ns 1619 has been researched along with Muscle Contraction in 20 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Partial bladder outlet obstruction (PBOO) was surgically induced in male New Zealand White rabbits." | 1.36 | Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. ( Alanzi, J; Chacko, S; Chang, S; Gomes, CM; Hypolite, JA; Malkowicz, B; Marx, J; Wein, AJ; Zderic, SA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xin, F | 1 |
| Huang, H | 1 |
| Liu, P | 1 |
| Ren, J | 1 |
| Zhang, S | 1 |
| Cheng, Y | 1 |
| Wang, W | 1 |
| Wrzosek, A | 1 |
| Wang, Y | 1 |
| Zhang, HT | 1 |
| Su, XL | 1 |
| Deng, XL | 1 |
| Yuan, BX | 1 |
| Zhang, W | 1 |
| Wang, XF | 1 |
| Yang, YB | 1 |
| Chang, S | 2 |
| Gomes, CM | 1 |
| Hypolite, JA | 2 |
| Marx, J | 1 |
| Alanzi, J | 1 |
| Zderic, SA | 2 |
| Malkowicz, B | 1 |
| Wein, AJ | 2 |
| Chacko, S | 2 |
| Oger, S | 1 |
| Behr-Roussel, D | 1 |
| Gorny, D | 1 |
| Bernabé, J | 1 |
| Comperat, E | 1 |
| Chartier-Kastler, E | 1 |
| Denys, P | 1 |
| Giuliano, F | 1 |
| Soder, RP | 2 |
| Petkov, GV | 2 |
| Hristov, KL | 1 |
| Parajuli, SP | 1 |
| Cheng, Q | 1 |
| Rovner, ES | 1 |
| Lei, Q | 1 |
| Butler, S | 1 |
| Malykhina, AP | 1 |
| Tam, WY | 1 |
| Chen, ZY | 1 |
| He, ZD | 1 |
| Yao, X | 1 |
| Lau, CW | 3 |
| Huang, Y | 3 |
| Tanaka, Y | 2 |
| Horinouchi, T | 1 |
| Tanaka, H | 2 |
| Shigenobu, K | 2 |
| Koike, K | 2 |
| Edwards, G | 1 |
| Niederste-Hollenberg, A | 1 |
| Schneider, J | 1 |
| Noack, T | 1 |
| Weston, AH | 1 |
| Ho, IH | 1 |
| Geary, GG | 1 |
| Krause, DN | 1 |
| Duckles, SP | 1 |
| Corompt, E | 1 |
| Bessard, G | 1 |
| Lantuejoul, S | 1 |
| Naline, E | 1 |
| Advenier, C | 1 |
| Devillier, P | 1 |
| Patel, HJ | 1 |
| Giembycz, MA | 1 |
| Keeling, JE | 1 |
| Barnes, PJ | 1 |
| Belvisi, MG | 1 |
| Régrigny, O | 1 |
| Delagrange, P | 1 |
| Scalbert, E | 1 |
| Lartaud-Idjouadiene, I | 1 |
| Atkinson, J | 1 |
| Chillon, JM | 1 |
| Long, W | 1 |
| Zhang, L | 1 |
| Longo, LD | 1 |
| Imai, T | 1 |
| Okamoto, T | 1 |
| Yamamoto, Y | 1 |
| Spektor, M | 1 |
| Rodriguez, R | 1 |
| Rosenbaum, RS | 1 |
| Wang, HZ | 1 |
| Melman, A | 1 |
| Christ, GJ | 1 |
20 other studies available for ns 1619 and Muscle Contraction
| Article | Year |
|---|---|
Inhibition of ZERO-BK by PKC is involved in carbachol-induced enhancement of rat colon smooth muscle motility.
Topics: Animals; Benzimidazoles; Carbachol; Cholinergic Agonists; Colon; Gastrointestinal Motility; HEK293 C | 2018 |
The potassium channel opener NS1619 modulates calcium homeostasis in muscle cells by inhibiting SERCA.
