nystatin-a1 and Asthma

Sixty-seven asthmatic individuals treated with either beclomethasone diproprionate or flunisolide were sequentially evaluated for up to 32 months to determine the incidence of oropharyngeal candidiasis as well as laboratory parameters which might be predictive of this complication. Throat cultures and measurements of Candida antibody by immunodiffusion and radioimmunoassay were performed and compared over time and treatment groups. Unlike other studies, pre-treatment Candida precipitins did not predict increased risk for clinical thrush nor did quantitative determinations of Candida antibody. Those patients with positive cultures pre-trial, however, had a significantly higher incidence of clinical thrush than those with negative cultures (P less than 0.01). No significant changes occurred over time or between drugs for any of the parameters. Symptomatic thrush, however, was slightly more common in those patients treated with beclomethasone.

Topics: Adolescent; Adult; Aerosols; Aged; Antibodies, Fungal; Asthma; Beclomethasone; Binding Sites, Antibody; Candida; Candidiasis, Oral; Female; Fluocinolone Acetonide; Humans; Male; Middle Aged; Nystatin; Risk

Topics: Adrenal Cortex Hormones; Aerosols; Asthma; Beclomethasone; Candidiasis; Candidiasis, Oral; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nystatin; Respiratory Tract Infections; Time Factors; Voice Disorders

Topics: Administration, Oral; Administration, Topical; Aerosols; Anti-Inflammatory Agents; Asthma; Beclomethasone; Candidiasis; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; Glucocorticoids; Humans; Methylprednisolone; Mouth Diseases; Mouth Mucosa; Nystatin; Pharyngeal Diseases; Placebos; Prednisone; Propionates

To determine clinical variables to distinguish invasive pulmonary aspergillosis (IPA) from colonization in patients with chronic pneumopathies with positive culture of Aspergillus spp. in respiratory samples.. Retrospective cohort study including patients with respiratory isolations of Aspergillus spp. during a period of 10 years. IPA was evaluated according to the Bulpa criteria. Clinical variables were collected and a multiple logistic regression analysis was carried out.. Eighty-three patients with isolation of Aspergillus spp. from respiratory samples were included; 68.7% (n=57) of the patients had chronic obstructive pulmonary disease, 18% (n=15) pulmonary fibrosis and 13.3% (n=11) bronchial asthma. Twenty-two patients (26.6%) had IPA. The use of fluconazole (OR 4.49; CI 95% 1.5-13.4; P=.007), severe respiratory failure (OR 4.64; CI 95% 1.46-14.72; P=.009) and hospitalization time (OR 1.05; CI 95% 1.01-1.1; P=.006) were associated with IPA.. Prior use of fluconazole, severe respiratory failure and hospitalization time are associated with IPA in patients with chronic pneumopathies with respiratory isolation of Aspergillus spp.

Topics: Aged; Aged, 80 and over; Antifungal Agents; Aspergillus; Asthma; Bacterial Infections; Carrier State; Chronic Disease; Comorbidity; Cross Infection; Diagnosis, Differential; Disease Susceptibility; Female; Fluconazole; Hospitals, University; Humans; Incidence; Invasive Pulmonary Aspergillosis; Length of Stay; Lung; Lung Diseases; Male; Middle Aged; Nystatin; Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis; Respiratory Insufficiency; Retrospective Studies; Risk Factors; Spain

Topics: Administration, Inhalation; Aged; Amphotericin B; Anti-Asthmatic Agents; Asthma; Candidemia; Candidiasis, Oral; Drug Therapy, Combination; Endophthalmitis; Eye Infections, Fungal; Female; Fluconazole; Glucocorticoids; Humans; Nystatin; Risk Factors

Topics: Antifungal Agents; Asthma; Betamethasone; Candidiasis, Oral; HIV Seronegativity; Humans; Ketoconazole; Leukoplakia, Hairy; Male; Middle Aged; Nystatin

Topics: Aspergillosis; Asthma; Humans; Lung Diseases, Fungal; Male; Middle Aged; Nystatin

Topics: Anti-Infective Agents, Local; Antifungal Agents; Asthma; Bronchitis; Candida; Candidiasis; Child; Culture Techniques; Drug Resistance, Microbial; Fibroblasts; HeLa Cells; Humans; Lung Diseases, Fungal; Nystatin; Pneumonia; Quinolines; Respiratory Tract Infections

Topics: Adrenal Cortex Hormones; Asthma; Candidiasis; Candidiasis, Oral; Humans; Nystatin; Toxicology; Triamcinolone