nsc185058 has been researched along with Ulcer* in 1 studies
1 other study(ies) available for nsc185058 and Ulcer
| Article | Year |
|---|---|
N-phenyl-2-pyridinecarbothioamides as gastric mucosal protectants.
A series of substituted 2-pyridinecarbothioamides was synthesized and evaluated for gastric mucosal protectant activity in the rat. Out of this investigation N-(3,5-difluorophenyl)-2- pyridinecarbothioamide (23, AY-31,574) was identified. This compound was much more potent than sucralfate and ranitidine against ethanol-induced lesions. Compound 23 was equipotent with ranitidine against gastric injury caused by stress. Unlike ranitidine, 23 was found to be devoid of antisecretory activity in the pylorus-ligated rat model, making it a selective mucosal protectant. Such a potent selective mucosal protectant may provide a novel clinical approach in treating ulcers. Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Ethanol; Fluorobenzenes; Gastric Acid; Gastric Mucosa; Molecular Structure; Pyridines; Ranitidine; Rats; Stress, Physiological; Structure-Activity Relationship; Sucralfate; Thioamides; Ulcer | 1990 |