nutlin-3a and Carcinoma--Mucoepidermoid

nutlin-3a has been researched along with Carcinoma--Mucoepidermoid* in 1 studies

Other Studies

1 other study(ies) available for nutlin-3a and Carcinoma--Mucoepidermoid

Article	Year
Mycoplasma hyorhinis reduces sensitivity of human lung carcinoma cells to Nutlin-3 and promotes their malignant phenotype. Journal of cancer research and clinical oncology, 2018, Volume: 144, Issue:7 MDM2 inhibitors are promising anticancer agents that induce cell cycle arrest and tumor cells death via p53 reactivation. We examined the influence of Mycoplasma hyorhinis infection on sensitivity of human lung carcinoma cells NCI-H292 to MDM2 inhibitor Nutlin-3. In order to unveil possible mechanisms underlying the revealed effect, we investigated gene expression changes and signal transduction networks activated in NCI-H292 cells in response to mycoplasma infection.. Sensitivity of NCI-Н292 cells to Nutlin-3 was estimated by resazurin-based cell viability assay. Genome-wide transcriptional profiles of NCI-H292 and NCI-Н292. NCI-Н292. Our results provide evidence that mycoplasma infection is an important factor modulating the effect of MDM2 inhibitors on cancer cells and is able to induce EMT-related changes. Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Mucoepidermoid; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Imidazoles; Lung Neoplasms; Male; Middle Aged; Mycoplasma hyorhinis; Mycoplasma Infections; Piperazines; Signal Transduction; Transcriptome; Young Adult	2018

Article

Year

Mycoplasma hyorhinis reduces sensitivity of human lung carcinoma cells to Nutlin-3 and promotes their malignant phenotype.

Journal of cancer research and clinical oncology, 2018, Volume: 144, Issue:7

MDM2 inhibitors are promising anticancer agents that induce cell cycle arrest and tumor cells death via p53 reactivation. We examined the influence of Mycoplasma hyorhinis infection on sensitivity of human lung carcinoma cells NCI-H292 to MDM2 inhibitor Nutlin-3. In order to unveil possible mechanisms underlying the revealed effect, we investigated gene expression changes and signal transduction networks activated in NCI-H292 cells in response to mycoplasma infection.. Sensitivity of NCI-Н292 cells to Nutlin-3 was estimated by resazurin-based cell viability assay. Genome-wide transcriptional profiles of NCI-H292 and NCI-Н292. NCI-Н292. Our results provide evidence that mycoplasma infection is an important factor modulating the effect of MDM2 inhibitors on cancer cells and is able to induce EMT-related changes.

Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Mucoepidermoid; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Imidazoles; Lung Neoplasms; Male; Middle Aged; Mycoplasma hyorhinis; Mycoplasma Infections; Piperazines; Signal Transduction; Transcriptome; Young Adult

2018