Arnica montana 6cH was evaluated using acute and chronic inflammation models. In the acute, model, carrageenin-induced rat paw oedema, the group treated with Arnica montana 6cH showed 30% inhibition compared to control (P < 0.05). Treatment with Arnica 6cH, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process. In the chronic model, Nystatin-induced oedema, the group treated 3 days previously with Arnica montana 6cH had reduced inflammation 6 h after the inflammatory agent was applied (P < 0.05). When treatment was given 6 h after Nystatin treatment, there was no significant inhibitory effect. In a model based on histamine-induced increase of vascular permeability, pretreatment with Arnica montana 6cH blocked the action of histamine in increasing vascular permeability.

Topics: Acute Disease; Analysis of Variance; Animals; Anti-Inflammatory Agents; Arnica; Carrageenan; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Foot Diseases; Granulation Tissue; Inflammation; Male; Nystatin; Phytotherapy; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Time Factors

The purpose of this study was to determine the extent and outcome of antifungal treatment in HIV/AIDS patients. Data obtained from patients attending a hospital-based, semi-urban comprehensive care HIV clinic, were retrospectively analysed. The clinic serves patients from urban, semi-urban and rural communities. A total of 751 confirmed black heterosexual HIV/AIDS patients received routine oral examinations and surveillance swabbing for oral yeast culture. Patients received nystatin solution as prophylaxis, miconazole for clinically detectable oral candidiasis and only in severe cases or cases of chronic candidiasis were they treated with either fluconazole or itraconazole. Treatment was regarded as successful when there was an absence or resolution of clinical lesions of oral candidiasis. Nystatin prophylaxis was prescribed to 7.9% of patients, miconazole treatment to 9.7% and 3.5% received fluconazole. Of the 60 patients who received nystatin prophylaxis, 40 (66.6%) had clinically detectable candidiasis. A negative statistical correlation was found between nystatin prophylaxis and clinically detectable candidiasis. Of 72 patients who received miconazole treatment, only 3 failed to respond. Eleven of the 27 patients who received fluconazole treatment did not return for follow-up visits. In the remaining 16 patients there was no recurrence of clinical symptoms during the following 3 - 24 months after treatment with fluconazole. It is concluded that nystatin prophylaxis proved not to be effective under these particular clinical circumstances. Resistance to azole antifungal medication is not yet a problem in this black heterosexual group of South African HIV/AIDS patients.

Topics: Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; Antifungal Agents; Candidiasis, Oral; Chemoprevention; Chronic Disease; Cohort Studies; Comprehensive Health Care; Female; Fluconazole; Follow-Up Studies; Heterosexuality; Humans; Itraconazole; Male; Miconazole; Middle Aged; Nystatin; Population Surveillance; Retrospective Studies; South Africa; Treatment Outcome

The case of a 66-year-old female patient is presented, who suffered from chronic watery diarrhea. In addition, she developed linear IgA dermatosis after oral treatment of a presumed yeast infection with nystatin. To evaluate the reason for her diarrhea, colonoscopy was performed. The macroscopic aspect of the colon mucosa was described as normal with no specific alterations for chronic inflammatory bowel disease or for bacterial infections. In contrast, the histologic examination revealed the typical characteristics of lymphocytic colitis. This disease is thought to be caused by immunological reactions against as yet unknown luminal antigens. After treatment with steroids and dapsone the diarrhea as well as the skin disease disappeared. To our knowledge, the present report describes for the first time the association of linear IgA dermatosis with lymphocytic colitis after oral treatment with nystatin. A possible causative link between these two disease entities is discussed.

Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Biopsy; Blotting, Western; Chronic Disease; Colitis; Colon; Colonoscopy; Dapsone; Diarrhea; Female; Fluorescent Antibody Technique, Direct; Humans; Immunoglobulin A; Lymphocytes; Methylprednisolone; Nystatin; Skin; Skin Diseases

Ten hospitalized patients with severe diarrhea associated with intestinal Candida overgrowth are reported. Candida-associated diarrhea is predominantly of the secretory type, characterized by frequent watery stools, usually without blood, mucus, tenesmus, or abdominal pain. The patients were elderly, malnourished, and critically ill, or suffered from chronic debilitating illness. Their hospital stays were prolonged, and the majority were being treated with multiple antibiotics or chemotherapeutic agents. Diarrhea often led to dehydration, prerenal azotemia, hyperchloremic metabolic acidosis, and electrolyte imbalance. Stool culture most frequently isolated Cand. albicans in association with decreased normal flora. Colonoscopy showed no evidence of colitis. Diagnosis was made based on the absence of diarrhea-producing medications, the continuation of diarrhea despite fasting, the exclusion of other infections, inflammatory conditions and other causes of secretory diarrhea, and a dramatic response to a short course of nystatin.

Topics: Aged; Aged, 80 and over; Candida; Candidiasis; Chronic Disease; Cross Infection; Diarrhea; Drug Therapy, Combination; Feces; Female; Humans; Male; Middle Aged; Nutrition Disorders; Nystatin

We compared the clinical efficacy of Auricularum to its bacteriological efficacy in 36 patients with a chronic middle ear disease. The clinical study confirms the very good efficacy of Auricularum with an improvement rate equal to 81% and 69.4% of "very good" results. The bacteriological study confirms the usual sensitivity of gram-negative bacilli (except the Proteus) to polymyxine B, the sensitivity of gram-positive germs to tetracycline for 60% of them and the sensitivity of fungus (isolated only once) to nystatine. Moreover, the bacteriological study shows that Auricularum with a concentration more or equal to 0.1 ml inhibits every germ, including the well-known resistant germs. This concentration of 0.1 ml corresponds to 2 drops of the drug in suspension and is less than the recommended dosage. This finding proves the very good efficacy of Auricularum in chronic middle ear diseases, including the ones due to usual resistant germs to the two antibiotics (polymyxine B and oxytetracycline) enclosed in the drug composition.

Topics: Bacteriological Techniques; Chronic Disease; Dexamethasone; Drug Combinations; Humans; Microbial Sensitivity Tests; Nystatin; Otitis Media; Oxytetracycline; Polymyxin B; Polymyxins

The antifungal treatment of recurrent vulvo-vaginal candidosis is described. Factors which predispose to the condition are discussed and details of their investigation and management mentioned. The problem of reinfection, both from a sexual contact and from the bowel is reviewed, and the general features of management considered.

Topics: Adrenal Cortex Hormones; Boric Acids; Candidiasis, Vulvovaginal; Chronic Disease; Clotrimazole; Contraceptives, Oral; Diabetes Complications; Female; Humans; Menstrual Cycle; Miconazole; Nystatin; Patient Compliance; Rectum; Sexual Behavior; Suppositories; Thyroid Function Tests; Vagina

Topics: Adult; Aged; Atrophy; Candida albicans; Candidiasis, Oral; Cheilitis; Chronic Disease; Denture, Complete, Upper; Drug Resistance, Microbial; Female; Humans; Male; Middle Aged; Nystatin; Stomatitis; Stomatitis, Denture; Tablets

Chronic candidiasis of the oral cavity and esophagus may present with a varying clinical picture. Three cases of this entity are presented. Infection occurs when the ecologic balance of normal flora and local factors are upset. Predisposing factors are listed. The different presentations, methods of evaluation, diagnosis, treatment alternatives, and immunologic applications are discussed. The problems of the chronic form of the disease, with it becoming deeply ingrained and recurrent, are stressed.

