ns-1643 has been researched along with Triple-Negative-Breast-Neoplasms* in 2 studies
2 other study(ies) available for ns-1643 and Triple-Negative-Breast-Neoplasms
| Article | Year |
|---|---|
Pharmacological Activation of Potassium Channel Kv11.1 with NS1643 Attenuates Triple Negative Breast Cancer Cell Migration by Promoting the Dephosphorylation of Caveolin-1.
The prevention of metastasis is a central goal of cancer therapy. Caveolin-1 (Cav-1) is a structural membrane and scaffolding protein shown to be a key regulator of late-stage breast cancer metastasis. However, therapeutic strategies targeting Cav-1 are still lacking. Here, we demonstrate that the pharmacological activation of potassium channel Kv11.1, which is uniquely expressed in MDA-MB-231 triple negative breast cancer cells (TNBCs) but not in normal MCF-10A cells, induces the dephosphorylation of Cav-1 Tyr-14 by promoting the Ca Topics: beta Catenin; Caveolin 1; Cell Movement; Cresols; Humans; Phenylurea Compounds; Potassium Channels; Triple Negative Breast Neoplasms | 2022 |
Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling.
Topics: Animals; Antineoplastic Agents; beta Catenin; Cell Movement; Cell Proliferation; Cresols; Epithelial-Mesenchymal Transition; ERG1 Potassium Channel; Female; Humans; MCF-7 Cells; Mice; Neoplasm Metastasis; Phenylurea Compounds; Transplantation, Heterologous; Triple Negative Breast Neoplasms; Wnt Signaling Pathway | 2019 |