ns 1619 has been researched along with Glioma in 6 studies
NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " For example, Temozolomide (TMZ) exhibits some antitumor activity against brain tumors, so does Trastuzumab (Herceptin, Her-2 inhibitor), which might be effective against Her2 neu overexpressing gliomas." | 3.75 | Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model. ( Khaitan, D; Meister, EA; Ningaraj, NS; Sankpal, UT; Vats, TS, 2009) |
| "The phloretin-induced increase in intracellular Ca(2+) was unaffected by the removal of extracellular Ca(2+) and co-application of paxilline." | 1.32 | BK channel openers inhibit migration of human glioma cells. ( Basrai, D; Bolz, J; Jung, S; Kraft, R; Krause, P; Liebmann, L; Patt, S, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, RP | 1 |
| Xue, YX | 3 |
| Huang, J | 1 |
| Wang, JH | 3 |
| Zhao, SY | 1 |
| Guan, TT | 1 |
| Zhang, Z | 1 |
| Gu, YT | 3 |
| Ningaraj, NS | 1 |
| Sankpal, UT | 1 |
| Khaitan, D | 1 |
| Meister, EA | 1 |
| Vats, TS | 1 |
| Wei, XY | 1 |
| Zhang, H | 1 |
| Li, Y | 1 |
| Wang, YF | 1 |
| ShangGuan, QR | 1 |
| Zhang, JX | 1 |
| Qin, LJ | 1 |
| Kraft, R | 1 |
| Krause, P | 1 |
| Jung, S | 1 |
| Basrai, D | 1 |
| Liebmann, L | 1 |
| Bolz, J | 1 |
| Patt, S | 1 |
| Debska, G | 1 |
| Kicinska, A | 1 |
| Dobrucki, J | 1 |
| Dworakowska, B | 1 |
| Nurowska, E | 1 |
| Skalska, J | 1 |
| Dolowy, K | 1 |
| Szewczyk, A | 1 |
6 other studies available for ns 1619 and Glioma
| Article | Year |
|---|---|
NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Brain Neoplasms; Carotid Arteries; Caveolin 1; Cell | 2016 |
Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineopl | 2009 |
Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Cell Membrane Permeability; Disease M | 2011 |
Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Claudin-5; En | 2012 |
BK channel openers inhibit migration of human glioma cells.
Topics: Benzimidazoles; Cell Line, Tumor; Cell Migration Inhibition; Cell Movement; Glioma; Humans; Large-Co | 2003 |
Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
Topics: Benzimidazoles; Charybdotoxin; Chlorophenols; Glioma; Humans; Membrane Potentials; Mitochondria; Pat | 2003 |