nsc-4347 has been researched along with Pneumonia--Viral* in 1 studies
1 other study(ies) available for nsc-4347 and Pneumonia--Viral
| Article | Year |
|---|---|
Alkamides and Piperamides as Potential Antivirals against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
The pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has quickly spread globally, infecting millions and killing hundreds of thousands of people. Herein, to identify potential antiviral agents, 97 natural amide-like compounds known as alkamides and piperamides were tested against SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), and the human angiotensin-converting enzyme 2 (ACE2) using molecular docking and molecular dynamics simulations. The docking results showed that alkamides and dimeric piperamides from Topics: Amides; Angiotensin-Converting Enzyme 2; Antiviral Agents; Benzodioxoles; Betacoronavirus; Coronavirus 3C Proteases; Coronavirus Infections; COVID-19; Cysteine Endopeptidases; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Pandemics; Peptidyl-Dipeptidase A; Piper; Piperidines; Pneumonia, Viral; SARS-CoV-2; Viral Nonstructural Proteins | 2020 |