Topics: Candidiasis, Oral; Chronic Disease; Esophageal Diseases; Female; Humans; Middle Aged; Nystatin

Many patients with oral candidiasis respond very slowly or not at all to therapy with amphotericin. Strains of Candida albicans were collected from 17 patients clinically resistant and from 15 who responded to a normal course of amphotericin treatment. Minimal inhibitory concentrations (MIC) determined on diagnostic sensitivity test agar plates gave values of: amphotericin 0-5 mg/l; nystatin 50 i.u./ml; chlorhexidine 12.5 mg/l. No clear MIC could be determined with plates containing miconazole. No difference was noted in MIC values between the 2 groups of patients. Tube-dilution tests in Sabouraud's broth gave MIC values of: amphotericin 0.25 mg/l; nystatin 12.5 i.u./ml; chlorhexidine 1.5 mg/l; miconazole 8-32 mg/l; ketonazole 64 mg/l. Persistence of oral candidiasis is not an indication of infection with resistant organisms. Despite difficulties in in vitro sensitivity testing of miconazole a clinical trial of the drug for treating oral candidiasis is indicated.

Topics: Amphotericin B; Antifungal Agents; Candida albicans; Candidiasis, Oral; Chlorhexidine; Chronic Disease; Drug Resistance, Microbial; Humans; Miconazole; Microbial Sensitivity Tests; Nystatin

Topics: Chronic Disease; Female; Humans; Nystatin; Ointments; Paronychia

A positive microbiological evidence could be obtained 54 times from the smear of the exterior genitals of 80 women suffering from complaints that were caused by urethritis, criteria of the examinations being sterile catheter specimen, negative cystoscopical findings, and missing indications to anatomical changes in the urethral region. Cytological examinations of these cases with regard to the vaginal epithelium had the following results:Group I:6 times; group II: 37 times; group IIW:8 times; group IIId: once; group IVa:twice. The cytological tests were carried out according to the method of papanicolaou as modified by Soost. Furthermore, we could state the following degrees of purity: Degree I: 8 times; degree II:16 times; degree III: 30 times. The cytological examinations of the urethral epithelium demonstrated, in 52 cases, an increased appearance of "nude" completely exposed epithelial cell nuclei--a fact corresponding to a degenerative autolysis (according to Wied). In the 26 women with missing atypical germ flora within the region of the exterior genitals, exclusively groups I (according to Papanicolaou and Soost) and degrees of purity I were stated. These persons also demonstrated remarkably grave psychical disturbances, especially in the intimate regions. In the cases of positive microbiological evidence, the following measures have proved satisfactory: Vaginal hygienization combined with a directly aimed antibacterial therapy, and the prescription of preparations containing lactic acid. A transitory discontinuation of contraceptives is being discussed. Our examination results are emphasizing the necessity of an analysis of the germ flora in cases of complaints arising from urethritis. Also psychical disturbances must be taken into consideration in cases of missing urological and gynaecological criteria of evidence.

Topics: Candidiasis, Vulvovaginal; Cervix Uteri; Chronic Disease; Female; Humans; Male; Metronidazole; Mycoplasma Infections; Nystatin; Psychophysiologic Disorders; Tetracycline; Trichomonas Vaginitis; Urethra; Urethritis; Vagina; Vaginal Diseases

Topics: Acute Disease; Aminophylline; Anti-Bacterial Agents; Blood Coagulation; Body Temperature; Chronic Disease; Erythromycin; Furosemide; Heparin; Humans; Nikethamide; Nystatin; Oleandomycin; Penicillins; Peptide Hydrolases; Physical Therapy Modalities; Plasma Substitutes; Pneumonia; Pneumonia, Staphylococcal; Streptomycin; Strophanthins; Sulfadimethoxine; Sulfanilamides; Tetracycline; Vitamins

Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis, Cutaneous; Candidiasis, Oral; Child; Chronic Disease; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Female; Flucytosine; Fluorouracil; Humans; Hypersensitivity, Delayed; Immunologic Deficiency Syndromes; Immunotherapy; Lymphocyte Activation; Microbial Sensitivity Tests; Nystatin; Skin Diseases; Staphylococcal Infections

Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Drug Combinations; Female; Gramicidin; Humans; Hypersensitivity; Male; Middle Aged; Neomycin; Nystatin; Ointments; Skin Diseases; Triamcinolone Acetonide

A 36-year-old female was admitted to hospital for debridement of chronically inflamed tendon sheaths and adjacent tissues near the left ankle. Despite antibiotic therapy and initial surgical interventions, the inflammation had progressed slowly over 16 months. Histopathological examination of excised tissues in September 1973 revealed a chronic granulomatous inflammation of tendon sheaths and muscle. Many branched hyphal segments, intercalary swollen cells, and a few conidia-like bodies were seen in sections, and also in KOH- and PAS-stained slides prepared from homogenized tissues. Culture of homogenized tissues yielded pure colonies of Scopulariopsis brevicaulis. Sensitivity tests were initially begun with amphotericin B, potassium iodide, and potassium tartrate (0.05-15 mug/ml of the phytone-yeast extract agar), and no inhibitory effect was observed. Subsequently, amphotericin B, antimony, 5-fluorocytosine (5-FC), griseofulvin, hamycin, and mycostatin were tested (25-300 mug/ml of the phytone-yeast extract agar). Of these chemicals, griseofulvin and hamycin proved to be most effective. Antimony and 5-FC were ineffective, and mycostatin produced a negligible effect on growth. The four strains of Lysobacter antibioticus, the producer of myxin antibiotic, strongly inhibited the growth of the fungus.

Topics: Adult; Amphotericin B; Ankle Joint; Antimony; Chronic Disease; Female; Flucytosine; Granulation Tissue; Griseofulvin; Humans; Microbial Sensitivity Tests; Mitosporic Fungi; Mycoses; Natamycin; Nystatin; Potassium Iodide; Staining and Labeling; Tartrates; Tendinopathy

Topics: Amphotericin B; Chronic Disease; Humans; Natamycin; Nystatin; Pharyngitis

A guest faculty discussed the management of patients with vaginal infections. It was agreed that correct diagnosis is necessary before therapy. Diagnosis can be accomplished by a microscopic examination in 90% of the cases. The cytologic smear is also very important. Specific culture media may be useful for troublesome cases, for instance, blood agar fo Haemophilus vaginalis, Trichocel medium for Trichiomonas vaginalis, Neckerson's medium for candidal species and Thayer-Martin for Neisseria gonorrhoeae. Patient history is important since some infections tend to occur in certain patients such as candidiasis in patients with diabetes mellitus, patients who are pregnant or are taking broad spectrum antibiotics, estrogen or contraceptive pills. The pH of vaginal secretions may also be helpful in making the diagnosis. It was suggested that the term "nonspecific" vaginitis is a misnomer and is used to conceal ignorance. Others felt that such agents as soap, vaginal deodorant spray, and clothing may be causatives. The term "psychogenic leukorrhea" was discussed with varying conclusions. Routine treatment for each form of vaginitis was outlines and treatment for recurrent, persistent trichomoniasis and moniliasis was given. It was agreed that douching will not cure vaginitis but may be useful in removing excessive secretion. It is not recommended for routine hygeine but is acceptable following menstruation or intercourse.

Topics: Adult; Candidiasis, Vulvovaginal; Child; Chronic Disease; Clioquinol; Estrogens, Conjugated (USP); Female; Haemophilus Infections; Humans; Leukorrhea; Metronidazole; Nitrofurazone; Nystatin; Pregnancy; Sulfates; Therapeutic Irrigation; Trichomonas Vaginitis; Vagina; Vaginal Smears; Vaginitis

Topics: Aged; Anti-Bacterial Agents; Candidiasis; Carcinoma, Squamous Cell; Chronic Disease; Corneal Transplantation; Corneal Ulcer; Eyelid Neoplasms; Female; Glucocorticoids; Humans; Keratitis; Male; Nystatin; Radiation Injuries; Transplantation, Homologous