Topics: Animals; Benzimidazoles; Calcium; Cell Line; Guinea Pigs; Homeostasis; Ischemia; Mice; Muscle Contra | 2014 |
Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance.
Topics: Animals; Benzimidazoles; Blood Glucose; Body Weight; Cerebral Arteries; Diabetes Mellitus, Experimen | 2010 |
Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein.
Topics: Aged; Aged, 80 and over; Animals; Benzimidazoles; Case-Control Studies; Cells, Cultured; Disease Mod | 2010 |
Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients.
Topics: Action Potentials; Adult; Aged; Apamin; Benzimidazoles; Case-Control Studies; Glyburide; Humans; In | 2011 |
Large conductance Ca2+ -activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle.
Topics: Animals; Benzimidazoles; Carbachol; Choline; Cholinergic Agonists; In Vitro Techniques; Ion Channel | 2011 |
Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large conductance Ca2+-activated K+ channels.
Topics: Aged; Aged, 80 and over; Benzimidazoles; Calcium; Female; Humans; Large-Conductance Calcium-Activate | 2012 |
Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels.
Topics: Animals; Benzimidazoles; Carboxylic Acids; Electric Stimulation; Enzyme Inhibitors; Large-Conductanc | 2013 |
Enhancement of contraction of rat mesenteric artery by acteoside: role of endothelial nitric oxide.
Topics: Acetylcholine; Animals; Benzimidazoles; Dose-Response Relationship, Drug; Endothelium, Vascular; Enz | 2002 |
[BK channels play an important role as a negative feedback mechanism in the regulation of spontaneous rhythmic contraction of urinary bladder smooth muscles].
Topics: Action Potentials; Animals; Benzimidazoles; Feedback, Physiological; Guinea Pigs; In Vitro Technique | 2002 |
Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle.
Topics: Animals; Benzimidazoles; Calcium Channel Agonists; Calcium Channels; Charybdotoxin; Electrophysiolog | 1994 |
NS 1619 activates Ca2+-activated K+ currents in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Animals; Benzimidazoles; Calcium; Charybdotoxin; Electric Stimulation; Ep | 1997 |
Melatonin directly constricts rat cerebral arteries through modulation of potassium channels.
Topics: Animals; Apamin; Benzimidazoles; Cerebral Arteries; Charybdotoxin; GTP-Binding Proteins; Ketanserin; | 1997 |
Inhibitory effects of large Ca2+-activated K+ channel blockers on beta-adrenergic- and NO-donor-mediated relaxations of human and guinea-pig airway smooth muscles.
Topics: Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Albuterol; Animals; Benzimidazoles; Bronch | 1998 |
Inhibition of cholinergic neurotransmission in guinea pig trachea by NS1619, a putative activator of large-conductance, calcium-activated potassium channels.
Topics: Acetylcholine; Animals; Benzimidazoles; Calcium; Cholinergic Agonists; Depression, Chemical; Dogs; E | 1998 |
Differential effects of pinacidil, cromakalim, and NS 1619 on electrically evoked contractions in rat vas deferens.
Topics: Animals; Benzimidazoles; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; In Vitro Techni | 1997 |
Effects of melatonin on rat pial arteriolar diameter in vivo.
Topics: Algorithms; Animals; Antioxidants; Arterioles; Benzimidazoles; Dose-Response Relationship, Drug; Enz | 1999 |
Cerebral artery K(ATP)- and K(Ca)-channel activity and contractility: changes with development.
Topics: 4-Aminopyridine; Animals; Benzimidazoles; Calcium; Fetus; In Vitro Techniques; Middle Cerebral Arter | 2000 |
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Apamin; Barium; Benzimidazoles; Calcium Channel Bl | 2001 |
Potassium channels and human corporeal smooth muscle cell tone: further evidence of the physiological relevance of the Maxi-K channel subtype to the regulation of human corporeal smooth muscle tone in vitro.
Topics: Benzimidazoles; Cells, Cultured; Charybdotoxin; Electrophysiology; Erectile Dysfunction; Humans; In | 2002 |