nsc-706744 has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for nsc-706744 and Breast-Neoplasms
| Article | Year |
|---|---|
Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
DNA topoisomerase IB (TOP1) regulates DNA topological structure in many cellular metabolic processes and is a validated target for development of antitumor agents. Our previous study revealed that the benzophenanthridone scaffold is a novel chemotype for the discovery of TOP1 inhibitors. In this work, a series of novel 5-aminoethyl substituted benzophenanthridone derivatives have been synthesized and evaluated for TOP1 inhibition and cytotoxicity. Compound 12 exhibits the most potent TOP1 inhibition (+++) and cytotoxicity in human cancer cell lines with GI Topics: Animals; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Breast Neoplasms; Cell Line, Tumor; DNA Damage; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Mice, Nude; Molecular Docking Simulation; Molecular Structure; Protein Binding; Structure-Activity Relationship; Topoisomerase I Inhibitors; Xenograft Model Antitumor Assays | 2019 |