ns-1643 and Heart-Diseases

ns-1643 has been researched along with Heart-Diseases* in 1 studies

Other Studies

1 other study(ies) available for ns-1643 and Heart-Diseases

Article	Year
Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction. Cell proliferation, 2021, Volume: 54, Issue:2 Myocardial dysfunction is a significant manifestation in sepsis, which results in high mortality. Even Kcnh2 has been hinted to associate with the pathological process, its involved signalling is still elusive.. Kcnh2 plays a protection role in sepsis-induced cardiac dysfunction (SCID) via regulating FAK/AKT-FOXO3A to block LPS-induced myocardium apoptosis, indicating a potential effect of the potassium channels in pathophysiology of SCID. Topics: Animals; Apoptosis; Cresols; Down-Regulation; ERG1 Potassium Channel; Focal Adhesion Kinase 1; Forkhead Box Protein O3; Heart Diseases; Lipopolysaccharides; Male; Myocytes, Cardiac; Phenylurea Compounds; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rats, Transgenic; RNA Interference; RNA, Small Interfering; Sepsis; Signal Transduction; Survival Rate	2021

Article

Year

Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction.

Cell proliferation, 2021, Volume: 54, Issue:2

Myocardial dysfunction is a significant manifestation in sepsis, which results in high mortality. Even Kcnh2 has been hinted to associate with the pathological process, its involved signalling is still elusive.. Kcnh2 plays a protection role in sepsis-induced cardiac dysfunction (SCID) via regulating FAK/AKT-FOXO3A to block LPS-induced myocardium apoptosis, indicating a potential effect of the potassium channels in pathophysiology of SCID.

Topics: Animals; Apoptosis; Cresols; Down-Regulation; ERG1 Potassium Channel; Focal Adhesion Kinase 1; Forkhead Box Protein O3; Heart Diseases; Lipopolysaccharides; Male; Myocytes, Cardiac; Phenylurea Compounds; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rats, Transgenic; RNA Interference; RNA, Small Interfering; Sepsis; Signal Transduction; Survival Rate

2021