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nsc 664704 and Alzheimer Disease

nsc 664704 has been researched along with Alzheimer Disease in 2 studies

kenpaullone: inhibits CDK1/cyclin B; structure in first source
kenpaullone : An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta).

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research Excerpts

ExcerptRelevanceReference
"Indirubins were recently described as potent (IC(50): 50-100 nm) inhibitors of cyclin-dependent kinases (CDKs)."1.31Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? ( Bibb, JA; Biernat, J; Eisenbrand, G; Garnier, M; Greengard, P; Hoessel, R; Leclerc, S; Mandelkow, EM; Marko, D; Meijer, L; Snyder, GL; Wu, YZ, 2001)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leost, M1
Schultz, C1
Link, A1
Wu, YZ2
Biernat, J2
Mandelkow, EM2
Bibb, JA2
Snyder, GL2
Greengard, P2
Zaharevitz, DW1
Gussio, R1
Senderowicz, AM1
Sausville, EA1
Kunick, C1
Meijer, L2
Leclerc, S1
Garnier, M1
Hoessel, R1
Marko, D1
Eisenbrand, G1

Other Studies

2 other studies available for nsc 664704 and Alzheimer Disease

ArticleYear
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.
    European journal of biochemistry, 2000, Volume: 267, Issue:19

    Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Apoptosis; Benzazepines; Binding, Competitive; C

2000
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
    The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1

    Topics: Adenosine Triphosphate; Alkaloids; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Calcium-

2001