nsc-366140 and Leukemia-P388

nsc-366140 has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for nsc-366140 and Leukemia-P388

Article	Year
2-(aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines, a new class of anticancer agents. Journal of medicinal chemistry, 1992, Dec-25, Volume: 35, Issue:26 2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with [(alkylamino)alkyl]hydrazines. Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia. Advanced studies led to the selection of 3bbb for clinical trial. Topics: Acridines; Aminoacridines; Animals; Antineoplastic Agents; Cell Line; Humans; Leukemia L1210; Leukemia P388; Pyrazoles; Structure-Activity Relationship	1992

Article

Year

2-(aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines, a new class of anticancer agents.

Journal of medicinal chemistry, 1992, Dec-25, Volume: 35, Issue:26

2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with [(alkylamino)alkyl]hydrazines. Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia. Advanced studies led to the selection of 3bbb for clinical trial.

Topics: Acridines; Aminoacridines; Animals; Antineoplastic Agents; Cell Line; Humans; Leukemia L1210; Leukemia P388; Pyrazoles; Structure-Activity Relationship

1992