nsc-141537 has been researched along with Brain-Neoplasms* in 2 studies
2 other study(ies) available for nsc-141537 and Brain-Neoplasms
| Article | Year |
|---|---|
Anguidine potentiates cis-platinum in human brain tumor cells.
Anguidine pretreatment was previously shown to potentiate cis-platinum in Chinese hamster ovary cells by 100-fold, probably by enhancing cellular cis-platinum uptake. Since both cis-platinum and anguidine have been reported to have clinical efficacy in human brain tumors, the present study was initiated to investigate whether anguidine's potentiation of cis-platinum was applicable to human brain tumor cells in culture. Using the colony formation assay, it was found that anguidine enhanced cis-platinum's cytotoxicity by ten-fold, producing a dose modification factor of 1.74. Alkaline elution analysis of cis-platinum-induced DNA cross-links found that anguidine enhanced cross-linking by a factor of 1.55, 1.76, 1.63, and 1.48 at 0, 6, 24, and 48 hr, respectively, after cis-platinum treatment. This enhancement of cross-linking is evidence for anguidine increasing cis-platinum uptake. Thus, anguidine enhances cis-platinum-induced DNA cross-linking and subsequent cytotoxicity in human brain tumor cells, and may be clinically useful in combination with cis-platinum in those tumors. Topics: Brain Neoplasms; Cell Survival; Cisplatin; DNA; Drug Synergism; Glioma; Humans; In Vitro Techniques; Sesquiterpenes; Time Factors; Trichothecenes | 1986 |
Phase II evaluation of anguidine in central nervous system tumors: a southwest Oncology Group study.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Drug Evaluation; Female; Humans; Male; Medulloblastoma; Middle Aged; Oligodendroglioma; Sesquiterpenes; Trichothecenes | 1983 |