nsc-348103 has been researched along with Neoplasms* in 2 studies
2 other study(ies) available for nsc-348103 and Neoplasms
| Article | Year |
|---|---|
Synthesis and evaluation of anti-plasmodial and cytotoxic activities of epoxyazadiradione derivatives.
Epoxyazadiradione (1), a major compound derived from Neem oil, showed modest anti-plasmodial activity against CQ-resistant and CQ-sensitive strains of the most virulent human malaria parasite P. falciparum. A series of analogues were synthesized by modification of the key structural moieties of this high yield natural product. Out of the library of all compounds tested, compounds 3c and 3g have showed modest anti-plasmodial activity against CQ-sensitive (IC Topics: Animals; Antimalarials; Antineoplastic Agents; Azadirachta; Cell Line, Tumor; Cell Proliferation; Humans; Limonins; Malaria; Malaria, Falciparum; Mice; Mice, Inbred BALB C; Neoplasms; Plasmodium berghei; Plasmodium falciparum | 2017 |
Design, synthesis and docking studies of novel 1,2-dihydro-4-hydroxy-2-oxoquinoline-3-carboxamide derivatives as a potential anti-proliferative agents.
A new series of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide hybrids 8a-l have been designed and synthesized using peptide coupling agents with substituted N-phenyl piperazines and piperidines with good to excellent yields. The synthesized compounds were evaluated for their in vitro anti-proliferative activity against PANC 1, HeLa and MDA-MB-231. The compounds 8d, 8e, 8f, 8g, 8h and 8k exhibited considerable anti-proliferative activity with GI Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Docking Simulation; Neoplasms; Piperazines; Quinolones; Tubulin Modulators | 2017 |