nsc-83265 and Leukemia--Myelogenous--Chronic--BCR-ABL-Positive

nsc-83265 has been researched along with Leukemia--Myelogenous--Chronic--BCR-ABL-Positive* in 1 studies

Other Studies

1 other study(ies) available for nsc-83265 and Leukemia--Myelogenous--Chronic--BCR-ABL-Positive

Article	Year
S-trityl-L-cysteine derivative induces caspase-independent cell death in K562 human chronic myeloid leukemia cell line. Cancer letters, 2010, Dec-01, Volume: 298, Issue:1 Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-BP1. The wide ranging caspase inhibitor z-VAD fmk prevented the cleavage of caspase-3 and 4E-BP1, but failed to attenuate PARP-1 cleavage or cell death triggered by CF(3)-STLC. These results suggest that CF(3)-STLC can induce apoptotic cell death in a caspase-independent manner, and may work effectively as an anti-cancer agent for hematological malignancies. Topics: Apoptosis; Caspases; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Cysteine; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive	2010

Article

Year

S-trityl-L-cysteine derivative induces caspase-independent cell death in K562 human chronic myeloid leukemia cell line.

Cancer letters, 2010, Dec-01, Volume: 298, Issue:1

Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-BP1. The wide ranging caspase inhibitor z-VAD fmk prevented the cleavage of caspase-3 and 4E-BP1, but failed to attenuate PARP-1 cleavage or cell death triggered by CF(3)-STLC. These results suggest that CF(3)-STLC can induce apoptotic cell death in a caspase-independent manner, and may work effectively as an anti-cancer agent for hematological malignancies.

Topics: Apoptosis; Caspases; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Cysteine; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive

2010