nsc-106399 and Edema

nsc-106399 has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for nsc-106399 and Edema

Article	Year
Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 2011, Volume: 82, Issue:8 The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-γ increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS. Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Citrullus; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Inflammation; Interferon-gamma; Lipopolysaccharides; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phytotherapy; Plant Extracts; Reactive Nitrogen Species; Triterpenes	2011

Article

Year

Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition.

Fitoterapia, 2011, Volume: 82, Issue:8

The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-γ increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.

Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Citrullus; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Inflammation; Interferon-gamma; Lipopolysaccharides; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phytotherapy; Plant Extracts; Reactive Nitrogen Species; Triterpenes

2011