nystatin-a1 and Arthritis

The effects of aqueous and alkaline extracts from Agaricus blazei Murill, an edible mushroom used as folk medicine in Brazil, Japan, and China to treat several illnesses, were investigated on the basis of the inflammatory process induced by different agents. Oral administration of A. blazei extracts marginally inhibited the edema induced by nystatin. In contrast, when complete Freund's adjuvant was used as the inflammatory stimulus, both extracts were able to inhibit this process significantly (P < .05, analysis of variance followed by Tukey-Kramer multiple comparison post hoc test), although it inhibited the granulomatous tissue induction moderately. These extracts were able to decrease the ulcer wounds induced by stress. Also, administration of extracts inhibited neutrophil migration to the exudates present in the peritoneal cavity after carrageenin injection. Therefore, it is possible that A. blazei extracts can be useful in inflammatory diseases because of activation of the immune system and its cells induced by the presence of polysaccharides such as beta-glucans.

Topics: Adjuvants, Immunologic; Agaricus; Analysis of Variance; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Arthritis; Carrageenan; Disease Models, Animal; Edema; Freund's Adjuvant; Granuloma; Male; Neutrophil Infiltration; Nystatin; Plant Extracts; Rats; Rats, Wistar; Stomach Ulcer

Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Carrageenan; Copper; Edema; Inflammation; Mycobacterium tuberculosis; Nystatin; Rats

Cyclophosphamide (5 or 10 mg/kg p.o.) and Gold sodium thiomalate (0 or 40 mg/kg i.m.) inhibit after repeated administrations (5 days) all the phases of Nystatin edema, whereas a single administration is ineffective. D-Penicillamine (25 or 100 mg/kg p.9.) inhibits the early phases of Nystatin edema after a single administration whereas repeated administrations are almost ineffective. An early treatment with Cyclophosphamide (2.5 mg/kg p.o.) simply delays the appearance of the secondary lesions of adjuvant arthritis but inhibit the development of the primary lesions. A late treatment with Cyclophosphamide as both the types of treatment with Gold sodium thiomalate (10 mg/kg i.m.) are effective against primary and secondary lesions. The only effect of D-Penicillamine (50 mg/kg p.o.) in adjuvant arthritis is a significant increase of the intensity of secondary lesions during the late treatment. It is suggested that the anti-inflammatory activity of Cyclophosphamide does not depend exclusively upon its immunosuppressant activity and that D-Penicillamine is effective on some cell population committed in the inflammatory reactions.

Topics: Animals; Arthritis; Arthritis, Experimental; Cyclophosphamide; Disease Models, Animal; Female; Gold Sodium Thiomalate; Inflammation; Nystatin; Penicillamine; Rats; Time Factors

Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Chloramphenicol; Cyclophosphamide; Dexamethasone; Drug Antagonism; Edema; Hydrocortisone; Immunosuppressive Agents; Indomethacin; Inflammation; Male; Mefenamic Acid; Mercaptopurine; Nystatin; Phenylacetates; Phenylbutazone; Prednisolone; Rats; Rifampin; Triamcinolone

Topics: Animals; Arthritis; Forelimb; Guinea Pigs; Injections, Intra-Articular; Methods; Nystatin; Radiometry; Radionuclide Imaging; Serum Albumin, Radio-Iodinated; Synovitis

Topics: Amphotericin B; Animals; Antifungal Agents; Arthritis; Cartilage, Articular; Drug Eruptions; In Vitro Techniques; Injections, Intra-Arterial; Injections, Intradermal; Lysosomes; Mitochondria; Nystatin; Rabbits; Synovial Membrane