nsc-716970 and Melanoma

nsc-716970 has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for nsc-716970 and Melanoma

Article	Year
A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation. Bioorganic & medicinal chemistry, 2010, Jul-15, Volume: 18, Issue:14 The synthesis of an achiral seco-hydroxy-aza-CBI-TMI analog (8) of the duocarmycins is reported. Its specificity for the DNA minor groove of AT-rich sequences and covalent bonding to adenine-N3 was ascertained by a thermal cleavage assay. Compound 8 was found to be cytotoxic in the nanomolar range against murine and human cancer cells. It was further demonstrated that compound 8 was active against murine melanoma (B16-F0) grown in C57BL/6 mice. Compound 8 was also shown to inhibit the growth of the protozoan parasites Leishmania donovani, Leishmania mexicana, Trypanosoma brucei, and Plasmodium falciparum in culture. Topics: Animals; Antibiotics, Antineoplastic; Antiprotozoal Agents; Cell Line, Tumor; DNA; Drug Screening Assays, Antitumor; Duocarmycins; Female; Humans; Indoles; Melanoma; Mice; Mice, Inbred C57BL; Parasitic Sensitivity Tests; Pyrrolidinones	2010

Article

Year

A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation.

Bioorganic & medicinal chemistry, 2010, Jul-15, Volume: 18, Issue:14

The synthesis of an achiral seco-hydroxy-aza-CBI-TMI analog (8) of the duocarmycins is reported. Its specificity for the DNA minor groove of AT-rich sequences and covalent bonding to adenine-N3 was ascertained by a thermal cleavage assay. Compound 8 was found to be cytotoxic in the nanomolar range against murine and human cancer cells. It was further demonstrated that compound 8 was active against murine melanoma (B16-F0) grown in C57BL/6 mice. Compound 8 was also shown to inhibit the growth of the protozoan parasites Leishmania donovani, Leishmania mexicana, Trypanosoma brucei, and Plasmodium falciparum in culture.

Topics: Animals; Antibiotics, Antineoplastic; Antiprotozoal Agents; Cell Line, Tumor; DNA; Drug Screening Assays, Antitumor; Duocarmycins; Female; Humans; Indoles; Melanoma; Mice; Mice, Inbred C57BL; Parasitic Sensitivity Tests; Pyrrolidinones

2010