Topics: Adolescent; Adult; Aged; Allergens; Angioedema; Candida albicans; Candidiasis; Child; Chronic Disease; Desensitization, Immunologic; Female; Humans; Hypersensitivity; Male; Middle Aged; Nystatin; Urticaria

Topics: Aged; Amphotericin B; Antigens; Candidiasis, Cutaneous; Chronic Disease; Cobalt Isotopes; Female; Humans; Immunity, Cellular; Lectins; Lymphocytes; Mediastinal Neoplasms; Nystatin; Skin Tests; Thymoma

Topics: Acrodermatitis; Adult; Candidiasis, Cutaneous; Chronic Disease; Humans; Hypersensitivity; Male; Middle Aged; Nystatin

Topics: Adult; Chronic Disease; Female; Histoplasma; Histoplasmosis; Humans; Nystatin

Topics: Aged; Ampicillin; Chronic Disease; Drug Synergism; Haemophilus influenzae; Humans; Lung Diseases, Obstructive; Male; Nystatin; Pneumonia; Sputum; Sulfonamides; Tetracycline; Trimethoprim

Topics: Adult; Amphotericin B; Antigens; Candida; Candidiasis; Chronic Disease; Female; Food Hypersensitivity; Humans; Hypersensitivity; Immunoglobulin E; Male; Nystatin; Saccharomyces; Skin Tests; Urticaria

Topics: Acute Disease; Candida; Chronic Disease; Humans; Nystatin; Paronychia

Topics: Abdominal Muscles; Abscess; Adult; Candidiasis; Cellulitis; Chloramphenicol; Chronic Disease; Enterobacteriaceae; Female; Gastrointestinal Diseases; Humans; Liver Abscess; Male; Middle Aged; Nystatin; Retroperitoneal Space; Staphylococcus; Streptococcus pyogenes; Therapeutic Irrigation

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Arachnoiditis; Brain Abscess; Child; Child, Preschool; Chronic Disease; Female; Humans; Infant; Male; Meningitis; Middle Aged; Nystatin; Osteomyelitis; Polysaccharides, Bacterial; Serratia marcescens; Spinal Cord Diseases; Streptomycin

Topics: Amphotericin B; Chronic Disease; Contact Lenses; Corneal Transplantation; Corneal Ulcer; Epithelium; Female; Humans; Idoxuridine; Keratitis, Dendritic; Keratoconjunctivitis; Male; Middle Aged; Mycoses; Nystatin; Sjogren's Syndrome; Transplantation, Homologous

A 35-year-old man with idiopathic hypoparathyroidism and moniliasis developed progressive dysphagia and weight loss. Diagnostic studies established the presence of esophageal moniliasis. Therapy with a viscous suspension of nystatin resulted in rapid clinical improvement; prolonged administration of the drug was associated with progressive widening of a narrowed segment of esophagus and complete disappearance of dysphagia. The chemotherapy of esophageal moniliasis is discussed in the light of current knowledge of the pharmacological action of nystatin.

Topics: Administration, Oral; Adult; Candidiasis; Chronic Disease; Deglutition Disorders; Esophageal Diseases; Esophagus; Humans; Male; Nystatin; Radiography; Suspensions; Viscosity

Topics: Acute Disease; Adult; Aged; Candidiasis, Oral; Chronic Disease; Female; Gentian Violet; Humans; Male; Middle Aged; Nystatin; Retrospective Studies

Topics: Candida; Candidiasis, Vulvovaginal; Chronic Disease; Drug Resistance, Microbial; Female; Humans; Nystatin

Topics: Candidiasis; Child; Chronic Disease; Diagnosis, Differential; Esophagitis; Fluoroscopy; Geriatrics; Humans; Nystatin; Respiratory Tract Diseases