nystatin-a1 and Carcinoma--Squamous-Cell

Oral lichen planus is a mucosal inflammatory disease whose pathogenesis is unclear. The chronic inflammation leads to development of a squamous cell carcinoma in 1-2% of the patients; we present an exemplary case.

Topics: Administration, Oral; Amphotericin B; Antifungal Agents; Carcinoma, Squamous Cell; Humans; Lichen Planus, Oral; Male; Middle Aged; Nystatin; Skin Neoplasms; Treatment Outcome

Oral candidiasis is a significant problem in immune-compromised patients. The most common forms of mucosal candidiasis are oropharyngeal, oesophageal and vaginal, and more than 90% of HIV positive persons will manifest at least one episode of oropharyngeal candidiasis. Local and systemic factors such as uninterrupted daily use of a prosthesis by patients, smoking habit, as well as high glucose intake may contribute to the development of the lesion. The aim of this article is to report an uncommon case of oral candidiasis presenting an aggressive clinical behaviour in a 64-year-old male patient, with a significant smoking habit and a medical history of non-controlled diabetes. The lesion affected the hard and soft palate of the right side, revealing erythematous and ulcerated areas, elevated borders and central portions resembling necrosis, mimicking the clinical features of oral squamous cell carcinoma. However, the correct diagnosis of oral candidiasis was obtained after histopathological and cytological examinations and the patient was easily treated with traditional antifungal drugs and correction of his glucose levels.

Topics: Antifungal Agents; Candidiasis, Oral; Carcinoma, Squamous Cell; Diabetes Complications; Diagnosis, Differential; Humans; Male; Middle Aged; Nystatin; Palatal Neoplasms

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive disease caused by mutations in the AIRE gene. We report the case of a female patient with a 967-979del13 mutation in the AIRE gene. Her medical history included autoimmune hypoparathyroidism, Addison disease, and chronic mucocutaneous candidiasis. At the age of 40, she developed multiple white verrucous plaques on the oral mucosa. Histologically, the lesions appeared as moderately differentiated squamous cell carcinomas. The patient subsequently developed multiple local recurrences and therefore required repeated surgery. Notably, a higher incidence rate of oral and esophageal squamous cell carcinoma has been observed in this syndrome. However, the critical pathogenetic pathways implicated in squamous cell carcinoma development in APECED are far from being well understood.

Topics: Adult; Amphotericin B; Antifungal Agents; Candidiasis, Chronic Mucocutaneous; Carcinoma, Squamous Cell; Female; Humans; Nystatin; Polyendocrinopathies, Autoimmune

A candidal abscess is a known complication of disseminated candidiasis, particularly in immunocompromised patients. We report a second primary growth in the neopharynx brought to light by a candidal abscess in a non-immunocompromised patient.

Topics: Antifungal Agents; Candidiasis; Carcinoma, Squamous Cell; Fluconazole; Humans; Male; Middle Aged; Neoplasms, Second Primary; Nystatin; Pharyngeal Neoplasms; Retropharyngeal Abscess; Treatment Outcome

Upper airway obstruction is always a serious condition. In patients who have previously been irradiated for a laryngeal malignancy, it normally implies either residual or recurrent disease. We report a case of stridor due to invasive laryngeal candidiasis in a patient who had undergone radiotherapy for a T1a N0 squamous cell carcinoma of the glottis eight months earlier. Extensive investigation failed to identify recurrence of disease and the patient responded to prolonged topical antifungal therapy. Infection with Candida species is most frequently found in debilitated or immunocompromised patients. Although cases of upper airway obstruction in children secondary to idiopathic laryngeal candidiasis have been reported, to our knowledge no such presentation has been described in adults. This report highlights the difficulty of diagnosis and treatment. Familiarity with candidal infection is important for early diagnosis and appropriate treatment.

Topics: Administration, Topical; Aged; Antifungal Agents; Candidiasis; Carcinoma, Squamous Cell; Humans; Laryngeal Diseases; Laryngeal Neoplasms; Laryngoscopy; Male; Nystatin; Radiotherapy; Respiratory Sounds

Therapeutic application of immunoglobulin is reported to be successful in radiation-induced oral and oropharyngeal mucositis. In this study the efficacy of prophylactic application of immunoglobulin was investigated. In 42 patients with head and neck cancer, postoperative radiation treatment or radiation combined with chemotherapy was performed. In 20 consecutive patients, prophylactic mucositis treatment consisted of panthenol (4 x 10 ml/day) and nystatin (4 x 1 ml/day). The 22 following patients received, supplementary to panthenol and nystatin, 800 mg (5 ml) human immunoglobulin intramuscularly once weekly. During the treatment time, the degree of mucositis was examined 3 times a week. The distribution of maximal mucositis degree revealed slightly more severe mucous membrane reaction in the control group compared with the immunoglobulin group (n.s.). The analysis of mean mucositis degrees in both groups demonstrated statistically significant differences (t test, p = 0.031) related to the entire group (n = 42) and to those 16 patients receiving radiation combined with chemotherapy. There was no significant immunoglobulin-induced effect on mucositis in patients treated by radiation alone. The time from the beginning of therapy to the first interruption could be prolonged 5 days in the immunoglobulin group (n.s.). In conclusion, it is demonstrated that the prophylactic application of immunoglobulin seems to lower the degree of radiation-induced mucositis. In comparison to the published data about therapeutically given immunoglobulin, the clinical efficacy of the prophylactic application of immunoglobulin as it is performed in this study is less evident.

Topics: Adult; Aged; Anti-Bacterial Agents; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Immunization, Passive; Immunoglobulins; Injections, Intramuscular; Laryngeal Neoplasms; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Mouthwashes; Nystatin; Oropharynx; Pantothenic Acid; Pharyngeal Neoplasms; Pharyngitis; Radiation Injuries; Radiotherapy; Stomatitis

Topics: Aged; Anti-Bacterial Agents; Candidiasis; Carcinoma, Squamous Cell; Chronic Disease; Corneal Transplantation; Corneal Ulcer; Eyelid Neoplasms; Female; Glucocorticoids; Humans; Keratitis; Male; Nystatin; Radiation Injuries; Transplantation, Homologous

Topics: Abortion, Septic; Adult; Amphotericin B; Anti-Bacterial Agents; Candida; Candidiasis; Carcinoma, Squamous Cell; Female; Genital Diseases, Female; Humans; Immunosuppressive Agents; Middle Aged; Nystatin; Postoperative Complications; Pregnancy; Uterine Cervical Neoplasms