Page last updated: 2024-11-01

ns 1619 and Glioma

ns 1619 has been researched along with Glioma in 6 studies

NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" For example, Temozolomide (TMZ) exhibits some antitumor activity against brain tumors, so does Trastuzumab (Herceptin, Her-2 inhibitor), which might be effective against Her2 neu overexpressing gliomas."3.75Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model. ( Khaitan, D; Meister, EA; Ningaraj, NS; Sankpal, UT; Vats, TS, 2009)
"The phloretin-induced increase in intracellular Ca(2+) was unaffected by the removal of extracellular Ca(2+) and co-application of paxilline."1.32BK channel openers inhibit migration of human glioma cells. ( Basrai, D; Bolz, J; Jung, S; Kraft, R; Krause, P; Liebmann, L; Patt, S, 2003)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cai, RP1
Xue, YX3
Huang, J1
Wang, JH3
Zhao, SY1
Guan, TT1
Zhang, Z1
Gu, YT3
Ningaraj, NS1
Sankpal, UT1
Khaitan, D1
Meister, EA1
Vats, TS1
Wei, XY1
Zhang, H1
Li, Y1
Wang, YF1
ShangGuan, QR1
Zhang, JX1
Qin, LJ1
Kraft, R1
Krause, P1
Jung, S1
Basrai, D1
Liebmann, L1
Bolz, J1
Patt, S1
Debska, G1
Kicinska, A1
Dobrucki, J1
Dworakowska, B1
Nurowska, E1
Skalska, J1
Dolowy, K1
Szewczyk, A1

Other Studies

6 other studies available for ns 1619 and Glioma

ArticleYear
NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells.
    Journal of the neurological sciences, 2016, Oct-15, Volume: 369

    Topics: Animals; Antineoplastic Agents; Benzimidazoles; Brain Neoplasms; Carotid Arteries; Caveolin 1; Cell

2016
Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model.
    Cancer biology & therapy, 2009, Volume: 8, Issue:20

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineopl

2009
Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats.
    Neuroscience letters, 2011, Apr-15, Volume: 493, Issue:3

    Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Cell Membrane Permeability; Disease M

2011
Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.
    Journal of molecular neuroscience : MN, 2012, Volume: 48, Issue:1

    Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Claudin-5; En

2012
BK channel openers inhibit migration of human glioma cells.
    Pflugers Archiv : European journal of physiology, 2003, Volume: 446, Issue:2

    Topics: Benzimidazoles; Cell Line, Tumor; Cell Migration Inhibition; Cell Movement; Glioma; Humans; Large-Co

2003
Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
    Biochemical pharmacology, 2003, Jun-01, Volume: 65, Issue:11

    Topics: Benzimidazoles; Charybdotoxin; Chlorophenols; Glioma; Humans; Membrane Potentials; Mitochondria; Pat

2003