ns 1619 has been researched along with Hypoxia in 8 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if doxapram stimulates the carotid body through the same mechanism as hypoxia, we compared the effects of doxapram and hypoxia on isolated-perfused carotid bodies in rabbits." | 3.73 | Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction. ( Kikuchi, K; Nakano, H; Ohsaki, Y; Osanai, S; Takahashi, T, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, R | 1 |
| Hu, XQ | 1 |
| Xiao, D | 1 |
| Yang, S | 1 |
| Wilson, SM | 1 |
| Longo, LD | 1 |
| Zhang, L | 1 |
| McCullough, DJ | 1 |
| Vang, A | 1 |
| Choudhary, G | 1 |
| Borchert, GH | 1 |
| Yang, C | 1 |
| Kolár, F | 1 |
| Takahashi, T | 2 |
| Osanai, S | 2 |
| Nakano, H | 2 |
| Ohsaki, Y | 2 |
| Kikuchi, K | 2 |
| Shi, Y | 1 |
| Jiang, MT | 1 |
| Su, J | 1 |
| Hutchins, W | 1 |
| Konorev, E | 1 |
| Baker, JE | 1 |
| Armstead, WM | 2 |
8 other studies available for ns 1619 and Hypoxia
| Article | Year |
|---|---|
Chronic hypoxia inhibits pregnancy-induced upregulation of SKCa channel expression and function in uterine arteries.
Topics: Animals; Benzimidazoles; Chronic Disease; Female; Hypoxia; Indoles; Oximes; Pregnancy; Sheep; Small- | 2013 |
NS1619-induced vasodilation is enhanced and differentially mediated in chronically hypoxic lungs.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Calcium Channels, L-Type; Chronic Disease; Disease | 2014 |
Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats.
Topics: Animals; Benzimidazoles; Blotting, Western; Cell Separation; Cell Survival; Cells, Cultured; Chronic | 2011 |
Doxapram stimulates carotid body with different mechanisms from hypoxic chemotransduction.
Topics: Animals; Benzimidazoles; Carotid Body; Chemoreceptor Cells; Doxapram; Electrophysiology; Halothane; | 2003 |
Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction.
Topics: Anesthetics, Inhalation; Animals; Benzimidazoles; Carotid Body; Carotid Sinus; Cromakalim; Dose-Resp | 2005 |
Mitochondrial big conductance KCa channel and cardioprotection in infant rabbit heart.
Topics: Animals; Animals, Newborn; Benzimidazoles; Coronary Circulation; Heart; Heart Rate; Hypoxia; Indoles | 2007 |
Role of activation of calcium-sensitive K+ channels in NO- and hypoxia-induced pial artery vasodilation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Contribution of kca channel activation to hypoxic cerebrovasodilation does not involve NO.
Topics: Animals; Arteries; Benzimidazoles; Cerebrovascular Circulation; Cyclic GMP; Endorphins; Enzyme Inhib | 1998 |